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Dietary polyunsaturated fatty acids and breast cancer risk in Chinese women: a prospective cohort study.
Int J Cancer. 2011 Mar 15; 128(6):1434-41.IJ

Abstract

Breast cancer is the most common cancer in women. Controversy exists regarding the role of dietary fat in breast cancer etiology. We investigated the association of dietary polyunsaturated fatty acids (PUFAs) and the ratio of n-6 PUFAs to marine-derived n-3 PUFAs with breast cancer risk in the Shanghai Women's Health Study, a prospective cohort study including 72,571 cancer-free participants at baseline. Dietary fatty acid intake was determined using food frequency questionnaires. We used Cox proportional hazards analysis to estimate the relative risks (RRs) and 95% confidence intervals (CIs) for the association of breast cancer risk with dietary fatty acids consumption. In 583,998 person-years of follow-up, we identified 712 breast cancer cases. We found no association of breast cancer risk to dietary intake of linoleic acid, arachidonic acid, α-linolenic acid or marine-derived n-3 PUFA. We found a statistically significant interaction between n-6 PUFA intake, marine-derived n-3 PUFA intake and breast cancer risk (p = 0.008). Women with lower intake (the lowest tertile) of marine-derived n-3 PUFA and higher intake (the highest tertile) of n-6 PUFA had an increase risk for breast cancer (RR = 2.06; 95% CI = 1.27-3.34) compared to women with higher intake (the highest tertile) of marine-derived n-3 PUFAs and lower intake (the lowest tertile) of n-6 PUFAs after adjusting for potential confounders. The relative amounts of n-6 PUFA to marine-derived n-3 PUFAs may be more important for breast cancer risk than individual dietary amounts of these fatty acids.

Authors+Show Affiliations

Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203-1738, USA. harvey.j.murff@vanderbilt.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

20878979

Citation

Murff, Harvey J., et al. "Dietary Polyunsaturated Fatty Acids and Breast Cancer Risk in Chinese Women: a Prospective Cohort Study." International Journal of Cancer, vol. 128, no. 6, 2011, pp. 1434-41.
Murff HJ, Shu XO, Li H, et al. Dietary polyunsaturated fatty acids and breast cancer risk in Chinese women: a prospective cohort study. Int J Cancer. 2011;128(6):1434-41.
Murff, H. J., Shu, X. O., Li, H., Yang, G., Wu, X., Cai, H., Wen, W., Gao, Y. T., & Zheng, W. (2011). Dietary polyunsaturated fatty acids and breast cancer risk in Chinese women: a prospective cohort study. International Journal of Cancer, 128(6), 1434-41. https://doi.org/10.1002/ijc.25703
Murff HJ, et al. Dietary Polyunsaturated Fatty Acids and Breast Cancer Risk in Chinese Women: a Prospective Cohort Study. Int J Cancer. 2011 Mar 15;128(6):1434-41. PubMed PMID: 20878979.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary polyunsaturated fatty acids and breast cancer risk in Chinese women: a prospective cohort study. AU - Murff,Harvey J, AU - Shu,Xiao-Ou, AU - Li,Honglan, AU - Yang,Gong, AU - Wu,Xiauyan, AU - Cai,Hui, AU - Wen,Wanqing, AU - Gao,Yu-Tang, AU - Zheng,Wei, Y1 - 2010/11/23/ PY - 2010/05/07/received PY - 2010/09/08/accepted PY - 2010/9/30/entrez PY - 2010/9/30/pubmed PY - 2011/3/25/medline SP - 1434 EP - 41 JF - International journal of cancer JO - Int. J. Cancer VL - 128 IS - 6 N2 - Breast cancer is the most common cancer in women. Controversy exists regarding the role of dietary fat in breast cancer etiology. We investigated the association of dietary polyunsaturated fatty acids (PUFAs) and the ratio of n-6 PUFAs to marine-derived n-3 PUFAs with breast cancer risk in the Shanghai Women's Health Study, a prospective cohort study including 72,571 cancer-free participants at baseline. Dietary fatty acid intake was determined using food frequency questionnaires. We used Cox proportional hazards analysis to estimate the relative risks (RRs) and 95% confidence intervals (CIs) for the association of breast cancer risk with dietary fatty acids consumption. In 583,998 person-years of follow-up, we identified 712 breast cancer cases. We found no association of breast cancer risk to dietary intake of linoleic acid, arachidonic acid, α-linolenic acid or marine-derived n-3 PUFA. We found a statistically significant interaction between n-6 PUFA intake, marine-derived n-3 PUFA intake and breast cancer risk (p = 0.008). Women with lower intake (the lowest tertile) of marine-derived n-3 PUFA and higher intake (the highest tertile) of n-6 PUFA had an increase risk for breast cancer (RR = 2.06; 95% CI = 1.27-3.34) compared to women with higher intake (the highest tertile) of marine-derived n-3 PUFAs and lower intake (the lowest tertile) of n-6 PUFAs after adjusting for potential confounders. The relative amounts of n-6 PUFA to marine-derived n-3 PUFAs may be more important for breast cancer risk than individual dietary amounts of these fatty acids. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/20878979/Dietary_polyunsaturated_fatty_acids_and_breast_cancer_risk_in_Chinese_women:_a_prospective_cohort_study_ L2 - https://doi.org/10.1002/ijc.25703 DB - PRIME DP - Unbound Medicine ER -