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A prospective follow-up of two 21/7 cycles followed by two extended regimen 84/7 cycles with contraceptive pills containing ethinyl estradiol and drospirenone.
Isr Med Assoc J. 2010 Jul; 12(7):400-5.IM

Abstract

BACKGROUND

Continuous use of combined oral contraceptives is currently attracting growing interest as a means of improving menstrual related symptoms and reducing the number of bleeding days.

OBJECTIVES

To evaluate bleeding patterns, menstrual symptoms and quality of life with an extended 84/7 oral contraceptive regimen versus 21/7 cycles.

METHODS

In two consecutive run-in cycles, 30 microg ethinyl estradiol and 3 mg drospirenone tablets taken on days 1-21 were followed by a tablet-free period from days 22 to 28 of each cycle and then by two 84 day cycles of pill use with a 7 day tablet-free interval. The primary outcome was the total number of bleeding/spotting days. Secondary outcomes were severity of daily symptoms, general well-being determined by the PGWBI questionnaire, and overall treatment satisfaction.

RESULTS

Of the 137 women invited to participate in the study 109 (aged 18-40 years) were enrolled. The number of bleeding days decreased by about one-third from a calculated 31.8 days of bleeding under a cyclic 21/7 regimen to an expected total of 21.8 days for the extended 84/7 regimen. The incidence of menorrhagia, intermenstrual bleeding, dysmenorrhea, abdominal bloating, breast tenderness, depressive moods and irritability - when compared at enrollment and at the end of the second extended study period--was significantly lower (P < 0.005) among women on the continuous pill regimen. The median (range) global PGWBI scores were not substantially different before and after the extended use cycles: 78.2 (39.1-96.4) and 77.3 (30.9-96.4), respectively. Body weight and skin condition also remained constant. At the completion of the study: 65.5% of the women were either highly satisfied (41.4%) or satisfied (24.1%) with the extended regimen.

CONCLUSIONS

The extended 84/7 regimen was found to be satisfactory for the majority of participants and was associated with a decrease in the number of bleeding days and an improvement in menstrual symptoms compared to 21/7 cycles.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer, Israel. dseidman@tau.ac.ilNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20862819

Citation

Seidman, Daniel S., et al. "A Prospective Follow-up of Two 21/7 Cycles Followed By Two Extended Regimen 84/7 Cycles With Contraceptive Pills Containing Ethinyl Estradiol and Drospirenone." The Israel Medical Association Journal : IMAJ, vol. 12, no. 7, 2010, pp. 400-5.
Seidman DS, Yeshaya A, Ber A, et al. A prospective follow-up of two 21/7 cycles followed by two extended regimen 84/7 cycles with contraceptive pills containing ethinyl estradiol and drospirenone. Isr Med Assoc J. 2010;12(7):400-5.
Seidman, D. S., Yeshaya, A., Ber, A., Amodai, I., Feinstein, I., Finkel, I., Gordon, N., Porat, N., Samuel, D., Shiran-Makler, E., & Wolman, I. (2010). A prospective follow-up of two 21/7 cycles followed by two extended regimen 84/7 cycles with contraceptive pills containing ethinyl estradiol and drospirenone. The Israel Medical Association Journal : IMAJ, 12(7), 400-5.
Seidman DS, et al. A Prospective Follow-up of Two 21/7 Cycles Followed By Two Extended Regimen 84/7 Cycles With Contraceptive Pills Containing Ethinyl Estradiol and Drospirenone. Isr Med Assoc J. 2010;12(7):400-5. PubMed PMID: 20862819.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A prospective follow-up of two 21/7 cycles followed by two extended regimen 84/7 cycles with contraceptive pills containing ethinyl estradiol and drospirenone. AU - Seidman,Daniel S, AU - Yeshaya,Arie, AU - Ber,Amos, AU - Amodai,Ida, AU - Feinstein,Itzhak, AU - Finkel,Israelit, AU - Gordon,Nina, AU - Porat,Noga, AU - Samuel,Dganit, AU - Shiran-Makler,Einat, AU - Wolman,Igal, PY - 2010/9/25/entrez PY - 2010/9/25/pubmed PY - 2010/10/22/medline SP - 400 EP - 5 JF - The Israel Medical Association journal : IMAJ JO - Isr. Med. Assoc. J. VL - 12 IS - 7 N2 - BACKGROUND: Continuous use of combined oral contraceptives is currently attracting growing interest as a means of improving menstrual related symptoms and reducing the number of bleeding days. OBJECTIVES: To evaluate bleeding patterns, menstrual symptoms and quality of life with an extended 84/7 oral contraceptive regimen versus 21/7 cycles. METHODS: In two consecutive run-in cycles, 30 microg ethinyl estradiol and 3 mg drospirenone tablets taken on days 1-21 were followed by a tablet-free period from days 22 to 28 of each cycle and then by two 84 day cycles of pill use with a 7 day tablet-free interval. The primary outcome was the total number of bleeding/spotting days. Secondary outcomes were severity of daily symptoms, general well-being determined by the PGWBI questionnaire, and overall treatment satisfaction. RESULTS: Of the 137 women invited to participate in the study 109 (aged 18-40 years) were enrolled. The number of bleeding days decreased by about one-third from a calculated 31.8 days of bleeding under a cyclic 21/7 regimen to an expected total of 21.8 days for the extended 84/7 regimen. The incidence of menorrhagia, intermenstrual bleeding, dysmenorrhea, abdominal bloating, breast tenderness, depressive moods and irritability - when compared at enrollment and at the end of the second extended study period--was significantly lower (P < 0.005) among women on the continuous pill regimen. The median (range) global PGWBI scores were not substantially different before and after the extended use cycles: 78.2 (39.1-96.4) and 77.3 (30.9-96.4), respectively. Body weight and skin condition also remained constant. At the completion of the study: 65.5% of the women were either highly satisfied (41.4%) or satisfied (24.1%) with the extended regimen. CONCLUSIONS: The extended 84/7 regimen was found to be satisfactory for the majority of participants and was associated with a decrease in the number of bleeding days and an improvement in menstrual symptoms compared to 21/7 cycles. SN - 1565-1088 UR - https://www.unboundmedicine.com/medline/citation/20862819/A_prospective_follow_up_of_two_21/7_cycles_followed_by_two_extended_regimen_84/7_cycles_with_contraceptive_pills_containing_ethinyl_estradiol_and_drospirenone_ L2 - http://www.ima.org.il/IMAJ/ViewArticle.aspx?year=2010&amp;month=07&amp;page=400 DB - PRIME DP - Unbound Medicine ER -