Asymmetric allylic alkylation in combination with ring-closing metathesis for the preparation of chiral N-heterocycles.Org Lett. 2010 Oct 15; 12(20):4658-60.OL
Abstract
Asymmetric copper-catalyzed allylic substitution with methylmagnesium bromide is employed in combination with ring-closing olefin metathesis or ene-yne metathesis to achieve the synthesis of chiral, unsaturated nitrogen heterocycles. The resulting six- to eight-membered chiral heterocycles are accessible in high yields and with excellent enantioselectivities.
Links
Pub Type(s)
Journal Article
Language
eng
PubMed ID
20863080
Citation
Teichert, Johannes F., et al. "Asymmetric Allylic Alkylation in Combination With Ring-closing Metathesis for the Preparation of Chiral N-heterocycles." Organic Letters, vol. 12, no. 20, 2010, pp. 4658-60.
Teichert JF, Zhang S, van Zijl AW, et al. Asymmetric allylic alkylation in combination with ring-closing metathesis for the preparation of chiral N-heterocycles. Org Lett. 2010;12(20):4658-60.
Teichert, J. F., Zhang, S., van Zijl, A. W., Slaa, J. W., Minnaard, A. J., & Feringa, B. L. (2010). Asymmetric allylic alkylation in combination with ring-closing metathesis for the preparation of chiral N-heterocycles. Organic Letters, 12(20), 4658-60. https://doi.org/10.1021/ol101944j
Teichert JF, et al. Asymmetric Allylic Alkylation in Combination With Ring-closing Metathesis for the Preparation of Chiral N-heterocycles. Org Lett. 2010 Oct 15;12(20):4658-60. PubMed PMID: 20863080.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Asymmetric allylic alkylation in combination with ring-closing metathesis for the preparation of chiral N-heterocycles.
AU - Teichert,Johannes F,
AU - Zhang,Suyan,
AU - van Zijl,Anthoni W,
AU - Slaa,Jan Willem,
AU - Minnaard,Adriaan J,
AU - Feringa,Ben L,
PY - 2010/9/25/entrez
PY - 2010/9/25/pubmed
PY - 2011/1/22/medline
SP - 4658
EP - 60
JF - Organic letters
JO - Org Lett
VL - 12
IS - 20
N2 - Asymmetric copper-catalyzed allylic substitution with methylmagnesium bromide is employed in combination with ring-closing olefin metathesis or ene-yne metathesis to achieve the synthesis of chiral, unsaturated nitrogen heterocycles. The resulting six- to eight-membered chiral heterocycles are accessible in high yields and with excellent enantioselectivities.
SN - 1523-7052
UR - https://www.unboundmedicine.com/medline/citation/20863080/Asymmetric_allylic_alkylation_in_combination_with_ring_closing_metathesis_for_the_preparation_of_chiral_N_heterocycles_
L2 - https://doi.org/10.1021/ol101944j
DB - PRIME
DP - Unbound Medicine
ER -
