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[Studies on the chemical constituents of Pachysandra terminalis and their antioxidant activity].
Zhong Yao Cai. 2010 May; 33(5):729-32.ZY

Abstract

OBJECTIVE

To study the chemical constituents from Pachysandra terminalis and their antioxidant activity.

METHODS

Chemical constituents were isolated by repeated column chromatography (silica gel, Toyopearl HW-40C and preparative HPLC). The structures of isolated compounds were elucidated on the basis of spectral data analysis. DPPH method was used to evaluate the free radical scavenging activity of the isolated compounds.

RESULTS

Six compounds were isolated and their structures were identified as follow: 2-Phenylethyl-beta-D-glucopyranoside (1), (+)Pinoresinol-4'-O-beta-D-glucopyranoside (2), Pinoresinol (3), cis-Syringin (4), 4-hydroxy-4-(3-oxo-l-butenyl)-3,5,5-trimethylcyclohex-2-en-l-one (5), 3alpha-hydroxy-5,6-epoxy-7-megastigmen-9-one (6). Compounds 2, 4, 5 showed obviously antioxidant activity, their DPPH free radical scavenging rates were 82.50%, 87.36%, and 84.56% on the concentration of 50 micromol/L, respectively.

CONCLUSION

Compounds 1-6 are isolated from this genus for the first time. Compounds 2, 4, and 5 showed significant antioxidant activities.

Authors+Show Affiliations

Li CY
School of Pharmaceutical Sciences, Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China. licy0609@126.com
Zhai HY
No affiliation info available
Tang SA
No affiliation info available
Duan HQ
No affiliation info available

MeSH

AntioxidantsBiphenyl CompoundsChromatography, High Pressure LiquidFree Radical ScavengersFuransGlucosidesGlycosidesLignansMagnetic Resonance SpectroscopyMolecular StructurePachysandraPhenylethyl AlcoholPhenylpropionatesPicratesPlant ExtractsPlants, Medicinal

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

20873557

Citation

Li, Chen-yang, et al. "[Studies On the Chemical Constituents of Pachysandra Terminalis and Their Antioxidant Activity]." Zhong Yao Cai = Zhongyaocai = Journal of Chinese Medicinal Materials, vol. 33, no. 5, 2010, pp. 729-32.
Li CY, Zhai HY, Tang SA, et al. [Studies on the chemical constituents of Pachysandra terminalis and their antioxidant activity]. Zhong Yao Cai. 2010;33(5):729-32.
Li, C. Y., Zhai, H. Y., Tang, S. A., & Duan, H. Q. (2010). [Studies on the chemical constituents of Pachysandra terminalis and their antioxidant activity]. Zhong Yao Cai = Zhongyaocai = Journal of Chinese Medicinal Materials, 33(5), 729-32.
Li CY, et al. [Studies On the Chemical Constituents of Pachysandra Terminalis and Their Antioxidant Activity]. Zhong Yao Cai. 2010;33(5):729-32. PubMed PMID: 20873557.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Studies on the chemical constituents of Pachysandra terminalis and their antioxidant activity]. AU - Li,Chen-yang, AU - Zhai,Hui-yuan, AU - Tang,Sheng-an, AU - Duan,Hong-quan, PY - 2010/9/30/entrez PY - 2010/9/30/pubmed PY - 2011/3/8/medline SP - 729 EP - 32 JF - Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials JO - Zhong Yao Cai VL - 33 IS - 5 N2 - OBJECTIVE: To study the chemical constituents from Pachysandra terminalis and their antioxidant activity. METHODS: Chemical constituents were isolated by repeated column chromatography (silica gel, Toyopearl HW-40C and preparative HPLC). The structures of isolated compounds were elucidated on the basis of spectral data analysis. DPPH method was used to evaluate the free radical scavenging activity of the isolated compounds. RESULTS: Six compounds were isolated and their structures were identified as follow: 2-Phenylethyl-beta-D-glucopyranoside (1), (+)Pinoresinol-4'-O-beta-D-glucopyranoside (2), Pinoresinol (3), cis-Syringin (4), 4-hydroxy-4-(3-oxo-l-butenyl)-3,5,5-trimethylcyclohex-2-en-l-one (5), 3alpha-hydroxy-5,6-epoxy-7-megastigmen-9-one (6). Compounds 2, 4, 5 showed obviously antioxidant activity, their DPPH free radical scavenging rates were 82.50%, 87.36%, and 84.56% on the concentration of 50 micromol/L, respectively. CONCLUSION: Compounds 1-6 are isolated from this genus for the first time. Compounds 2, 4, and 5 showed significant antioxidant activities. SN - 1001-4454 UR - https://www.unboundmedicine.com/medline/citation/20873557/[Studies_on_the_chemical_constituents_of_Pachysandra_terminalis_and_their_antioxidant_activity]_ L2 - https://medlineplus.gov/antioxidants.html DB - PRIME DP - Unbound Medicine ER -