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[Microbiota and irritable bowel syndrome].
Gastroenterol Clin Biol. 2010 Sep; 34 Suppl 1:S52-6.GC

Abstract

Irritable bowel syndrome (IBS) is a multifactorial disease during which the pathophysiological role of the gut microbiota has been recently highlighted. In almost 20% of the patients, IBS is clearly a post-infectious IBS as a consequence of an acute bacterial gastroenteritis. Some papers have reported an abnormal colonic fermentation in IBS patients that could explain symptoms such as bloating and be one of the factors triggering visceral hypersensitivity. More recently, significant differences in the composition of both the luminal and mucosa-associated microbiota have been reported between both IBS patients and healthy controls and IBS subgroups while some arguments exist for a small intestinal overgrowth in a subset of IBS patients. All these arguments for a deleterious role of the gut microbiota lead to the actual discuss to consider new therapeutic options, including mainly pre- and probiotics and maybe antibiotics.

Authors+Show Affiliations

ADEN EA 4311/IFRMP 23, Department of Hepatogastroenterology and Nutrition, Regional University Hospital, Charles Nicolle Hospital, 1 Rue de Germont, Rouen Cedex, France. philippe.ducrotte@chu-rouen.fr

Pub Type(s)

English Abstract
Journal Article

Language

fre

PubMed ID

20889005

Citation

Ducrotté, P. "[Microbiota and Irritable Bowel Syndrome]." Gastroenterologie Clinique Et Biologique, vol. 34 Suppl 1, 2010, pp. S52-6.
Ducrotté P. [Microbiota and irritable bowel syndrome]. Gastroenterol Clin Biol. 2010;34 Suppl 1:S52-6.
Ducrotté, P. (2010). [Microbiota and irritable bowel syndrome]. Gastroenterologie Clinique Et Biologique, 34 Suppl 1, S52-6. https://doi.org/10.1016/S0399-8320(10)70021-X
Ducrotté P. [Microbiota and Irritable Bowel Syndrome]. Gastroenterol Clin Biol. 2010;34 Suppl 1:S52-6. PubMed PMID: 20889005.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Microbiota and irritable bowel syndrome]. A1 - Ducrotté,P, PY - 2010/10/5/entrez PY - 2010/10/5/pubmed PY - 2011/2/5/medline SP - S52 EP - 6 JF - Gastroenterologie clinique et biologique JO - Gastroenterol Clin Biol VL - 34 Suppl 1 N2 - Irritable bowel syndrome (IBS) is a multifactorial disease during which the pathophysiological role of the gut microbiota has been recently highlighted. In almost 20% of the patients, IBS is clearly a post-infectious IBS as a consequence of an acute bacterial gastroenteritis. Some papers have reported an abnormal colonic fermentation in IBS patients that could explain symptoms such as bloating and be one of the factors triggering visceral hypersensitivity. More recently, significant differences in the composition of both the luminal and mucosa-associated microbiota have been reported between both IBS patients and healthy controls and IBS subgroups while some arguments exist for a small intestinal overgrowth in a subset of IBS patients. All these arguments for a deleterious role of the gut microbiota lead to the actual discuss to consider new therapeutic options, including mainly pre- and probiotics and maybe antibiotics. SN - 0399-8320 UR - https://www.unboundmedicine.com/medline/citation/20889005/[Microbiota_and_irritable_bowel_syndrome]_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0399-8320(10)70021-X DB - PRIME DP - Unbound Medicine ER -