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Cell transplantation for articular cartilage defects: principles of past, present, and future practice.
Cell Transplant. 2011; 20(5):593-607.CT

Abstract

As articular cartilage has very limited self-repair capability, the repair and regeneration of damaged cartilage is a major challenge. This review aims to outline the past, present, and future of cell therapies for articular cartilage defect repair. Autologous chondrocyte implantation (ACI) has been used clinically for more than 20 years, and the short, medium, and long-term clinical outcomes of three generation of ACI are extensively overviewed. Also, strategies of clinical outcome evaluation, ACI limitations, and the comparison of ACI clinical outcomes with those of other surgical techniques are discussed. Moreover, mesenchymal stem cells and pluripotent stem cells for cartilage regeneration in vitro, in vivo, and in a few clinical studies are reviewed. This review not only comprehensively analyzes the ACI clinical data but also considers the findings from state-of-the-art stem cell research on cartilage repair from bench and bedside. The conclusion provides clues for the future development of strategies for cartilage regeneration.

Authors+Show Affiliations

Center for Stem Cell and Tissue Engineering, School of Medicine, Zhejiang University, Hangzhou, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

20887665

Citation

Jiang, Yang Zi, et al. "Cell Transplantation for Articular Cartilage Defects: Principles of Past, Present, and Future Practice." Cell Transplantation, vol. 20, no. 5, 2011, pp. 593-607.
Jiang YZ, Zhang SF, Qi YY, et al. Cell transplantation for articular cartilage defects: principles of past, present, and future practice. Cell Transplant. 2011;20(5):593-607.
Jiang, Y. Z., Zhang, S. F., Qi, Y. Y., Wang, L. L., & Ouyang, H. W. (2011). Cell transplantation for articular cartilage defects: principles of past, present, and future practice. Cell Transplantation, 20(5), 593-607. https://doi.org/10.3727/096368910X532738
Jiang YZ, et al. Cell Transplantation for Articular Cartilage Defects: Principles of Past, Present, and Future Practice. Cell Transplant. 2011;20(5):593-607. PubMed PMID: 20887665.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cell transplantation for articular cartilage defects: principles of past, present, and future practice. AU - Jiang,Yang Zi, AU - Zhang,Shu Fang, AU - Qi,Yi Ying, AU - Wang,Lin Lin, AU - Ouyang,Hong Wei, Y1 - 2010/09/30/ PY - 2010/10/5/entrez PY - 2010/10/5/pubmed PY - 2012/2/10/medline SP - 593 EP - 607 JF - Cell transplantation JO - Cell Transplant VL - 20 IS - 5 N2 - As articular cartilage has very limited self-repair capability, the repair and regeneration of damaged cartilage is a major challenge. This review aims to outline the past, present, and future of cell therapies for articular cartilage defect repair. Autologous chondrocyte implantation (ACI) has been used clinically for more than 20 years, and the short, medium, and long-term clinical outcomes of three generation of ACI are extensively overviewed. Also, strategies of clinical outcome evaluation, ACI limitations, and the comparison of ACI clinical outcomes with those of other surgical techniques are discussed. Moreover, mesenchymal stem cells and pluripotent stem cells for cartilage regeneration in vitro, in vivo, and in a few clinical studies are reviewed. This review not only comprehensively analyzes the ACI clinical data but also considers the findings from state-of-the-art stem cell research on cartilage repair from bench and bedside. The conclusion provides clues for the future development of strategies for cartilage regeneration. SN - 1555-3892 UR - https://www.unboundmedicine.com/medline/citation/20887665/Cell_transplantation_for_articular_cartilage_defects:_principles_of_past_present_and_future_practice_ L2 - https://journals.sagepub.com/doi/10.3727/096368910X532738?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -