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[Simultaneous determination of chlorogenic acid, cryptochlorogenic acid, caffeic acid, naringin, hesperidin and linarin in xiao'erjinning oral liquid by an HPLC method].
Zhongguo Zhong Yao Za Zhi. 2010 Jul; 35(13):1702-5.ZZ

Abstract

OBJECTIVE

To develop a HPLC method for the simultaneous determination of chlorogenic acid, cryptochlorogenic acid, caffeic acid, naringin, hesperidin and linarin in xiao' erjinning oral liquid.

METHOD

The chromatographic separation was achieved on a Lichrospher C18 (4.6 mm x 250 mm, 5 microm) column with a mobile phase which was composed of acetonitrile(A) and 0.4% phosphoric acid(B) for gradient elution (10:90-18:82-27:73). The flow rate was (0.8-1.1-0.8) mL x min(-1), the column temperature was 30 degrees C and the detection wavelength was set at 300 nm.

RESULT

The results showed that 6 effective components were separated well and showed good linearity. The average recoveries were between 95%-105%.

CONCLUSION

The method is proved to be rapid, accurate, credible and repeatable. It can be used for the quality control of Xiao'erjinning oral liquid.

Authors+Show Affiliations

Wang J
Nanjing University of Chinese Medicine, Nanjing 210029, China.
Zhang X
No affiliation info available
Wu X
No affiliation info available
Zhao X
No affiliation info available
Di L
No affiliation info available
Guo Q
No affiliation info available
Wang S
No affiliation info available

MeSH

Caffeic AcidsChlorogenic AcidChromatography, High Pressure LiquidDosage FormsDrugs, Chinese HerbalFlavanonesGlycosidesHesperidin

Pub Type(s)

Evaluation Study
Journal Article

Language

chi

PubMed ID

20862961

Citation

Wang, Jing, et al. "[Simultaneous Determination of Chlorogenic Acid, Cryptochlorogenic Acid, Caffeic Acid, Naringin, Hesperidin and Linarin in Xiao'erjinning Oral Liquid By an HPLC Method]." Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, vol. 35, no. 13, 2010, pp. 1702-5.
Wang J, Zhang X, Wu X, et al. [Simultaneous determination of chlorogenic acid, cryptochlorogenic acid, caffeic acid, naringin, hesperidin and linarin in xiao'erjinning oral liquid by an HPLC method]. Zhongguo Zhong Yao Za Zhi. 2010;35(13):1702-5.
Wang, J., Zhang, X., Wu, X., Zhao, X., Di, L., Guo, Q., & Wang, S. (2010). [Simultaneous determination of chlorogenic acid, cryptochlorogenic acid, caffeic acid, naringin, hesperidin and linarin in xiao'erjinning oral liquid by an HPLC method]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, 35(13), 1702-5.
Wang J, et al. [Simultaneous Determination of Chlorogenic Acid, Cryptochlorogenic Acid, Caffeic Acid, Naringin, Hesperidin and Linarin in Xiao'erjinning Oral Liquid By an HPLC Method]. Zhongguo Zhong Yao Za Zhi. 2010;35(13):1702-5. PubMed PMID: 20862961.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Simultaneous determination of chlorogenic acid, cryptochlorogenic acid, caffeic acid, naringin, hesperidin and linarin in xiao'erjinning oral liquid by an HPLC method]. AU - Wang,Jing, AU - Zhang,Xinzhuang, AU - Wu,Xiaoyan, AU - Zhao,Xiaoli, AU - Di,Liuqing, AU - Guo,Qing, AU - Wang,Shouchuan, PY - 2010/9/25/entrez PY - 2010/9/25/pubmed PY - 2010/10/22/medline SP - 1702 EP - 5 JF - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica JO - Zhongguo Zhong Yao Za Zhi VL - 35 IS - 13 N2 - OBJECTIVE: To develop a HPLC method for the simultaneous determination of chlorogenic acid, cryptochlorogenic acid, caffeic acid, naringin, hesperidin and linarin in xiao' erjinning oral liquid. METHOD: The chromatographic separation was achieved on a Lichrospher C18 (4.6 mm x 250 mm, 5 microm) column with a mobile phase which was composed of acetonitrile(A) and 0.4% phosphoric acid(B) for gradient elution (10:90-18:82-27:73). The flow rate was (0.8-1.1-0.8) mL x min(-1), the column temperature was 30 degrees C and the detection wavelength was set at 300 nm. RESULT: The results showed that 6 effective components were separated well and showed good linearity. The average recoveries were between 95%-105%. CONCLUSION: The method is proved to be rapid, accurate, credible and repeatable. It can be used for the quality control of Xiao'erjinning oral liquid. SN - 1001-5302 UR - https://www.unboundmedicine.com/medline/citation/20862961/[Simultaneous_determination_of_chlorogenic_acid_cryptochlorogenic_acid_caffeic_acid_naringin_hesperidin_and_linarin_in_xiao'erjinning_oral_liquid_by_an_HPLC_method]_ DB - PRIME DP - Unbound Medicine ER -