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Effectiveness of tamsulosin hydrochloride and its mechanism in improving nocturia associated with lower urinary tract symptoms/benign prostatic hyperplasia.
Neurourol Urodyn. 2010 Sep; 29(7):1276-81.NU

Abstract

AIMS

To evaluate the action mechanism of α(1)-receptor blockers in improving nocturia, we have studied effectiveness of tamsulosin hydrochloride (TAM) in the patients with nocturia associated with lower urinary tract symptoms/benign prostatic hyperplasia (LUTS/BPH).

METHODS

LUTS/BPH patients with nocturia (nocturnal frequency ≥2 times per day) were administered TAM (0.2 mg/day) for 8 weeks. A frequency volume chart (FVC), the International Prostate Symptom Score (I-PSS), quality of life (QOL) index, post-void residual, and uroflowmetry were recorded before and after TAM administration for the patients. The parameters affected by TAM were examined.

RESULTS

The FVC and I-PSS of the 160 patients analyzed revealed significant clinical improvements in the nocturnal frequency. On the basis of the FVC, the patients were divided into two groups: the responder group comprising 97 patients with significantly improved nocturnal frequency and the non-responder group comprising 63 patients with less improvement in the nocturnal frequency. Significant differences between groups were observed in the following parameters: the hours of undisturbed sleep (HUS), the interval between the time of sleeping and the first instance of nocturnal voiding, the volume of urine in the first nocturnal voiding episode, nocturnal urine volume, nocturnal polyuria index, daytime urine volume, maximum and average flow rates, and post-void residual.

CONCLUSIONS

TAM improved the QOL of LUTS/BPH patients by significantly reducing the nocturnal frequency and increasing HUS; moreover, it improved nocturia by decreasing the nocturnal urine volume.

Authors+Show Affiliations

Department of Urology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. akko-maki@umin.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

20878997

Citation

Yoshida, Masaki, et al. "Effectiveness of Tamsulosin Hydrochloride and Its Mechanism in Improving Nocturia Associated With Lower Urinary Tract Symptoms/benign Prostatic Hyperplasia." Neurourology and Urodynamics, vol. 29, no. 7, 2010, pp. 1276-81.
Yoshida M, Inadome A, Masunaga K, et al. Effectiveness of tamsulosin hydrochloride and its mechanism in improving nocturia associated with lower urinary tract symptoms/benign prostatic hyperplasia. Neurourol Urodyn. 2010;29(7):1276-81.
Yoshida, M., Inadome, A., Masunaga, K., Nagata, T., & Yoshiyasu, T. (2010). Effectiveness of tamsulosin hydrochloride and its mechanism in improving nocturia associated with lower urinary tract symptoms/benign prostatic hyperplasia. Neurourology and Urodynamics, 29(7), 1276-81. https://doi.org/10.1002/nau.20872
Yoshida M, et al. Effectiveness of Tamsulosin Hydrochloride and Its Mechanism in Improving Nocturia Associated With Lower Urinary Tract Symptoms/benign Prostatic Hyperplasia. Neurourol Urodyn. 2010;29(7):1276-81. PubMed PMID: 20878997.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effectiveness of tamsulosin hydrochloride and its mechanism in improving nocturia associated with lower urinary tract symptoms/benign prostatic hyperplasia. AU - Yoshida,Masaki, AU - Inadome,Akito, AU - Masunaga,Koichi, AU - Nagata,Takashi, AU - Yoshiyasu,Takashi, PY - 2010/9/30/entrez PY - 2010/9/30/pubmed PY - 2011/1/29/medline SP - 1276 EP - 81 JF - Neurourology and urodynamics JO - Neurourol Urodyn VL - 29 IS - 7 N2 - AIMS: To evaluate the action mechanism of α(1)-receptor blockers in improving nocturia, we have studied effectiveness of tamsulosin hydrochloride (TAM) in the patients with nocturia associated with lower urinary tract symptoms/benign prostatic hyperplasia (LUTS/BPH). METHODS: LUTS/BPH patients with nocturia (nocturnal frequency ≥2 times per day) were administered TAM (0.2 mg/day) for 8 weeks. A frequency volume chart (FVC), the International Prostate Symptom Score (I-PSS), quality of life (QOL) index, post-void residual, and uroflowmetry were recorded before and after TAM administration for the patients. The parameters affected by TAM were examined. RESULTS: The FVC and I-PSS of the 160 patients analyzed revealed significant clinical improvements in the nocturnal frequency. On the basis of the FVC, the patients were divided into two groups: the responder group comprising 97 patients with significantly improved nocturnal frequency and the non-responder group comprising 63 patients with less improvement in the nocturnal frequency. Significant differences between groups were observed in the following parameters: the hours of undisturbed sleep (HUS), the interval between the time of sleeping and the first instance of nocturnal voiding, the volume of urine in the first nocturnal voiding episode, nocturnal urine volume, nocturnal polyuria index, daytime urine volume, maximum and average flow rates, and post-void residual. CONCLUSIONS: TAM improved the QOL of LUTS/BPH patients by significantly reducing the nocturnal frequency and increasing HUS; moreover, it improved nocturia by decreasing the nocturnal urine volume. SN - 1520-6777 UR - https://www.unboundmedicine.com/medline/citation/20878997/Effectiveness_of_tamsulosin_hydrochloride_and_its_mechanism_in_improving_nocturia_associated_with_lower_urinary_tract_symptoms/benign_prostatic_hyperplasia_ L2 - https://doi.org/10.1002/nau.20872 DB - PRIME DP - Unbound Medicine ER -