Tags

Type your tag names separated by a space and hit enter

Prognostic value of lymph node ratio in stage III colorectal cancer.
Colorectal Dis. 2011 Oct; 13(10):1116-22.CD

Abstract

AIM

Recent reports show that a positive metastatic to examined lymph nodes ratio (LNR) has prognostic value in malignancies. This study aimed to evaluate the prognostic value of LNR in patients having resection for stage III colorectal cancer.

METHOD

From January 2000 to December 2006, patients who underwent resection for stage III colorectal carcinoma were included. All clinicopathological and follow-up data were prospectively collected. The impact of LNR and other clinicopathological factors on survival were evaluated.

RESULTS

The study included 533 (52.3% male) patients with a median age of 70 years. The median number of lymph nodes harvested and the median number of positive lymph nodes examined were 11 and 2, respectively. The median LNR was 0.263 (range, 0.03-1). After a median follow up of 52.65 months, the 5-year overall survival and disease-free survival were 55.9% and 49.4%. The patients were stratified into four groups according to LNR quartiles (1, LNR ≤ 0.125; 2, 0.125<LNR≤0.263; 3, 0.263<LNR≤0.500; 4, LNR>0.500). The 5-year overall and disease-free survival were 72.8%, 63.1%, 50.0%, 39.6% (P<0.001) and 68.5%, 54.1%, 47.2%, 29.9% (P<0.001), respectively, with increasing LNR groups. On multivariate analysis, age, T stage and LNR were independent predictors of both overall and disease-free survival. Subgroup analysis revealed that the LNR had a prognostic value for disease-free survival irrespective of number of lymph nodes harvested and location of tumour.

CONCLUSION

The LNR is an independent prognostic factor for survival in colorectal cancer and is superior to the pN category in TNM staging.

Authors+Show Affiliations

Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20874800

Citation

Wong, K P., et al. "Prognostic Value of Lymph Node Ratio in Stage III Colorectal Cancer." Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland, vol. 13, no. 10, 2011, pp. 1116-22.
Wong KP, Poon JT, Fan JK, et al. Prognostic value of lymph node ratio in stage III colorectal cancer. Colorectal Dis. 2011;13(10):1116-22.
Wong, K. P., Poon, J. T., Fan, J. K., & Law, W. L. (2011). Prognostic value of lymph node ratio in stage III colorectal cancer. Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland, 13(10), 1116-22. https://doi.org/10.1111/j.1463-1318.2010.02435.x
Wong KP, et al. Prognostic Value of Lymph Node Ratio in Stage III Colorectal Cancer. Colorectal Dis. 2011;13(10):1116-22. PubMed PMID: 20874800.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prognostic value of lymph node ratio in stage III colorectal cancer. AU - Wong,K P, AU - Poon,J T C, AU - Fan,J K M, AU - Law,W L, PY - 2010/9/30/entrez PY - 2010/9/30/pubmed PY - 2012/1/20/medline SP - 1116 EP - 22 JF - Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland JO - Colorectal Dis VL - 13 IS - 10 N2 - AIM: Recent reports show that a positive metastatic to examined lymph nodes ratio (LNR) has prognostic value in malignancies. This study aimed to evaluate the prognostic value of LNR in patients having resection for stage III colorectal cancer. METHOD: From January 2000 to December 2006, patients who underwent resection for stage III colorectal carcinoma were included. All clinicopathological and follow-up data were prospectively collected. The impact of LNR and other clinicopathological factors on survival were evaluated. RESULTS: The study included 533 (52.3% male) patients with a median age of 70 years. The median number of lymph nodes harvested and the median number of positive lymph nodes examined were 11 and 2, respectively. The median LNR was 0.263 (range, 0.03-1). After a median follow up of 52.65 months, the 5-year overall survival and disease-free survival were 55.9% and 49.4%. The patients were stratified into four groups according to LNR quartiles (1, LNR ≤ 0.125; 2, 0.125<LNR≤0.263; 3, 0.263<LNR≤0.500; 4, LNR>0.500). The 5-year overall and disease-free survival were 72.8%, 63.1%, 50.0%, 39.6% (P<0.001) and 68.5%, 54.1%, 47.2%, 29.9% (P<0.001), respectively, with increasing LNR groups. On multivariate analysis, age, T stage and LNR were independent predictors of both overall and disease-free survival. Subgroup analysis revealed that the LNR had a prognostic value for disease-free survival irrespective of number of lymph nodes harvested and location of tumour. CONCLUSION: The LNR is an independent prognostic factor for survival in colorectal cancer and is superior to the pN category in TNM staging. SN - 1463-1318 UR - https://www.unboundmedicine.com/medline/citation/20874800/Prognostic_value_of_lymph_node_ratio_in_stage_III_colorectal_cancer_ L2 - https://doi.org/10.1111/j.1463-1318.2010.02435.x DB - PRIME DP - Unbound Medicine ER -