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Inhibitory effect of Thuja orientalis on TNF-α-induced vascular inflammation.
Phytother Res. 2010 Oct; 24(10):1489-95.PR

Abstract

Vascular inflammation is involved in the initiation and progression of vascular diseases including atherosclerosis. While conducting in vitro screening of 600 medicinal plant extracts, an aqueous extract of Thuja orientalis (ATO) was found to exhibit antiinflammatory activity in human umbilical vein endothelial cells (HUVEC). In the current study, the antiinflammatory activity of ATO and possible mechanisms for this were investigated in HUVEC. Preincubation with ATO (20 μg/mL) suppressed tumor necrosis factor-α (TNF-α)-induced expression of adhesion molecules including intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin at both the protein and mRNA levels. ATO also inhibited U937 monocyte adhesion to HUVEC stimulated by TNF-α. In addition, ATO attenuated TNF-α-induced p65 NF-κB translocation into the nucleus and phosphorylation of IκB-α. Furthermore, ATO significantly inhibited TNF-α-induced intracellular reactive oxygen species (ROS) production. Overall, the present data suggest that ATO can suppress TNF-α-induced vascular inflammatory processes, possibly via inhibition of ROS and NF-κB activation, in HUVEC.

Authors+Show Affiliations

Professional Graduate School of Oriental Medicine, Hanbang Body-fluid Research Center, Wonkwang University, Iksan, Chonbuk 570-749, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20878699

Citation

Lee, Yun Jung, et al. "Inhibitory Effect of Thuja Orientalis On TNF-α-induced Vascular Inflammation." Phytotherapy Research : PTR, vol. 24, no. 10, 2010, pp. 1489-95.
Lee YJ, Hwang SM, Yoon JJ, et al. Inhibitory effect of Thuja orientalis on TNF-α-induced vascular inflammation. Phytother Res. 2010;24(10):1489-95.
Lee, Y. J., Hwang, S. M., Yoon, J. J., Lee, S. M., Kyung, E. H., Kim, J. S., Kang, D. G., & Lee, H. S. (2010). Inhibitory effect of Thuja orientalis on TNF-α-induced vascular inflammation. Phytotherapy Research : PTR, 24(10), 1489-95. https://doi.org/10.1002/ptr.3131
Lee YJ, et al. Inhibitory Effect of Thuja Orientalis On TNF-α-induced Vascular Inflammation. Phytother Res. 2010;24(10):1489-95. PubMed PMID: 20878699.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibitory effect of Thuja orientalis on TNF-α-induced vascular inflammation. AU - Lee,Yun Jung, AU - Hwang,Sun Mi, AU - Yoon,Jung Joo, AU - Lee,So Min, AU - Kyung,Eun Ho, AU - Kim,Jin Sook, AU - Kang,Dae Gill, AU - Lee,Ho Sub, PY - 2010/9/30/entrez PY - 2010/9/30/pubmed PY - 2011/1/5/medline SP - 1489 EP - 95 JF - Phytotherapy research : PTR JO - Phytother Res VL - 24 IS - 10 N2 - Vascular inflammation is involved in the initiation and progression of vascular diseases including atherosclerosis. While conducting in vitro screening of 600 medicinal plant extracts, an aqueous extract of Thuja orientalis (ATO) was found to exhibit antiinflammatory activity in human umbilical vein endothelial cells (HUVEC). In the current study, the antiinflammatory activity of ATO and possible mechanisms for this were investigated in HUVEC. Preincubation with ATO (20 μg/mL) suppressed tumor necrosis factor-α (TNF-α)-induced expression of adhesion molecules including intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin at both the protein and mRNA levels. ATO also inhibited U937 monocyte adhesion to HUVEC stimulated by TNF-α. In addition, ATO attenuated TNF-α-induced p65 NF-κB translocation into the nucleus and phosphorylation of IκB-α. Furthermore, ATO significantly inhibited TNF-α-induced intracellular reactive oxygen species (ROS) production. Overall, the present data suggest that ATO can suppress TNF-α-induced vascular inflammatory processes, possibly via inhibition of ROS and NF-κB activation, in HUVEC. SN - 1099-1573 UR - https://www.unboundmedicine.com/medline/citation/20878699/Inhibitory_effect_of_Thuja_orientalis_on_TNF_α_induced_vascular_inflammation_ L2 - https://doi.org/10.1002/ptr.3131 DB - PRIME DP - Unbound Medicine ER -