TY - JOUR T1 - Impact of opium on the serum levels of TGF-β in diabetic, addicted and addicted-diabetic rats. AU - Asadikaram,Gholamreza, AU - Asiabanha,Majid, AU - Sayadi,Ahmadreza, AU - Jafarzadeh,Abdollah, AU - Hassanshahi,Gholamhossein, PY - 2010/9/30/entrez PY - 2010/9/30/pubmed PY - 2014/7/19/medline SP - 186 EP - 92 JF - Iranian journal of immunology : IJI JO - Iran J Immunol VL - 7 IS - 3 N2 - BACKGROUND: Several cells of immune system such as regulatory T cells and macrophages secrete transforming growth factor-β (TGF-β) in response to different stimuli. This cytokine has inhibitory effect on immune system and diminished production of this cytokine is associated with autoimmune disorders. OBJECTIVE: The aim of this study was to evaluate the influence of opium addiction on serum level of TGF-β in male and female diabetic and non-diabetic Wistar rats. METHODS: This experimental study was performed on normal, opium addicted, diabetic and addicted-diabetic male and female rats. Serum level of TGF-β was measured by ELISA. RESULTS: The results of our study indicated that the mean serum level of TGF-β in female addicted rats was significantly increased compared to control group (p<0.004). Conversely, in male addicted rats the mean serum level of TGF-β was lower compared with control (p<0.065). CONCLUSION: Our results suggest that opium and its derivatives have differential inductive effects on the cytokine expression in male and female rats. SN - 1735-367X UR - https://www.unboundmedicine.com/medline/citation/20876989/Impact_of_opium_on_the_serum_levels_of_TGF_β_in_diabetic_addicted_and_addicted_diabetic_rats_ L2 - https://iji.sums.ac.ir/?sid=Entrez:PubMed&amp;id=pmid:20876989&amp;key=2010.7.3.186 DB - PRIME DP - Unbound Medicine ER -