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Adiposity hormones and dementia.
J Neurol Sci 2010; 299(1-2):30-4JN

Abstract

Adipose tissue is an endocrine and paracrine organ that contributes to both metabolic and vascular homeostasis. Overweight and obesity due to excess adipose tissue, are cornerstones of vascular risk and increase risk for late-onset dementia. Vascular risk does not exist in isolation, and is accompanied by alterations in hormonal metabolism and metabolic syndromes. Thus, while vascular risk is highlighted as a primary mechanism for elevated dementia occurrence due to obesity, hormonal risk states may also precede or result from underlying dementia-related neuropathologies and direct neuronal toxicity. This is exemplified during the prodromal phase of dementia, as vascular and metabolic parameters decline in relation to dementia development, and potentially in a way that is different from 'normal' aging. In this review will be presented a review of the epidemiology of adiposity and dementia; adipose tissue biology; and two major hormones produced by adipose tissue, leptin and adiponectin, that interact directly with the brain. In addition, a synthesis related to other lines of supporting evidence for the role of adipose hormones in dementia will be provided. Understanding the role of adipose tissue in health of the brain is pivotal to a deeper understanding of dementia processes.

Authors+Show Affiliations

Section for Psychiatry and Neurochemistry, Neuropsychiatric Epidemiology Unit at the Sahlgrenska Academy, University of Gothenburg, Sweden. deborah.gustafson@neuro.gu.se

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

20875649

Citation

Gustafson, Deborah R.. "Adiposity Hormones and Dementia." Journal of the Neurological Sciences, vol. 299, no. 1-2, 2010, pp. 30-4.
Gustafson DR. Adiposity hormones and dementia. J Neurol Sci. 2010;299(1-2):30-4.
Gustafson, D. R. (2010). Adiposity hormones and dementia. Journal of the Neurological Sciences, 299(1-2), pp. 30-4. doi:10.1016/j.jns.2010.08.036.
Gustafson DR. Adiposity Hormones and Dementia. J Neurol Sci. 2010 Dec 15;299(1-2):30-4. PubMed PMID: 20875649.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adiposity hormones and dementia. A1 - Gustafson,Deborah R, Y1 - 2010/09/27/ PY - 2010/04/30/received PY - 2010/08/19/revised PY - 2010/08/22/accepted PY - 2010/9/30/entrez PY - 2010/9/30/pubmed PY - 2011/3/17/medline SP - 30 EP - 4 JF - Journal of the neurological sciences JO - J. Neurol. Sci. VL - 299 IS - 1-2 N2 - Adipose tissue is an endocrine and paracrine organ that contributes to both metabolic and vascular homeostasis. Overweight and obesity due to excess adipose tissue, are cornerstones of vascular risk and increase risk for late-onset dementia. Vascular risk does not exist in isolation, and is accompanied by alterations in hormonal metabolism and metabolic syndromes. Thus, while vascular risk is highlighted as a primary mechanism for elevated dementia occurrence due to obesity, hormonal risk states may also precede or result from underlying dementia-related neuropathologies and direct neuronal toxicity. This is exemplified during the prodromal phase of dementia, as vascular and metabolic parameters decline in relation to dementia development, and potentially in a way that is different from 'normal' aging. In this review will be presented a review of the epidemiology of adiposity and dementia; adipose tissue biology; and two major hormones produced by adipose tissue, leptin and adiponectin, that interact directly with the brain. In addition, a synthesis related to other lines of supporting evidence for the role of adipose hormones in dementia will be provided. Understanding the role of adipose tissue in health of the brain is pivotal to a deeper understanding of dementia processes. SN - 1878-5883 UR - https://www.unboundmedicine.com/medline/citation/20875649/Adiposity_hormones_and_dementia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(10)00403-X DB - PRIME DP - Unbound Medicine ER -