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Serum uric acid levels predict incident nonalcoholic fatty liver disease in healthy Korean men.
Metabolism. 2011 Jun; 60(6):860-6.M

Abstract

The objective of the study was to assess the prospective association between serum uric acid levels and incident nonalcoholic fatty liver disease in a cohort of healthy Korean men. A cohort study was performed on 5741 Korean men, 30 to 59 years of age, with no evidence of fatty liver disease on liver ultrasound and with no major risk factors for liver disease at baseline. Study participants were followed in annual or biennial health examinations between 2002 and 2008. The presence of fatty liver was determined at each examination by ultrasound. Cox proportional hazards models were used to evaluate the association of baseline and time-dependent levels of serum uric acid with incident fatty liver, adjusted for potential confounders. During 23,995 person-years of follow-up, 1717 participants developed fatty liver on ultrasound examination. After adjustment for age, body mass index, smoking, and alcohol intake, the hazard ratios (95% confidence intervals) for incident fatty liver comparing quartiles 2 to 4 of serum uric acid to quartile 1 were 1.17 (1.01-1.37), 1.28 (1.11-1.48), and 1.51 (1.31-1.73), respectively (P for trend = .001). The adjusted hazard ratio comparing participants with hyperuricemia (serum uric acid ≥7.0 mg/dL) to those with normouricemia (<7.0 mg/dL) was 1.29 (1.14-1.46). A graded and statistically significant association persisted after adjusting for other cardiometabolic factors and also in time-dependent models. Serum uric acid was an independent risk factor of incident fatty liver detected by ultrasonography. Additional research should clarify the mechanisms underlying this association and the role of hyperuricemia in the development of fatty liver.

Authors+Show Affiliations

Department of Occupational Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul 110-746, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20863537

Citation

Ryu, Seungho, et al. "Serum Uric Acid Levels Predict Incident Nonalcoholic Fatty Liver Disease in Healthy Korean Men." Metabolism: Clinical and Experimental, vol. 60, no. 6, 2011, pp. 860-6.
Ryu S, Chang Y, Kim SG, et al. Serum uric acid levels predict incident nonalcoholic fatty liver disease in healthy Korean men. Metabolism. 2011;60(6):860-6.
Ryu, S., Chang, Y., Kim, S. G., Cho, J., & Guallar, E. (2011). Serum uric acid levels predict incident nonalcoholic fatty liver disease in healthy Korean men. Metabolism: Clinical and Experimental, 60(6), 860-6. https://doi.org/10.1016/j.metabol.2010.08.005
Ryu S, et al. Serum Uric Acid Levels Predict Incident Nonalcoholic Fatty Liver Disease in Healthy Korean Men. Metabolism. 2011;60(6):860-6. PubMed PMID: 20863537.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum uric acid levels predict incident nonalcoholic fatty liver disease in healthy Korean men. AU - Ryu,Seungho, AU - Chang,Yoosoo, AU - Kim,Soo-Geun, AU - Cho,Juhee, AU - Guallar,Eliseo, Y1 - 2010/09/21/ PY - 2010/06/21/received PY - 2010/08/18/revised PY - 2010/08/18/accepted PY - 2010/9/25/entrez PY - 2010/9/25/pubmed PY - 2011/7/20/medline SP - 860 EP - 6 JF - Metabolism: clinical and experimental JO - Metabolism VL - 60 IS - 6 N2 - The objective of the study was to assess the prospective association between serum uric acid levels and incident nonalcoholic fatty liver disease in a cohort of healthy Korean men. A cohort study was performed on 5741 Korean men, 30 to 59 years of age, with no evidence of fatty liver disease on liver ultrasound and with no major risk factors for liver disease at baseline. Study participants were followed in annual or biennial health examinations between 2002 and 2008. The presence of fatty liver was determined at each examination by ultrasound. Cox proportional hazards models were used to evaluate the association of baseline and time-dependent levels of serum uric acid with incident fatty liver, adjusted for potential confounders. During 23,995 person-years of follow-up, 1717 participants developed fatty liver on ultrasound examination. After adjustment for age, body mass index, smoking, and alcohol intake, the hazard ratios (95% confidence intervals) for incident fatty liver comparing quartiles 2 to 4 of serum uric acid to quartile 1 were 1.17 (1.01-1.37), 1.28 (1.11-1.48), and 1.51 (1.31-1.73), respectively (P for trend = .001). The adjusted hazard ratio comparing participants with hyperuricemia (serum uric acid ≥7.0 mg/dL) to those with normouricemia (<7.0 mg/dL) was 1.29 (1.14-1.46). A graded and statistically significant association persisted after adjusting for other cardiometabolic factors and also in time-dependent models. Serum uric acid was an independent risk factor of incident fatty liver detected by ultrasonography. Additional research should clarify the mechanisms underlying this association and the role of hyperuricemia in the development of fatty liver. SN - 1532-8600 UR - https://www.unboundmedicine.com/medline/citation/20863537/Serum_uric_acid_levels_predict_incident_nonalcoholic_fatty_liver_disease_in_healthy_Korean_men_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(10)00287-8 DB - PRIME DP - Unbound Medicine ER -