Tags

Type your tag names separated by a space and hit enter

Liver iron status and associated haematological parameters in relation to fetal growth and pregnancy outcome in rapidly growing adolescent sheep carrying a singleton lamb derived by embryo transfer.
Reprod Fertil Dev. 2010; 22(8):1230-6.RF

Abstract

Maternal and fetal liver iron concentrations and associated haematology parameters were determined in an adolescent sheep paradigm characterised by rapid maternal growth, premature delivery and feto-placental growth restriction. Singleton-bearing dams were offered a control or high dietary intake to induce normal or growth-restricted pregnancies, respectively. Pregnancies were terminated on Day 90 or 130 of gestation or progressed to term. Relative blood volume increased (P < 0.05) and liver iron concentration decreased (P < 0.003) from mid to late gestation in control, but not in high-intake dams. At 90 and 130 days gestation, liver iron concentrations were reduced (P < 0.001) in high-intake dams but fetal liver iron was independent of dam nutrition. High intakes leading to poor pregnancy outcome at term were characterised by increased maternal haematocrit, haemoglobin, total plasma protein, albumin (all P < 0.001) and serum iron (P < 0.05), and by reduced oestradiol 17β (P < 0.001) at Day 130. Thus, high dietary intakes that promote rapid maternal growth and adiposity are associated with early depletion of maternal liver iron stores and a relative failure of normal blood volume expansion, which may, in turn, underlie the reduction in uteroplacental blood flows and fetal nutrient delivery previously established for this paradigm.

Authors+Show Affiliations

University of Aberdeen Rowett Institute of Nutrition and Health, Aberdeen, AB21 9SB, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20883648

Citation

Luther, Justin, et al. "Liver Iron Status and Associated Haematological Parameters in Relation to Fetal Growth and Pregnancy Outcome in Rapidly Growing Adolescent Sheep Carrying a Singleton Lamb Derived By Embryo Transfer." Reproduction, Fertility, and Development, vol. 22, no. 8, 2010, pp. 1230-6.
Luther J, Aitken R, Milne J, et al. Liver iron status and associated haematological parameters in relation to fetal growth and pregnancy outcome in rapidly growing adolescent sheep carrying a singleton lamb derived by embryo transfer. Reprod Fertil Dev. 2010;22(8):1230-6.
Luther, J., Aitken, R., Milne, J., McArdle, H., Gambling, L., Reynolds, L., Redmer, D., & Wallace, J. (2010). Liver iron status and associated haematological parameters in relation to fetal growth and pregnancy outcome in rapidly growing adolescent sheep carrying a singleton lamb derived by embryo transfer. Reproduction, Fertility, and Development, 22(8), 1230-6. https://doi.org/10.1071/RD10030
Luther J, et al. Liver Iron Status and Associated Haematological Parameters in Relation to Fetal Growth and Pregnancy Outcome in Rapidly Growing Adolescent Sheep Carrying a Singleton Lamb Derived By Embryo Transfer. Reprod Fertil Dev. 2010;22(8):1230-6. PubMed PMID: 20883648.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Liver iron status and associated haematological parameters in relation to fetal growth and pregnancy outcome in rapidly growing adolescent sheep carrying a singleton lamb derived by embryo transfer. AU - Luther,Justin, AU - Aitken,Raymond, AU - Milne,John, AU - McArdle,Harry, AU - Gambling,Lorraine, AU - Reynolds,Lawrence, AU - Redmer,Dale, AU - Wallace,Jacqueline, PY - 2010/02/19/received PY - 2010/06/15/accepted PY - 2010/10/2/entrez PY - 2010/10/5/pubmed PY - 2010/12/16/medline SP - 1230 EP - 6 JF - Reproduction, fertility, and development JO - Reprod. Fertil. Dev. VL - 22 IS - 8 N2 - Maternal and fetal liver iron concentrations and associated haematology parameters were determined in an adolescent sheep paradigm characterised by rapid maternal growth, premature delivery and feto-placental growth restriction. Singleton-bearing dams were offered a control or high dietary intake to induce normal or growth-restricted pregnancies, respectively. Pregnancies were terminated on Day 90 or 130 of gestation or progressed to term. Relative blood volume increased (P < 0.05) and liver iron concentration decreased (P < 0.003) from mid to late gestation in control, but not in high-intake dams. At 90 and 130 days gestation, liver iron concentrations were reduced (P < 0.001) in high-intake dams but fetal liver iron was independent of dam nutrition. High intakes leading to poor pregnancy outcome at term were characterised by increased maternal haematocrit, haemoglobin, total plasma protein, albumin (all P < 0.001) and serum iron (P < 0.05), and by reduced oestradiol 17β (P < 0.001) at Day 130. Thus, high dietary intakes that promote rapid maternal growth and adiposity are associated with early depletion of maternal liver iron stores and a relative failure of normal blood volume expansion, which may, in turn, underlie the reduction in uteroplacental blood flows and fetal nutrient delivery previously established for this paradigm. SN - 1031-3613 UR - https://www.unboundmedicine.com/medline/citation/20883648/Liver_iron_status_and_associated_haematological_parameters_in_relation_to_fetal_growth_and_pregnancy_outcome_in_rapidly_growing_adolescent_sheep_carrying_a_singleton_lamb_derived_by_embryo_transfer_ L2 - http://www.publish.csiro.au/journals/abstractHTML.cfm?J=RD&amp;V=22&amp;I=8&amp;F=RD10030abs.XML DB - PRIME DP - Unbound Medicine ER -