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Effects of ghrelin on psychopathology, sleep and secretion of cortisol and growth hormone in patients with major depression.
J Psychiatr Res. 2011 Mar; 45(3):421-6.JP

Abstract

Ghrelin showed antidepressant-like effects in mice. Furthermore, ghrelin influences sleep and the activity of hypothalamic-pituitary-adrenal (HPA) and somatotropic axis in healthy humans as indicated by increased cortisol and growth hormone (GH) plasma levels. Both sleep and the activity of these endocrine axes are disturbed in depression. We therefore studied the impact of ghrelin on psychopathology, sleep and secretion of cortisol and GH in patients with major depression. Depressive symptoms as assessed by a validated self rating scale ('Befindlichkeits-Skala', [mental state scale]), secretion profiles of cortisol and GH and sleep-EEGs were determined in 14 unmedicated patients with major depression (7 women) twice, receiving 50 μg ghrelin or placebo at 22:00, 23:00, 00:00, and 01:00 hours. Overall, depressive symptoms did not change significantly after ghrelin administration (placebo: 37 ± 8; ghrelin: 33 ± 10, p = 0.178). However, there was an improvement at trend level in men (placebo: 36 ± 9 to ghrelin: 30 ± 9, p = 0.093) but not in women. In men, ghrelin was associated with less time awake (placebo: 149.0 ± 11.1; ghrelin: 88.0 ± 12.2 min, p = 0.029) and more non-REM sleep (placebo: 263.2 ± 24.1; ghrelin: 304.9 ± 14.1 min, p = 0.027), in women with less REM sleep (placebo: 108.6 ± 15.7; ghrelin: 74.1 ± 13.8 min, p = 0.031) and longer REM latency (placebo: 49.9 ± 6.5; ghrelin: 85.6 ± 14.1 min, p = 0.019). In both sexes, ghrelin caused strong transient increases of GH and cortisol. In conclusion, our study may provide some initial indication that ghrelin can exert antidepressant effects in patients with major depression. Ghrelin strongly affected sleep and secretion of GH and cortisol in a partly different way as previously reported in healthy subjects.

Authors+Show Affiliations

Max Planck Institute of Psychiatry, Munich, Germany. michael.kluge@medizin.uni-leipzig.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20888580

Citation

Kluge, Michael, et al. "Effects of Ghrelin On Psychopathology, Sleep and Secretion of Cortisol and Growth Hormone in Patients With Major Depression." Journal of Psychiatric Research, vol. 45, no. 3, 2011, pp. 421-6.
Kluge M, Schüssler P, Dresler M, et al. Effects of ghrelin on psychopathology, sleep and secretion of cortisol and growth hormone in patients with major depression. J Psychiatr Res. 2011;45(3):421-6.
Kluge, M., Schüssler, P., Dresler, M., Schmidt, D., Yassouridis, A., Uhr, M., & Steiger, A. (2011). Effects of ghrelin on psychopathology, sleep and secretion of cortisol and growth hormone in patients with major depression. Journal of Psychiatric Research, 45(3), 421-6. https://doi.org/10.1016/j.jpsychires.2010.09.002
Kluge M, et al. Effects of Ghrelin On Psychopathology, Sleep and Secretion of Cortisol and Growth Hormone in Patients With Major Depression. J Psychiatr Res. 2011;45(3):421-6. PubMed PMID: 20888580.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of ghrelin on psychopathology, sleep and secretion of cortisol and growth hormone in patients with major depression. AU - Kluge,Michael, AU - Schüssler,Petra, AU - Dresler,Martin, AU - Schmidt,Doreen, AU - Yassouridis,Alexander, AU - Uhr,Manfred, AU - Steiger,Axel, PY - 2010/07/29/received PY - 2010/09/06/revised PY - 2010/09/06/accepted PY - 2010/10/5/entrez PY - 2010/10/5/pubmed PY - 2011/6/15/medline SP - 421 EP - 6 JF - Journal of psychiatric research JO - J Psychiatr Res VL - 45 IS - 3 N2 - Ghrelin showed antidepressant-like effects in mice. Furthermore, ghrelin influences sleep and the activity of hypothalamic-pituitary-adrenal (HPA) and somatotropic axis in healthy humans as indicated by increased cortisol and growth hormone (GH) plasma levels. Both sleep and the activity of these endocrine axes are disturbed in depression. We therefore studied the impact of ghrelin on psychopathology, sleep and secretion of cortisol and GH in patients with major depression. Depressive symptoms as assessed by a validated self rating scale ('Befindlichkeits-Skala', [mental state scale]), secretion profiles of cortisol and GH and sleep-EEGs were determined in 14 unmedicated patients with major depression (7 women) twice, receiving 50 μg ghrelin or placebo at 22:00, 23:00, 00:00, and 01:00 hours. Overall, depressive symptoms did not change significantly after ghrelin administration (placebo: 37 ± 8; ghrelin: 33 ± 10, p = 0.178). However, there was an improvement at trend level in men (placebo: 36 ± 9 to ghrelin: 30 ± 9, p = 0.093) but not in women. In men, ghrelin was associated with less time awake (placebo: 149.0 ± 11.1; ghrelin: 88.0 ± 12.2 min, p = 0.029) and more non-REM sleep (placebo: 263.2 ± 24.1; ghrelin: 304.9 ± 14.1 min, p = 0.027), in women with less REM sleep (placebo: 108.6 ± 15.7; ghrelin: 74.1 ± 13.8 min, p = 0.031) and longer REM latency (placebo: 49.9 ± 6.5; ghrelin: 85.6 ± 14.1 min, p = 0.019). In both sexes, ghrelin caused strong transient increases of GH and cortisol. In conclusion, our study may provide some initial indication that ghrelin can exert antidepressant effects in patients with major depression. Ghrelin strongly affected sleep and secretion of GH and cortisol in a partly different way as previously reported in healthy subjects. SN - 1879-1379 UR - https://www.unboundmedicine.com/medline/citation/20888580/Effects_of_ghrelin_on_psychopathology_sleep_and_secretion_of_cortisol_and_growth_hormone_in_patients_with_major_depression_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3956(10)00262-1 DB - PRIME DP - Unbound Medicine ER -