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Pathogenicity of two Egyptian H5N1 highly pathogenic avian influenza viruses in domestic ducks.
Arch Virol. 2011 Jan; 156(1):37-51.AV

Abstract

Domestic ducks have been implicated in the dissemination and evolution of H5N1 highly pathogenic avian influenza (HPAI) viruses. In this study, two H5N1 HPAI viruses belonging to clade 2.2.1 isolated in Egypt in 2007 and 2008 were analyzed for their pathogenicity in domestic Pekin ducks. Both viruses produced clinical signs and mortality, but the 2008 virus was more virulent, inducing early onset of neurological signs and killing all ducks with a mean death time (MDT) of 4.1 days. The 2007 virus killed 3/8 ducks with a MDT of 7 days. Full-genome sequencing and phylogenetic analysis were used to examine differences in the virus genes that might explain the differences observed in pathogenicity. The genomes differed in 49 amino acids, with most of the differences found in the hemagglutinin protein. This increase in pathogenicity in ducks observed with certain H5N1 HPAI viruses has implications for the control of the disease, since vaccinated ducks infected with highly virulent strains shed viruses for longer periods of time, perpetuating the virus in the environment and increasing the possibility of transmission to susceptible birds.

Authors+Show Affiliations

United States Department of Agriculture, Athens, GA 30605, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

20882306

Citation

Wasilenko, J L., et al. "Pathogenicity of Two Egyptian H5N1 Highly Pathogenic Avian Influenza Viruses in Domestic Ducks." Archives of Virology, vol. 156, no. 1, 2011, pp. 37-51.
Wasilenko JL, Arafa AM, Selim AA, et al. Pathogenicity of two Egyptian H5N1 highly pathogenic avian influenza viruses in domestic ducks. Arch Virol. 2011;156(1):37-51.
Wasilenko, J. L., Arafa, A. M., Selim, A. A., Hassan, M. K., Aly, M. M., Ali, A., Nassif, S., Elebiary, E., Balish, A., Klimov, A., Suarez, D. L., Swayne, D. E., & Pantin-Jackwood, M. J. (2011). Pathogenicity of two Egyptian H5N1 highly pathogenic avian influenza viruses in domestic ducks. Archives of Virology, 156(1), 37-51. https://doi.org/10.1007/s00705-010-0813-y
Wasilenko JL, et al. Pathogenicity of Two Egyptian H5N1 Highly Pathogenic Avian Influenza Viruses in Domestic Ducks. Arch Virol. 2011;156(1):37-51. PubMed PMID: 20882306.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pathogenicity of two Egyptian H5N1 highly pathogenic avian influenza viruses in domestic ducks. AU - Wasilenko,J L, AU - Arafa,A M, AU - Selim,A A, AU - Hassan,M K, AU - Aly,M M, AU - Ali,A, AU - Nassif,S, AU - Elebiary,E, AU - Balish,A, AU - Klimov,A, AU - Suarez,D L, AU - Swayne,D E, AU - Pantin-Jackwood,M J, PY - 2010/10/1/entrez PY - 2010/10/1/pubmed PY - 2011/2/4/medline SP - 37 EP - 51 JF - Archives of virology JO - Arch Virol VL - 156 IS - 1 N2 - Domestic ducks have been implicated in the dissemination and evolution of H5N1 highly pathogenic avian influenza (HPAI) viruses. In this study, two H5N1 HPAI viruses belonging to clade 2.2.1 isolated in Egypt in 2007 and 2008 were analyzed for their pathogenicity in domestic Pekin ducks. Both viruses produced clinical signs and mortality, but the 2008 virus was more virulent, inducing early onset of neurological signs and killing all ducks with a mean death time (MDT) of 4.1 days. The 2007 virus killed 3/8 ducks with a MDT of 7 days. Full-genome sequencing and phylogenetic analysis were used to examine differences in the virus genes that might explain the differences observed in pathogenicity. The genomes differed in 49 amino acids, with most of the differences found in the hemagglutinin protein. This increase in pathogenicity in ducks observed with certain H5N1 HPAI viruses has implications for the control of the disease, since vaccinated ducks infected with highly virulent strains shed viruses for longer periods of time, perpetuating the virus in the environment and increasing the possibility of transmission to susceptible birds. SN - 1432-8798 UR - https://www.unboundmedicine.com/medline/citation/20882306/Pathogenicity_of_two_Egyptian_H5N1_highly_pathogenic_avian_influenza_viruses_in_domestic_ducks_ L2 - https://dx.doi.org/10.1007/s00705-010-0813-y DB - PRIME DP - Unbound Medicine ER -