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Tissue-specific incorporation and genotoxicity of different forms of tritium in the marine mussel, Mytilus edulis.
Environ Pollut. 2011 Jan; 159(1):274-280.EP

Abstract

Marine mussels (Mytilus edulis) were exposed to seawater spiked with tritiated water (HTO) at a dose rate of 122 and 79 μGy h(-1) for 7 and 14 days, respectively, and tritiated glycine (T-Gly) at a dose rate of 4.9 μGy h(-1) over 7 days. This was followed by depuration in clean seawater for 21 days. Tissues (foot, gills, digestive gland, mantle, adductor muscle and byssus) and DNA extracts from tissues were analysed for their tritium activity concentrations. All tissues demonstrated bio-accumulation of tritium from HTO and T-Gly. Tritium from T-Gly showed increased incorporation into DNA compared to HTO. About 90% of the initial activity from HTO was depurated within one day, whereas T-Gly was depurated relatively slowly, indicating that tritium may be bound with different affinities in tissues. Both forms of tritium caused a significant induction of micronuclei in the haemocytes of mussels. Our findings identify significant differential impacts on Mytilus edulis of the two chemical forms of tritium and emphasise the need for a separate classification and control of releases of tritiated compounds, to adequately protect the marine ecosystem.

Authors+Show Affiliations

Ecotoxicology Research and Innovation Centre, School of Biomedical and Biological Sciences, University of Plymouth, Drake Circus, Plymouth PL4 8AA, UK. Electronic address: ben@ecology.su.se.Consolidated Radio-isotope Facility, University of Plymouth, Drake Circus, Plymouth PL4 8AA, UK.Ecotoxicology Research and Innovation Centre, School of Biomedical and Biological Sciences, University of Plymouth, Drake Circus, Plymouth PL4 8AA, UK.Ecotoxicology Research and Innovation Centre, School of Biomedical and Biological Sciences, University of Plymouth, Drake Circus, Plymouth PL4 8AA, UK.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20880622

Citation

Jaeschke, Benedict C., et al. "Tissue-specific Incorporation and Genotoxicity of Different Forms of Tritium in the Marine Mussel, Mytilus Edulis." Environmental Pollution (Barking, Essex : 1987), vol. 159, no. 1, 2011, pp. 274-280.
Jaeschke BC, Millward GE, Moody AJ, et al. Tissue-specific incorporation and genotoxicity of different forms of tritium in the marine mussel, Mytilus edulis. Environ Pollut. 2011;159(1):274-280.
Jaeschke, B. C., Millward, G. E., Moody, A. J., & Jha, A. N. (2011). Tissue-specific incorporation and genotoxicity of different forms of tritium in the marine mussel, Mytilus edulis. Environmental Pollution (Barking, Essex : 1987), 159(1), 274-280. https://doi.org/10.1016/j.envpol.2010.08.033
Jaeschke BC, et al. Tissue-specific Incorporation and Genotoxicity of Different Forms of Tritium in the Marine Mussel, Mytilus Edulis. Environ Pollut. 2011;159(1):274-280. PubMed PMID: 20880622.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tissue-specific incorporation and genotoxicity of different forms of tritium in the marine mussel, Mytilus edulis. AU - Jaeschke,Benedict C, AU - Millward,Geoffrey E, AU - Moody,A John, AU - Jha,Awadhesh N, Y1 - 2010/09/29/ PY - 2010/06/30/received PY - 2010/08/13/revised PY - 2010/08/20/accepted PY - 2010/10/1/entrez PY - 2010/10/1/pubmed PY - 2011/3/2/medline SP - 274 EP - 280 JF - Environmental pollution (Barking, Essex : 1987) JO - Environ Pollut VL - 159 IS - 1 N2 - Marine mussels (Mytilus edulis) were exposed to seawater spiked with tritiated water (HTO) at a dose rate of 122 and 79 μGy h(-1) for 7 and 14 days, respectively, and tritiated glycine (T-Gly) at a dose rate of 4.9 μGy h(-1) over 7 days. This was followed by depuration in clean seawater for 21 days. Tissues (foot, gills, digestive gland, mantle, adductor muscle and byssus) and DNA extracts from tissues were analysed for their tritium activity concentrations. All tissues demonstrated bio-accumulation of tritium from HTO and T-Gly. Tritium from T-Gly showed increased incorporation into DNA compared to HTO. About 90% of the initial activity from HTO was depurated within one day, whereas T-Gly was depurated relatively slowly, indicating that tritium may be bound with different affinities in tissues. Both forms of tritium caused a significant induction of micronuclei in the haemocytes of mussels. Our findings identify significant differential impacts on Mytilus edulis of the two chemical forms of tritium and emphasise the need for a separate classification and control of releases of tritiated compounds, to adequately protect the marine ecosystem. SN - 1873-6424 UR - https://www.unboundmedicine.com/medline/citation/20880622/Tissue_specific_incorporation_and_genotoxicity_of_different_forms_of_tritium_in_the_marine_mussel_Mytilus_edulis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0269-7491(10)00412-4 DB - PRIME DP - Unbound Medicine ER -
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