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Response to alcohol in women: role of the menstrual cycle and a family history of alcoholism.
Drug Alcohol Depend 2011; 114(1):18-30DA

Abstract

The present study determined whether: (1) the response to alcohol varied as a function of menstrual cycle phase and (2) women with a paternal history of alcoholism (FHP) were less sensitive to the effects of alcohol compared to women without a family history of alcoholism (FHN). The behavioral effects of alcohol (0.00, 0.25, and 0.75 g/kg) were evaluated in 21 FHN and 24 FHP women; each dose was tested during both the midfollicular and late luteal phases of the menstrual cycle. Baseline negative mood was increased during the luteal phase compared to the follicular phase (increased Beck Depression scores and decreased Vigor, Arousal, and Friendly scores). Alcohol increased ratings of Drug Liking and Good Drug Effect more in the luteal phase than the follicular phase. FHP women had greater negative mood during the luteal phase and some of these dysphoric effects were increased by alcohol more in FHP women than FHN women. Alcohol impaired performance, with no group or menstrual cycle differences. However, consistent with previous studies, FHP women were less impaired by alcohol than FHN women on the balance task. These data indicate that (1) the differences in response to alcohol across the menstrual cycle are subtle, although alcohol is liked more during the luteal phase; (2) increases in dysphoric mood during the luteal phase are more pronounced in FHP women compared to FHN women, particularly after alcohol; and (3) the differences observed in response to alcohol between FHP and FHN women are less pronounced than previously shown in men.

Authors+Show Affiliations

New York State Psychiatric Institute and Departmentof Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA. se18@columbia.eduNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

20888148

Citation

Evans, Suzette M., and Frances R. Levin. "Response to Alcohol in Women: Role of the Menstrual Cycle and a Family History of Alcoholism." Drug and Alcohol Dependence, vol. 114, no. 1, 2011, pp. 18-30.
Evans SM, Levin FR. Response to alcohol in women: role of the menstrual cycle and a family history of alcoholism. Drug Alcohol Depend. 2011;114(1):18-30.
Evans, S. M., & Levin, F. R. (2011). Response to alcohol in women: role of the menstrual cycle and a family history of alcoholism. Drug and Alcohol Dependence, 114(1), pp. 18-30. doi:10.1016/j.drugalcdep.2010.09.001.
Evans SM, Levin FR. Response to Alcohol in Women: Role of the Menstrual Cycle and a Family History of Alcoholism. Drug Alcohol Depend. 2011 Mar 1;114(1):18-30. PubMed PMID: 20888148.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Response to alcohol in women: role of the menstrual cycle and a family history of alcoholism. AU - Evans,Suzette M, AU - Levin,Frances R, PY - 2010/03/02/received PY - 2010/08/27/revised PY - 2010/09/01/accepted PY - 2010/10/5/entrez PY - 2010/10/5/pubmed PY - 2011/12/21/medline SP - 18 EP - 30 JF - Drug and alcohol dependence JO - Drug Alcohol Depend VL - 114 IS - 1 N2 - The present study determined whether: (1) the response to alcohol varied as a function of menstrual cycle phase and (2) women with a paternal history of alcoholism (FHP) were less sensitive to the effects of alcohol compared to women without a family history of alcoholism (FHN). The behavioral effects of alcohol (0.00, 0.25, and 0.75 g/kg) were evaluated in 21 FHN and 24 FHP women; each dose was tested during both the midfollicular and late luteal phases of the menstrual cycle. Baseline negative mood was increased during the luteal phase compared to the follicular phase (increased Beck Depression scores and decreased Vigor, Arousal, and Friendly scores). Alcohol increased ratings of Drug Liking and Good Drug Effect more in the luteal phase than the follicular phase. FHP women had greater negative mood during the luteal phase and some of these dysphoric effects were increased by alcohol more in FHP women than FHN women. Alcohol impaired performance, with no group or menstrual cycle differences. However, consistent with previous studies, FHP women were less impaired by alcohol than FHN women on the balance task. These data indicate that (1) the differences in response to alcohol across the menstrual cycle are subtle, although alcohol is liked more during the luteal phase; (2) increases in dysphoric mood during the luteal phase are more pronounced in FHP women compared to FHN women, particularly after alcohol; and (3) the differences observed in response to alcohol between FHP and FHN women are less pronounced than previously shown in men. SN - 1879-0046 UR - https://www.unboundmedicine.com/medline/citation/20888148/Response_to_alcohol_in_women:_role_of_the_menstrual_cycle_and_a_family_history_of_alcoholism_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0376-8716(10)00302-9 DB - PRIME DP - Unbound Medicine ER -