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Voltammetric behaviour of drotaverine hydrochloride in surfactant media and its enhancement determination in Tween-20.
Colloids Surf B Biointerfaces. 2011 Feb 01; 82(2):333-9.CS

Abstract

Simple, sensitive and rapid adsorptive voltammetric behaviour of drotaverine hydrochloride onto the HMDE has been explored and validated in surfactant media by using cyclic, differential pulse and square-wave voltammetry. Addition of Tween-20 to the drotaverine hydrochloride containing electrolyte enhances the reduction current signal. The voltammograms of the drug with Tween-20 in phosphate buffers of pH 2.5-11.0 exhibit a single well defined reduction peak which may be due to the reduction of -CC- group. The cyclic voltammetric studies indicated the reduction of drotaverine hydrochloride at the electrode surface through two electron irreversible step and diffusion-controlled. The peak current showed a linear dependence with the drug concentration over the range 0.8-7.2μgmL(-1). The calculated LOD and LOQ are 1.8 and 6.0ngmL(-1) by SWCAdSV and 8.1 and 27.2ngmL(-1) by DPCAdSV, respectively. The procedure was applied to the assay of the drug in tablet form with mean percentage recoveries of 100.2% with SWCAdSV and 99.7% with DPCAdSV. The validity of the proposed methods was further assessed by applying a standard addition technique.

Authors+Show Affiliations

School of Studies in Chemistry, Jiwaji University, Gwalior 474011, India. rajeevjain54@yahoo.co.inNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20889317

Citation

Jain, Rajeev, et al. "Voltammetric Behaviour of Drotaverine Hydrochloride in Surfactant Media and Its Enhancement Determination in Tween-20." Colloids and Surfaces. B, Biointerfaces, vol. 82, no. 2, 2011, pp. 333-9.
Jain R, Vikas , Rather JA. Voltammetric behaviour of drotaverine hydrochloride in surfactant media and its enhancement determination in Tween-20. Colloids Surf B Biointerfaces. 2011;82(2):333-9.
Jain, R., Vikas, ., & Rather, J. A. (2011). Voltammetric behaviour of drotaverine hydrochloride in surfactant media and its enhancement determination in Tween-20. Colloids and Surfaces. B, Biointerfaces, 82(2), 333-9. https://doi.org/10.1016/j.colsurfb.2010.09.005
Jain R, Vikas , Rather JA. Voltammetric Behaviour of Drotaverine Hydrochloride in Surfactant Media and Its Enhancement Determination in Tween-20. Colloids Surf B Biointerfaces. 2011 Feb 1;82(2):333-9. PubMed PMID: 20889317.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Voltammetric behaviour of drotaverine hydrochloride in surfactant media and its enhancement determination in Tween-20. AU - Jain,Rajeev, AU - Vikas,, AU - Rather,Jahangir Ahmad, Y1 - 2010/09/15/ PY - 2010/03/27/received PY - 2010/09/03/revised PY - 2010/09/05/accepted PY - 2010/10/5/entrez PY - 2010/10/5/pubmed PY - 2011/4/13/medline SP - 333 EP - 9 JF - Colloids and surfaces. B, Biointerfaces JO - Colloids Surf B Biointerfaces VL - 82 IS - 2 N2 - Simple, sensitive and rapid adsorptive voltammetric behaviour of drotaverine hydrochloride onto the HMDE has been explored and validated in surfactant media by using cyclic, differential pulse and square-wave voltammetry. Addition of Tween-20 to the drotaverine hydrochloride containing electrolyte enhances the reduction current signal. The voltammograms of the drug with Tween-20 in phosphate buffers of pH 2.5-11.0 exhibit a single well defined reduction peak which may be due to the reduction of -CC- group. The cyclic voltammetric studies indicated the reduction of drotaverine hydrochloride at the electrode surface through two electron irreversible step and diffusion-controlled. The peak current showed a linear dependence with the drug concentration over the range 0.8-7.2μgmL(-1). The calculated LOD and LOQ are 1.8 and 6.0ngmL(-1) by SWCAdSV and 8.1 and 27.2ngmL(-1) by DPCAdSV, respectively. The procedure was applied to the assay of the drug in tablet form with mean percentage recoveries of 100.2% with SWCAdSV and 99.7% with DPCAdSV. The validity of the proposed methods was further assessed by applying a standard addition technique. SN - 1873-4367 UR - https://www.unboundmedicine.com/medline/citation/20889317/Voltammetric_behaviour_of_drotaverine_hydrochloride_in_surfactant_media_and_its_enhancement_determination_in_Tween_20_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0927-7765(10)00512-6 DB - PRIME DP - Unbound Medicine ER -