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Influence of the photostabilizer in the photoprotective effects of a formulation containing UV-filters and vitamin A.
Photochem Photobiol. 2010 Nov-Dec; 86(6):1390-6.PP

Abstract

Vitamin A palmitate has been used in cosmetics; however, studies report that this substance shows photoreactivity that can lead to loss of safety and efficacy. On the other hand, photostabilizers have been used to increase sunscreen photostability and consequently their safety and effectiveness. Thus, this study aimed to evaluate the influence of photostabilizers on the photoprotective effects of a cosmetic formulation containing UV-filters and vitamin A palmitate. The formulation containing UV-filters was supplemented with vitamin A palmitate and the photostabilizers diethylhexyl 2,6-naphthalate (DEHN), bumetrizole and benzotriazolyl dodecyl p-cresol (BTDC). Hairless mice were treated daily by topical applications and irradiated (UVA/B). Erythema index, transepidermal water loss, histological/histometric analysis and number of sunburn cells (SBC) were evaluated. The results showed that all formulations protected from UV-induced enhancement of erythema and SBC but there was no difference among them. The formulation with no stabilizers reduced viable epidermis thickness due to atrophy induced by UV radiation. Thus, it can be concluded that the presence of photostabilizers influenced the effects of formulations containing UV-filters and vitamin A palmitate, which could be seen by histological and histometric analysis. Furthermore, the formulations containing the stabilizers DEHN and BTDC showed better protective effects on hairless mice skin.

Authors+Show Affiliations

Faculdade de Ciências Farmacêuticas de Ribeirão Preto-Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20880230

Citation

Benevenuto, Carolina Gomes, et al. "Influence of the Photostabilizer in the Photoprotective Effects of a Formulation Containing UV-filters and Vitamin A." Photochemistry and Photobiology, vol. 86, no. 6, 2010, pp. 1390-6.
Benevenuto CG, Di Matteo MA, Maia Campos PM, et al. Influence of the photostabilizer in the photoprotective effects of a formulation containing UV-filters and vitamin A. Photochem Photobiol. 2010;86(6):1390-6.
Benevenuto, C. G., Di Matteo, M. A., Maia Campos, P. M., & Gaspar, L. R. (2010). Influence of the photostabilizer in the photoprotective effects of a formulation containing UV-filters and vitamin A. Photochemistry and Photobiology, 86(6), 1390-6. https://doi.org/10.1111/j.1751-1097.2010.00806.x
Benevenuto CG, et al. Influence of the Photostabilizer in the Photoprotective Effects of a Formulation Containing UV-filters and Vitamin A. Photochem Photobiol. 2010 Nov-Dec;86(6):1390-6. PubMed PMID: 20880230.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of the photostabilizer in the photoprotective effects of a formulation containing UV-filters and vitamin A. AU - Benevenuto,Carolina Gomes, AU - Di Matteo,Miguel A Sala, AU - Maia Campos,Patrícia M B G, AU - Gaspar,Lorena Rigo, Y1 - 2010/09/29/ PY - 2010/10/1/entrez PY - 2010/10/1/pubmed PY - 2011/3/22/medline SP - 1390 EP - 6 JF - Photochemistry and photobiology JO - Photochem Photobiol VL - 86 IS - 6 N2 - Vitamin A palmitate has been used in cosmetics; however, studies report that this substance shows photoreactivity that can lead to loss of safety and efficacy. On the other hand, photostabilizers have been used to increase sunscreen photostability and consequently their safety and effectiveness. Thus, this study aimed to evaluate the influence of photostabilizers on the photoprotective effects of a cosmetic formulation containing UV-filters and vitamin A palmitate. The formulation containing UV-filters was supplemented with vitamin A palmitate and the photostabilizers diethylhexyl 2,6-naphthalate (DEHN), bumetrizole and benzotriazolyl dodecyl p-cresol (BTDC). Hairless mice were treated daily by topical applications and irradiated (UVA/B). Erythema index, transepidermal water loss, histological/histometric analysis and number of sunburn cells (SBC) were evaluated. The results showed that all formulations protected from UV-induced enhancement of erythema and SBC but there was no difference among them. The formulation with no stabilizers reduced viable epidermis thickness due to atrophy induced by UV radiation. Thus, it can be concluded that the presence of photostabilizers influenced the effects of formulations containing UV-filters and vitamin A palmitate, which could be seen by histological and histometric analysis. Furthermore, the formulations containing the stabilizers DEHN and BTDC showed better protective effects on hairless mice skin. SN - 1751-1097 UR - https://www.unboundmedicine.com/medline/citation/20880230/Influence_of_the_photostabilizer_in_the_photoprotective_effects_of_a_formulation_containing_UV_filters_and_vitamin_A_ L2 - https://doi.org/10.1111/j.1751-1097.2010.00806.x DB - PRIME DP - Unbound Medicine ER -