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Effect of phylloquinone supplementation on glucose homeostasis in humans.

Abstract

BACKGROUND

Under-γ-carboxylated osteocalcin (ucOC) increases insulin secretion and decreases glucose concentrations in mice.

OBJECTIVE

We determined whether changes in ucOC concentrations in humans were associated with changes in insulin and glucose concentrations.

DESIGN

Twenty-one community-dwelling postmenopausal women received 1 mg phylloquinone daily for 12 mo (experimental group), and 21 subjects were treated with a placebo during the same period (control group). Total serum osteocalcin, ucOC, glucose, and insulin concentrations were measured before and 6 and 12 mo after treatment. The homeostasis model assessment of insulin resistance (HOMA-IR) was calculated and correlated with ucOC concentrations.

RESULTS

Before administration of the placebo or phylloquinone, total osteocalcin, ucOC, glucose, and insulin concentrations and HOMA-IR (1.24 ± 0.15 for the control group compared with 1.93 ± 0.37 for the experimental group) did not differ. After treatment, total osteocalcin concentrations were similar at 6 and 12 mo. At 6 mo, serum ucOC concentrations in the experimental group were 0.96 ± 0.08 ng/mL compared with 2.94 ± 0.27 ng/mL in the control group (P < 0.001). At 12 mo, serum ucOC concentrations were 0.92 ± 0.09 ng/mL and 3.13 ± 0.26 ng/mL (P < 0.001) in experimental and control groups, respectively. Despite a decrease of ≈200% in ucOC concentrations, HOMA-IR was similar in the 2 groups at 6 and 12 mo (at 6 mo, HOMA-IR was 2.24 ± 0.54 and 1.52 ± 0.23 in the experimental and control groups, respectively; at 12 mo, HOMA-IR was 2.13 ± 0.38 and 1.47 ± 0.22 in the experimental and control groups, respectively; P = NS).

CONCLUSIONS

In postmenopausal women, phylloquinone administration is not associated with changes in insulin secretion and action despite reductions in ucOC concentrations. Changes in ucOC concentrations do not alter glucose metabolism in women. This trial was registered at clinicaltrials.gov as NCT00062595.

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  • Authors+Show Affiliations

    ,

    Nephrology Research Unit, Divisions of Nephrology and Hypertension and the Division of Endocrinology and Metabolism, Department of Medicine, Mayo Clinic, Rochester, MN, USA. rkumar@mayo.edu

    ,

    Source

    MeSH

    Blood Glucose
    Double-Blind Method
    Female
    Humans
    Insulin
    Insulin Resistance
    Middle Aged
    Osteocalcin
    Postmenopause
    Vitamin K 1
    Vitamins

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    20881072

    Citation

    Kumar, Rajiv, et al. "Effect of Phylloquinone Supplementation On Glucose Homeostasis in Humans." The American Journal of Clinical Nutrition, vol. 92, no. 6, 2010, pp. 1528-32.
    Kumar R, Binkley N, Vella A. Effect of phylloquinone supplementation on glucose homeostasis in humans. Am J Clin Nutr. 2010;92(6):1528-32.
    Kumar, R., Binkley, N., & Vella, A. (2010). Effect of phylloquinone supplementation on glucose homeostasis in humans. The American Journal of Clinical Nutrition, 92(6), pp. 1528-32. doi:10.3945/ajcn.2010.30108.
    Kumar R, Binkley N, Vella A. Effect of Phylloquinone Supplementation On Glucose Homeostasis in Humans. Am J Clin Nutr. 2010;92(6):1528-32. PubMed PMID: 20881072.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effect of phylloquinone supplementation on glucose homeostasis in humans. AU - Kumar,Rajiv, AU - Binkley,Neil, AU - Vella,Adrian, Y1 - 2010/09/29/ PY - 2010/10/1/entrez PY - 2010/10/1/pubmed PY - 2010/12/25/medline SP - 1528 EP - 32 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 92 IS - 6 N2 - BACKGROUND: Under-γ-carboxylated osteocalcin (ucOC) increases insulin secretion and decreases glucose concentrations in mice. OBJECTIVE: We determined whether changes in ucOC concentrations in humans were associated with changes in insulin and glucose concentrations. DESIGN: Twenty-one community-dwelling postmenopausal women received 1 mg phylloquinone daily for 12 mo (experimental group), and 21 subjects were treated with a placebo during the same period (control group). Total serum osteocalcin, ucOC, glucose, and insulin concentrations were measured before and 6 and 12 mo after treatment. The homeostasis model assessment of insulin resistance (HOMA-IR) was calculated and correlated with ucOC concentrations. RESULTS: Before administration of the placebo or phylloquinone, total osteocalcin, ucOC, glucose, and insulin concentrations and HOMA-IR (1.24 ± 0.15 for the control group compared with 1.93 ± 0.37 for the experimental group) did not differ. After treatment, total osteocalcin concentrations were similar at 6 and 12 mo. At 6 mo, serum ucOC concentrations in the experimental group were 0.96 ± 0.08 ng/mL compared with 2.94 ± 0.27 ng/mL in the control group (P < 0.001). At 12 mo, serum ucOC concentrations were 0.92 ± 0.09 ng/mL and 3.13 ± 0.26 ng/mL (P < 0.001) in experimental and control groups, respectively. Despite a decrease of ≈200% in ucOC concentrations, HOMA-IR was similar in the 2 groups at 6 and 12 mo (at 6 mo, HOMA-IR was 2.24 ± 0.54 and 1.52 ± 0.23 in the experimental and control groups, respectively; at 12 mo, HOMA-IR was 2.13 ± 0.38 and 1.47 ± 0.22 in the experimental and control groups, respectively; P = NS). CONCLUSIONS: In postmenopausal women, phylloquinone administration is not associated with changes in insulin secretion and action despite reductions in ucOC concentrations. Changes in ucOC concentrations do not alter glucose metabolism in women. This trial was registered at clinicaltrials.gov as NCT00062595. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/20881072/Effect_of_phylloquinone_supplementation_on_glucose_homeostasis_in_humans_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.2010.30108 DB - PRIME DP - Unbound Medicine ER -