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Effects of aging on muscle mechanical function and muscle fiber morphology during short-term immobilization and subsequent retraining.
J Appl Physiol (1985). 2010 Dec; 109(6):1628-34.JA

Abstract

Very little attention has been given to the combined effects of aging and disuse as separate factors causing deterioration in muscle mechanical function. Thus the purpose of this study was to investigate the effects of 2 wk of immobilization followed by 4 wk of retraining on knee extensor muscle mechanical function (e.g., maximal strength and rapid force capacity) and muscle fiber morphology in 9 old (OM: 67.3 ± 1.3 yr) and 11 young healthy men (YM: 24.4 ± 0.5 yr) with comparable levels of physical activity. Following immobilization, OM demonstrated markedly larger decreases in rapid force capacity (i.e., rate of force development, impulse) than YM (∼ 20-37 vs. ∼ 13-16%; P < 0.05). In contrast, muscle fiber area decreased in YM for type I, IIA, and IIx fibers (∼ 15-30%; P < 0.05), whereas only type IIa area decreased in OM (13.2%; P < 0.05). Subsequent retraining fully restored muscle mechanical function and muscle fiber area in YM, whereas OM showed an attenuated recovery in muscle fiber area and rapid force capacity (tendency). Changes in maximal isometric and dynamic muscle strength were similar between OM and YM. In conclusion, the present data reveal that OM may be more susceptible to the deleterious effects of short-term muscle disuse on muscle fiber size and rapid force capacity than YM. Furthermore, OM seems to require longer time to recover and regain rapid muscle force capacity, which may lead to a larger risk of falling in aged individuals after periods of short-term disuse.

Authors+Show Affiliations

Institute of Sports Medicine, Bispebjerg Hospital and Center of Healthy Aging, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark. lhvid@health.sdu.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20864557

Citation

Hvid, Lars, et al. "Effects of Aging On Muscle Mechanical Function and Muscle Fiber Morphology During Short-term Immobilization and Subsequent Retraining." Journal of Applied Physiology (Bethesda, Md. : 1985), vol. 109, no. 6, 2010, pp. 1628-34.
Hvid L, Aagaard P, Justesen L, et al. Effects of aging on muscle mechanical function and muscle fiber morphology during short-term immobilization and subsequent retraining. J Appl Physiol. 2010;109(6):1628-34.
Hvid, L., Aagaard, P., Justesen, L., Bayer, M. L., Andersen, J. L., Ørtenblad, N., Kjaer, M., & Suetta, C. (2010). Effects of aging on muscle mechanical function and muscle fiber morphology during short-term immobilization and subsequent retraining. Journal of Applied Physiology (Bethesda, Md. : 1985), 109(6), 1628-34. https://doi.org/10.1152/japplphysiol.00637.2010
Hvid L, et al. Effects of Aging On Muscle Mechanical Function and Muscle Fiber Morphology During Short-term Immobilization and Subsequent Retraining. J Appl Physiol. 2010;109(6):1628-34. PubMed PMID: 20864557.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of aging on muscle mechanical function and muscle fiber morphology during short-term immobilization and subsequent retraining. AU - Hvid,Lars, AU - Aagaard,Per, AU - Justesen,Lene, AU - Bayer,Monika L, AU - Andersen,Jesper L, AU - Ørtenblad,Niels, AU - Kjaer,Michael, AU - Suetta,Charlotte, Y1 - 2010/09/23/ PY - 2010/9/25/entrez PY - 2010/9/25/pubmed PY - 2011/3/26/medline SP - 1628 EP - 34 JF - Journal of applied physiology (Bethesda, Md. : 1985) JO - J. Appl. Physiol. VL - 109 IS - 6 N2 - Very little attention has been given to the combined effects of aging and disuse as separate factors causing deterioration in muscle mechanical function. Thus the purpose of this study was to investigate the effects of 2 wk of immobilization followed by 4 wk of retraining on knee extensor muscle mechanical function (e.g., maximal strength and rapid force capacity) and muscle fiber morphology in 9 old (OM: 67.3 ± 1.3 yr) and 11 young healthy men (YM: 24.4 ± 0.5 yr) with comparable levels of physical activity. Following immobilization, OM demonstrated markedly larger decreases in rapid force capacity (i.e., rate of force development, impulse) than YM (∼ 20-37 vs. ∼ 13-16%; P < 0.05). In contrast, muscle fiber area decreased in YM for type I, IIA, and IIx fibers (∼ 15-30%; P < 0.05), whereas only type IIa area decreased in OM (13.2%; P < 0.05). Subsequent retraining fully restored muscle mechanical function and muscle fiber area in YM, whereas OM showed an attenuated recovery in muscle fiber area and rapid force capacity (tendency). Changes in maximal isometric and dynamic muscle strength were similar between OM and YM. In conclusion, the present data reveal that OM may be more susceptible to the deleterious effects of short-term muscle disuse on muscle fiber size and rapid force capacity than YM. Furthermore, OM seems to require longer time to recover and regain rapid muscle force capacity, which may lead to a larger risk of falling in aged individuals after periods of short-term disuse. SN - 1522-1601 UR - https://www.unboundmedicine.com/medline/citation/20864557/Effects_of_aging_on_muscle_mechanical_function_and_muscle_fiber_morphology_during_short_term_immobilization_and_subsequent_retraining_ L2 - http://journals.physiology.org/doi/full/10.1152/japplphysiol.00637.2010?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -