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65Zn incorporation in the male reproductive organs following gossypol treatment.
Acta Eur Fertil. 1990 Mar-Apr; 21(2):81-3.AE

Abstract

Male hamsters and rats were administered gossypol 10 mg/kg/day for 45 and 56 days respectively. Twenty four hours before the last dose, animals were administered 65Zn (specific activity 0.258 uci/mg) subcutaneously. A marked decrease in 65Zn incorporation was observed in testis, epididymis, seminal vesicles and prostate following drug administration. A significant increase in 65Zn uptake was however observed in vas deferens in both rat and hamster following drug administration. Our results suggest that whatever the mechanism of gossypol action on testis-epididymis complex may be, the marked decrease in 65Zn uptake by testis--epididymis complex following gossypol treatment may be related to the antispermatogenic effect of gossypol.

Authors+Show Affiliations

Department of Biophysics, Panjab University, Chandigarh, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2087942

Citation

Kalla, N R., et al. "65Zn Incorporation in the Male Reproductive Organs Following Gossypol Treatment." Acta Europaea Fertilitatis, vol. 21, no. 2, 1990, pp. 81-3.
Kalla NR, Bisnooduth U, Ranga A. 65Zn incorporation in the male reproductive organs following gossypol treatment. Acta Eur Fertil. 1990;21(2):81-3.
Kalla, N. R., Bisnooduth, U., & Ranga, A. (1990). 65Zn incorporation in the male reproductive organs following gossypol treatment. Acta Europaea Fertilitatis, 21(2), 81-3.
Kalla NR, Bisnooduth U, Ranga A. 65Zn Incorporation in the Male Reproductive Organs Following Gossypol Treatment. Acta Eur Fertil. 1990 Mar-Apr;21(2):81-3. PubMed PMID: 2087942.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 65Zn incorporation in the male reproductive organs following gossypol treatment. AU - Kalla,N R, AU - Bisnooduth,U, AU - Ranga,A, PY - 1990/3/1/pubmed PY - 1990/3/1/medline PY - 1990/3/1/entrez SP - 81 EP - 3 JF - Acta Europaea fertilitatis JO - Acta Eur. Fertil. VL - 21 IS - 2 N2 - Male hamsters and rats were administered gossypol 10 mg/kg/day for 45 and 56 days respectively. Twenty four hours before the last dose, animals were administered 65Zn (specific activity 0.258 uci/mg) subcutaneously. A marked decrease in 65Zn incorporation was observed in testis, epididymis, seminal vesicles and prostate following drug administration. A significant increase in 65Zn uptake was however observed in vas deferens in both rat and hamster following drug administration. Our results suggest that whatever the mechanism of gossypol action on testis-epididymis complex may be, the marked decrease in 65Zn uptake by testis--epididymis complex following gossypol treatment may be related to the antispermatogenic effect of gossypol. SN - 0587-2421 UR - https://www.unboundmedicine.com/medline/citation/2087942/65Zn_incorporation_in_the_male_reproductive_organs_following_gossypol_treatment_ DB - PRIME DP - Unbound Medicine ER -