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Low-grade recurrence of a congenital high-grade supratentorial tumor with astrocytic features in the absence of adjuvant therapy.
Neuropathology. 2011 Jun; 31(3):286-91.N

Abstract

The biological behavior of pediatric gliomas and embryonal tumors can be highly variable. A few case reports have described differentiation of primitive neuroectodermal tumors (PNETs) and medulloblastomas, presumably induced by adjuvant chemotherapy and/or radiation. Herein we describe a case of a congenital supratentorial high-grade tumor with astrocytic features that, after near-total surgical resection, was not treated with adjuvant therapies. Thirteen years later the patient presented with recurrent tumor at the original surgical site. The recurrent tumor had completely different morphology compared to the original, with evidence of ganglion cell differentiation and changes more reminiscent of a low-grade pleomorphic xanthoastrocytoma. To the authors' knowledge, this is the first documented case of an untreated high-grade pediatric tumor that spontaneously differentiated into a low grade tumor. The clinical and biological implications of this are briefly discussed.

Authors+Show Affiliations

Department of Pathology, University of Kentucky, Lexington, Kentucky 40536, USA. craig.horbinski@uky.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

20880322

Citation

Horbinski, Craig, et al. "Low-grade Recurrence of a Congenital High-grade Supratentorial Tumor With Astrocytic Features in the Absence of Adjuvant Therapy." Neuropathology : Official Journal of the Japanese Society of Neuropathology, vol. 31, no. 3, 2011, pp. 286-91.
Horbinski C, Dillon D, Pittman T. Low-grade recurrence of a congenital high-grade supratentorial tumor with astrocytic features in the absence of adjuvant therapy. Neuropathology. 2011;31(3):286-91.
Horbinski, C., Dillon, D., & Pittman, T. (2011). Low-grade recurrence of a congenital high-grade supratentorial tumor with astrocytic features in the absence of adjuvant therapy. Neuropathology : Official Journal of the Japanese Society of Neuropathology, 31(3), 286-91. https://doi.org/10.1111/j.1440-1789.2010.01156.x
Horbinski C, Dillon D, Pittman T. Low-grade Recurrence of a Congenital High-grade Supratentorial Tumor With Astrocytic Features in the Absence of Adjuvant Therapy. Neuropathology. 2011;31(3):286-91. PubMed PMID: 20880322.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low-grade recurrence of a congenital high-grade supratentorial tumor with astrocytic features in the absence of adjuvant therapy. AU - Horbinski,Craig, AU - Dillon,Donita, AU - Pittman,Thomas, Y1 - 2010/09/29/ PY - 2010/10/1/entrez PY - 2010/10/1/pubmed PY - 2011/9/23/medline SP - 286 EP - 91 JF - Neuropathology : official journal of the Japanese Society of Neuropathology JO - Neuropathology VL - 31 IS - 3 N2 - The biological behavior of pediatric gliomas and embryonal tumors can be highly variable. A few case reports have described differentiation of primitive neuroectodermal tumors (PNETs) and medulloblastomas, presumably induced by adjuvant chemotherapy and/or radiation. Herein we describe a case of a congenital supratentorial high-grade tumor with astrocytic features that, after near-total surgical resection, was not treated with adjuvant therapies. Thirteen years later the patient presented with recurrent tumor at the original surgical site. The recurrent tumor had completely different morphology compared to the original, with evidence of ganglion cell differentiation and changes more reminiscent of a low-grade pleomorphic xanthoastrocytoma. To the authors' knowledge, this is the first documented case of an untreated high-grade pediatric tumor that spontaneously differentiated into a low grade tumor. The clinical and biological implications of this are briefly discussed. SN - 1440-1789 UR - https://www.unboundmedicine.com/medline/citation/20880322/Low_grade_recurrence_of_a_congenital_high_grade_supratentorial_tumor_with_astrocytic_features_in_the_absence_of_adjuvant_therapy_ L2 - https://doi.org/10.1111/j.1440-1789.2010.01156.x DB - PRIME DP - Unbound Medicine ER -