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Morphology of partial globozoospermia.
J Androl. 2011 Mar-Apr; 32(2):199-206.JA

Abstract

Total globozoospermia is a rare sperm morphology disorder that consists of 100% round-headed, acrosomeless spermatozoa. There is also a larger group of patients whose sperm cells are partially acrosomeless. The aim of this investigation was to describe partial globozoospermia compared to total globozoospermia and normozoospermia. Ejaculates from 10 patients with more than 50% acrosomeless spermatozoa (partial globozoospermia), 3 patients with total globozoospermia, and 9 normozoospermic controls were analyzed with light microscopy, transmission electron microscopy, and flow cytometry. Qualitative and quantitative examination of spermatozoa from the 3 groups shows differences in the percentage of round-headed sperm cells and acrosome malformation. Total globozoospermia presents as a homogenous kind of teratozoospermia. Partial globozoospermia is a distinctive sperm malformation with an increased proportion of round-headed sperm cells and acrosome malformations compared to normozoospermia, which exists separately from total globozoospermia. It thereby contains oval sperm cells that may have distinctive malformations of the sperm head matrix, but also morphologically normal sperm cells that may be used in a clinical setting.

Authors+Show Affiliations

Radboud University Nijmegen Medical Centre, 791, Department of Obstetrics and Gynecology, PO Box 9101, 6500 HB Nijmegen, The Netherlands. a.dam@obgyn.umcn.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20864651

Citation

Dam, Anika H., et al. "Morphology of Partial Globozoospermia." Journal of Andrology, vol. 32, no. 2, 2011, pp. 199-206.
Dam AH, Ramos L, Dijkman HB, et al. Morphology of partial globozoospermia. J Androl. 2011;32(2):199-206.
Dam, A. H., Ramos, L., Dijkman, H. B., Woestenenk, R., Robben, H., van den Hoven, L., & Kremer, J. A. (2011). Morphology of partial globozoospermia. Journal of Andrology, 32(2), 199-206. https://doi.org/10.2164/jandrol.109.009530
Dam AH, et al. Morphology of Partial Globozoospermia. J Androl. 2011 Mar-Apr;32(2):199-206. PubMed PMID: 20864651.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Morphology of partial globozoospermia. AU - Dam,Anika H, AU - Ramos,Liliana, AU - Dijkman,Henry B, AU - Woestenenk,Rob, AU - Robben,Hannie, AU - van den Hoven,Leonie, AU - Kremer,Jan A, Y1 - 2010/09/23/ PY - 2010/9/25/entrez PY - 2010/9/25/pubmed PY - 2011/5/20/medline SP - 199 EP - 206 JF - Journal of andrology JO - J. Androl. VL - 32 IS - 2 N2 - Total globozoospermia is a rare sperm morphology disorder that consists of 100% round-headed, acrosomeless spermatozoa. There is also a larger group of patients whose sperm cells are partially acrosomeless. The aim of this investigation was to describe partial globozoospermia compared to total globozoospermia and normozoospermia. Ejaculates from 10 patients with more than 50% acrosomeless spermatozoa (partial globozoospermia), 3 patients with total globozoospermia, and 9 normozoospermic controls were analyzed with light microscopy, transmission electron microscopy, and flow cytometry. Qualitative and quantitative examination of spermatozoa from the 3 groups shows differences in the percentage of round-headed sperm cells and acrosome malformation. Total globozoospermia presents as a homogenous kind of teratozoospermia. Partial globozoospermia is a distinctive sperm malformation with an increased proportion of round-headed sperm cells and acrosome malformations compared to normozoospermia, which exists separately from total globozoospermia. It thereby contains oval sperm cells that may have distinctive malformations of the sperm head matrix, but also morphologically normal sperm cells that may be used in a clinical setting. SN - 1939-4640 UR - https://www.unboundmedicine.com/medline/citation/20864651/Morphology_of_partial_globozoospermia_ L2 - https://medlineplus.gov/maleinfertility.html DB - PRIME DP - Unbound Medicine ER -