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Associations of sugar and artificially sweetened soda with albuminuria and kidney function decline in women.
Clin J Am Soc Nephrol. 2011 Jan; 6(1):160-6.CJ

Abstract

BACKGROUND AND OBJECTIVES

Sugar-sweetened soda is reported to be associated with increased risk for diabetes and albuminuria, but there are currently limited data on how sugar or artificially sweetened soda may be related to kidney function decline.

DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS

This study identified 3318 women participating in the Nurses' Health Study with data on soda intake and albuminuria; of these, 3256 also had data on estimated GFR (eGFR) change between 1989 and 2000. Cumulative average beverage intake was derived from the 1984, 1986, 1990, 1994, and 1998 food frequency questionnaires. Serving categories included <1/mo (referent), 1 to 4/mo, 2 to 6/wk, 1 to 1.9/d, and ≥ 2/d. Microalbuminuria (MA) was considered a urinary albumin-to-creatinine ratio of 25 to 355 μg/mg. For kidney function change, the primary outcome was a ≥ 30% decline in eGFR over 11 years; rapid eGFR decline defined as ≥ 3 ml/min per 1.73 m(2) per year was also examined.

RESULTS

Consumption of ≥ 2 servings per day of artificially sweetened (diet) soda was independently associated with eGFR decline ≥ 30% (OR 2.02, 95% CI 1.36 to 3.01) and ≥ 3 ml/min per 1.73 m(2) per year (OR 2.20, 95% CI 1.36 to 3.55). No increased risk for eGFR decline was observed for <2 servings per day of diet soda. No associations were noted between diet soda and MA or sugar soda and MA or eGFR decline.

CONCLUSIONS

Consumption of ≥ 2 servings per day of artificially sweetened soda is associated with a 2-fold increased odds for kidney function decline in women.

Authors+Show Affiliations

Channing Laboratory, Renal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. jlin11@partners.orgNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

20884773

Citation

Lin, Julie, and Gary C. Curhan. "Associations of Sugar and Artificially Sweetened Soda With Albuminuria and Kidney Function Decline in Women." Clinical Journal of the American Society of Nephrology : CJASN, vol. 6, no. 1, 2011, pp. 160-6.
Lin J, Curhan GC. Associations of sugar and artificially sweetened soda with albuminuria and kidney function decline in women. Clin J Am Soc Nephrol. 2011;6(1):160-6.
Lin, J., & Curhan, G. C. (2011). Associations of sugar and artificially sweetened soda with albuminuria and kidney function decline in women. Clinical Journal of the American Society of Nephrology : CJASN, 6(1), 160-6. https://doi.org/10.2215/CJN.03260410
Lin J, Curhan GC. Associations of Sugar and Artificially Sweetened Soda With Albuminuria and Kidney Function Decline in Women. Clin J Am Soc Nephrol. 2011;6(1):160-6. PubMed PMID: 20884773.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations of sugar and artificially sweetened soda with albuminuria and kidney function decline in women. AU - Lin,Julie, AU - Curhan,Gary C, Y1 - 2010/09/30/ PY - 2010/10/2/entrez PY - 2010/10/5/pubmed PY - 2011/5/19/medline SP - 160 EP - 6 JF - Clinical journal of the American Society of Nephrology : CJASN JO - Clin J Am Soc Nephrol VL - 6 IS - 1 N2 - BACKGROUND AND OBJECTIVES: Sugar-sweetened soda is reported to be associated with increased risk for diabetes and albuminuria, but there are currently limited data on how sugar or artificially sweetened soda may be related to kidney function decline. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This study identified 3318 women participating in the Nurses' Health Study with data on soda intake and albuminuria; of these, 3256 also had data on estimated GFR (eGFR) change between 1989 and 2000. Cumulative average beverage intake was derived from the 1984, 1986, 1990, 1994, and 1998 food frequency questionnaires. Serving categories included <1/mo (referent), 1 to 4/mo, 2 to 6/wk, 1 to 1.9/d, and ≥ 2/d. Microalbuminuria (MA) was considered a urinary albumin-to-creatinine ratio of 25 to 355 μg/mg. For kidney function change, the primary outcome was a ≥ 30% decline in eGFR over 11 years; rapid eGFR decline defined as ≥ 3 ml/min per 1.73 m(2) per year was also examined. RESULTS: Consumption of ≥ 2 servings per day of artificially sweetened (diet) soda was independently associated with eGFR decline ≥ 30% (OR 2.02, 95% CI 1.36 to 3.01) and ≥ 3 ml/min per 1.73 m(2) per year (OR 2.20, 95% CI 1.36 to 3.55). No increased risk for eGFR decline was observed for <2 servings per day of diet soda. No associations were noted between diet soda and MA or sugar soda and MA or eGFR decline. CONCLUSIONS: Consumption of ≥ 2 servings per day of artificially sweetened soda is associated with a 2-fold increased odds for kidney function decline in women. SN - 1555-905X UR - https://www.unboundmedicine.com/medline/citation/20884773/Associations_of_sugar_and_artificially_sweetened_soda_with_albuminuria_and_kidney_function_decline_in_women_ L2 - https://cjasn.asnjournals.org/cgi/pmidlookup?view=long&amp;pmid=20884773 DB - PRIME DP - Unbound Medicine ER -