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The diagnostic and clinical significance of café-au-lait macules.
Pediatr Clin North Am. 2010 Oct; 57(5):1131-53.PC

Abstract

Café-au-lait, also referred to as café-au-lait spots or café-au-lait macules, present as well-circumscribed, evenly pigmented macules and patches that range in size from 1 to 2 mm to greater than 20 cm in greatest diameter. Café-au-lait are common in children. Although most café-au-lait present as 1 or 2 spots in an otherwise healthy child, the presence of multiple café-au-lait, large segmental café-au-lait, associated facial dysmorphism, other cutaneous anomalies, or unusual findings on physical examination should suggest the possibility of an associated syndrome. While neurofibromatosis type 1 is the most common syndrome seen in children with multiple café-au-lait, other syndromes associated with one or more café-au-lait include McCune-Albright syndrome, Legius syndrome, Noonan syndrome and other neuro-cardio-facialcutaneous syndromes, ring chromosome syndromes, and constitutional mismatch repair deficiency syndrome.

Links

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linkinghub.elsevier.com
journals.elsevierhealth.com
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Authors+Show Affiliations

Shah KN
Department of Pediatrics and Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. shahk@email.chop.edu

MeSH

Cafe-au-Lait SpotsChildChild WelfareDiagnosis, DifferentialHumansHyperpigmentationInfantInfant, NewbornNeurofibromatosis 1Nevus, PigmentedRisk FactorsSkinSkin AbnormalitiesSyndrome

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20888463

Citation

Shah, Kara N.. "The Diagnostic and Clinical Significance of Café-au-lait Macules." Pediatric Clinics of North America, vol. 57, no. 5, 2010, pp. 1131-53.
Shah KN. The diagnostic and clinical significance of café-au-lait macules. Pediatr Clin North Am. 2010;57(5):1131-53.
Shah, K. N. (2010). The diagnostic and clinical significance of café-au-lait macules. Pediatric Clinics of North America, 57(5), 1131-53. https://doi.org/10.1016/j.pcl.2010.07.002
Shah KN. The Diagnostic and Clinical Significance of Café-au-lait Macules. Pediatr Clin North Am. 2010;57(5):1131-53. PubMed PMID: 20888463.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The diagnostic and clinical significance of café-au-lait macules. A1 - Shah,Kara N, PY - 2010/10/5/entrez PY - 2010/10/5/pubmed PY - 2010/10/26/medline SP - 1131 EP - 53 JF - Pediatric clinics of North America JO - Pediatr Clin North Am VL - 57 IS - 5 N2 - Café-au-lait, also referred to as café-au-lait spots or café-au-lait macules, present as well-circumscribed, evenly pigmented macules and patches that range in size from 1 to 2 mm to greater than 20 cm in greatest diameter. Café-au-lait are common in children. Although most café-au-lait present as 1 or 2 spots in an otherwise healthy child, the presence of multiple café-au-lait, large segmental café-au-lait, associated facial dysmorphism, other cutaneous anomalies, or unusual findings on physical examination should suggest the possibility of an associated syndrome. While neurofibromatosis type 1 is the most common syndrome seen in children with multiple café-au-lait, other syndromes associated with one or more café-au-lait include McCune-Albright syndrome, Legius syndrome, Noonan syndrome and other neuro-cardio-facialcutaneous syndromes, ring chromosome syndromes, and constitutional mismatch repair deficiency syndrome. SN - 1557-8240 UR - https://www.unboundmedicine.com/medline/citation/20888463/The_diagnostic_and_clinical_significance_of_café_au_lait_macules_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0031-3955(10)00093-3 DB - PRIME DP - Unbound Medicine ER -