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Puerarin attenuates amyloid-beta-induced cognitive impairment through suppression of apoptosis in rat hippocampus in vivo.
Eur J Pharmacol 2010; 649(1-3):195-201EJ

Abstract

Elevated levels of β-amyloid (Aβ) in the brains being a hallmark of Alzheimer's disease have been believed to play a critical role in the cognitive dysfunction that occurs in Alzheimer's disease. Recent evidence suggests that Aβ induces neuronal apoptosis in the brain and in primary neuronal cultures. In this study, we investigated the effects of puerarin, a phytoestrogen isolated from Pueraria lobata, on cognitive function and neuronal apoptosis in the intrahippocampal injection of Aβ rats and its mechanism of action. The results show the intrahippocampal injection of Aβ induced a spatial memory deficit, apoptosis, and caspase-9 activation in hippocampal neurons. Puerarin treatment ameliorated Aβ(1-42)-induced cognitive impairment and reversed the increase of apoptosis in the hippocampus. The attenuation is associated with the activation of Akt and phosphorylation of Bad. These results suggest that puerarin may be an anti-Alzheimer's disease candidate drug to suppress both Alzheimer's disease-related neuronal cell apoptosis and dysfunction of the memory system.

Authors+Show Affiliations

The Institute of Medicine, Qiqihar Medical University, Qiqihar 161006, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20868658

Citation

Li, Jiaming, et al. "Puerarin Attenuates Amyloid-beta-induced Cognitive Impairment Through Suppression of Apoptosis in Rat Hippocampus in Vivo." European Journal of Pharmacology, vol. 649, no. 1-3, 2010, pp. 195-201.
Li J, Wang G, Liu J, et al. Puerarin attenuates amyloid-beta-induced cognitive impairment through suppression of apoptosis in rat hippocampus in vivo. Eur J Pharmacol. 2010;649(1-3):195-201.
Li, J., Wang, G., Liu, J., Zhou, L., Dong, M., Wang, R., ... Niu, Y. (2010). Puerarin attenuates amyloid-beta-induced cognitive impairment through suppression of apoptosis in rat hippocampus in vivo. European Journal of Pharmacology, 649(1-3), pp. 195-201. doi:10.1016/j.ejphar.2010.09.045.
Li J, et al. Puerarin Attenuates Amyloid-beta-induced Cognitive Impairment Through Suppression of Apoptosis in Rat Hippocampus in Vivo. Eur J Pharmacol. 2010 Dec 15;649(1-3):195-201. PubMed PMID: 20868658.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Puerarin attenuates amyloid-beta-induced cognitive impairment through suppression of apoptosis in rat hippocampus in vivo. AU - Li,Jiaming, AU - Wang,Gang, AU - Liu,Jicheng, AU - Zhou,Li, AU - Dong,Miaoxian, AU - Wang,Rui, AU - Li,Xueyan, AU - Li,Xiaoming, AU - Lin,Chunrong, AU - Niu,Yingcai, Y1 - 2010/09/22/ PY - 2010/04/11/received PY - 2010/07/04/revised PY - 2010/09/14/accepted PY - 2010/9/28/entrez PY - 2010/9/28/pubmed PY - 2011/3/4/medline SP - 195 EP - 201 JF - European journal of pharmacology JO - Eur. J. Pharmacol. VL - 649 IS - 1-3 N2 - Elevated levels of β-amyloid (Aβ) in the brains being a hallmark of Alzheimer's disease have been believed to play a critical role in the cognitive dysfunction that occurs in Alzheimer's disease. Recent evidence suggests that Aβ induces neuronal apoptosis in the brain and in primary neuronal cultures. In this study, we investigated the effects of puerarin, a phytoestrogen isolated from Pueraria lobata, on cognitive function and neuronal apoptosis in the intrahippocampal injection of Aβ rats and its mechanism of action. The results show the intrahippocampal injection of Aβ induced a spatial memory deficit, apoptosis, and caspase-9 activation in hippocampal neurons. Puerarin treatment ameliorated Aβ(1-42)-induced cognitive impairment and reversed the increase of apoptosis in the hippocampus. The attenuation is associated with the activation of Akt and phosphorylation of Bad. These results suggest that puerarin may be an anti-Alzheimer's disease candidate drug to suppress both Alzheimer's disease-related neuronal cell apoptosis and dysfunction of the memory system. SN - 1879-0712 UR - https://www.unboundmedicine.com/medline/citation/20868658/Puerarin_attenuates_amyloid_beta_induced_cognitive_impairment_through_suppression_of_apoptosis_in_rat_hippocampus_in_vivo_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(10)00930-1 DB - PRIME DP - Unbound Medicine ER -