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Human monkeypox outbreak caused by novel virus belonging to Congo Basin clade, Sudan, 2005.
Emerg Infect Dis. 2010 Oct; 16(10):1539-45.EI

Abstract

To determine the outbreak source of monkeypox virus (MPXV) infections in Unity State, Sudan, in November 2005, we conducted a retrospective investigation. MPXV was identified in a sub-Sahelian savannah environment. Three case notification categories were used: suspected, probable, and confirmed. Molecular, virologic, and serologic assays were used to test blood specimens, vesicular swabs, and crust specimens obtained from symptomatic and recovering persons. Ten laboratory-confirmed cases and 9 probable cases of MPXV were reported during September-December 2005; no deaths occurred. Human-to-human transmission up to 5 generations was described. Our investigation could not fully determine the source of the outbreak. Preliminary data indicate that the MPXV strain isolated during this outbreak was a novel virus belonging to the Congo Basin clade. Our results indicate that MPXV should be considered endemic to the wetland areas of Unity State. This finding will enhance understanding of the ecologic niche for this virus.

Authors+Show Affiliations

World Health Organization Global Alert and Response, Geneva, Switzerland. formentyp@who.intNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20875278

Citation

Formenty, Pierre, et al. "Human Monkeypox Outbreak Caused By Novel Virus Belonging to Congo Basin Clade, Sudan, 2005." Emerging Infectious Diseases, vol. 16, no. 10, 2010, pp. 1539-45.
Formenty P, Muntasir MO, Damon I, et al. Human monkeypox outbreak caused by novel virus belonging to Congo Basin clade, Sudan, 2005. Emerg Infect Dis. 2010;16(10):1539-45.
Formenty, P., Muntasir, M. O., Damon, I., Chowdhary, V., Opoka, M. L., Monimart, C., Mutasim, E. M., Manuguerra, J. C., Davidson, W. B., Karem, K. L., Cabeza, J., Wang, S., Malik, M. R., Durand, T., Khalid, A., Rioton, T., Kuong-Ruay, A., Babiker, A. A., Karsani, M. E., & Abdalla, M. S. (2010). Human monkeypox outbreak caused by novel virus belonging to Congo Basin clade, Sudan, 2005. Emerging Infectious Diseases, 16(10), 1539-45. https://doi.org/10.3201/eid1610.100713
Formenty P, et al. Human Monkeypox Outbreak Caused By Novel Virus Belonging to Congo Basin Clade, Sudan, 2005. Emerg Infect Dis. 2010;16(10):1539-45. PubMed PMID: 20875278.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Human monkeypox outbreak caused by novel virus belonging to Congo Basin clade, Sudan, 2005. AU - Formenty,Pierre, AU - Muntasir,Mohammed O, AU - Damon,Inger, AU - Chowdhary,Vipul, AU - Opoka,Martin L, AU - Monimart,Charlotte, AU - Mutasim,Elmangory M, AU - Manuguerra,Jean Claude, AU - Davidson,Whitni B, AU - Karem,Kevin L, AU - Cabeza,Jeanne, AU - Wang,Sharlenna, AU - Malik,Mamunur R, AU - Durand,Thierry, AU - Khalid,Abdalhalim, AU - Rioton,Thomas, AU - Kuong-Ruay,Andrea, AU - Babiker,Alimagboul A, AU - Karsani,Mubarak E M, AU - Abdalla,Magdi S, PY - 2010/9/30/entrez PY - 2010/9/30/pubmed PY - 2011/1/21/medline SP - 1539 EP - 45 JF - Emerging infectious diseases JO - Emerg Infect Dis VL - 16 IS - 10 N2 - To determine the outbreak source of monkeypox virus (MPXV) infections in Unity State, Sudan, in November 2005, we conducted a retrospective investigation. MPXV was identified in a sub-Sahelian savannah environment. Three case notification categories were used: suspected, probable, and confirmed. Molecular, virologic, and serologic assays were used to test blood specimens, vesicular swabs, and crust specimens obtained from symptomatic and recovering persons. Ten laboratory-confirmed cases and 9 probable cases of MPXV were reported during September-December 2005; no deaths occurred. Human-to-human transmission up to 5 generations was described. Our investigation could not fully determine the source of the outbreak. Preliminary data indicate that the MPXV strain isolated during this outbreak was a novel virus belonging to the Congo Basin clade. Our results indicate that MPXV should be considered endemic to the wetland areas of Unity State. This finding will enhance understanding of the ecologic niche for this virus. SN - 1080-6059 UR - https://www.unboundmedicine.com/medline/citation/20875278/Human_monkeypox_outbreak_caused_by_novel_virus_belonging_to_Congo_Basin_clade_Sudan_2005_ L2 - https://dx.doi.org/10.3201/eid1610.100713 DB - PRIME DP - Unbound Medicine ER -