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Palliative treatment of paraneoplastic acanthosis nigricans and oral florid papillomatosis with retinoids.
J Drugs Dermatol. 2010 Sep; 9(9):1151-3.JD

Abstract

Malignant acanthosis nigricans (MAN) with oral florid papillomatosis is a rare paraneoplastic condition affecting the skin and mucocutaneous tissues associated with an underlying malignancy. It is characterized by proliferation of keratinocytes resulting in papillomatous change and hyperpigmentation of the skin and multiple confluent warty or verrucous lesions of the oral mucous membranes. The oral involvement can interfere with the patient's ability to eat and drink. There is no specific therapy for this complication. Treatment of the underlying malignancy can lead to improvement of symptoms, but the degree of improvement varies. Here, the authors present a case of MAN with oral florid papillomatosis associated with gastric adenocarcinoma that was treated with oral retinoids resulting in significant clinical improvement of the hyperkeratosis and hyperpigmentation as well as improved patient functionality.

Authors+Show Affiliations

Swineford SL
Department of Dermatology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Drucker CR
No affiliation info available

MeSH

Acanthosis NigricansAdenocarcinomaAdultBiopsyFemaleHumansIsotretinoinKeratolytic AgentsLipPalliative CarePapillomaParaneoplastic SyndromesSkinStomach NeoplasmsTongue

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

20865850

Citation

Swineford, Sara L., and Carol R. Drucker. "Palliative Treatment of Paraneoplastic Acanthosis Nigricans and Oral Florid Papillomatosis With Retinoids." Journal of Drugs in Dermatology : JDD, vol. 9, no. 9, 2010, pp. 1151-3.
Swineford SL, Drucker CR. Palliative treatment of paraneoplastic acanthosis nigricans and oral florid papillomatosis with retinoids. J Drugs Dermatol. 2010;9(9):1151-3.
Swineford, S. L., & Drucker, C. R. (2010). Palliative treatment of paraneoplastic acanthosis nigricans and oral florid papillomatosis with retinoids. Journal of Drugs in Dermatology : JDD, 9(9), 1151-3.
Swineford SL, Drucker CR. Palliative Treatment of Paraneoplastic Acanthosis Nigricans and Oral Florid Papillomatosis With Retinoids. J Drugs Dermatol. 2010;9(9):1151-3. PubMed PMID: 20865850.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Palliative treatment of paraneoplastic acanthosis nigricans and oral florid papillomatosis with retinoids. AU - Swineford,Sara L, AU - Drucker,Carol R, PY - 2010/9/28/entrez PY - 2010/9/28/pubmed PY - 2010/10/19/medline SP - 1151 EP - 3 JF - Journal of drugs in dermatology : JDD JO - J Drugs Dermatol VL - 9 IS - 9 N2 - Malignant acanthosis nigricans (MAN) with oral florid papillomatosis is a rare paraneoplastic condition affecting the skin and mucocutaneous tissues associated with an underlying malignancy. It is characterized by proliferation of keratinocytes resulting in papillomatous change and hyperpigmentation of the skin and multiple confluent warty or verrucous lesions of the oral mucous membranes. The oral involvement can interfere with the patient's ability to eat and drink. There is no specific therapy for this complication. Treatment of the underlying malignancy can lead to improvement of symptoms, but the degree of improvement varies. Here, the authors present a case of MAN with oral florid papillomatosis associated with gastric adenocarcinoma that was treated with oral retinoids resulting in significant clinical improvement of the hyperkeratosis and hyperpigmentation as well as improved patient functionality. SN - 1545-9616 UR - https://www.unboundmedicine.com/medline/citation/20865850/Palliative_treatment_of_paraneoplastic_acanthosis_nigricans_and_oral_florid_papillomatosis_with_retinoids_ L2 - http://www.diseaseinfosearch.org/result/90 DB - PRIME DP - Unbound Medicine ER -