Tags

Type your tag names separated by a space and hit enter

Voltammetric behaviour of drotaverine hydrochloride in surfactant media and its enhancement determination in Tween-20.
Colloids Surf B Biointerfaces. 2011 Feb 01; 82(2):333-9.CS

Abstract

Simple, sensitive and rapid adsorptive voltammetric behaviour of drotaverine hydrochloride onto the HMDE has been explored and validated in surfactant media by using cyclic, differential pulse and square-wave voltammetry. Addition of Tween-20 to the drotaverine hydrochloride containing electrolyte enhances the reduction current signal. The voltammograms of the drug with Tween-20 in phosphate buffers of pH 2.5-11.0 exhibit a single well defined reduction peak which may be due to the reduction of -CC- group. The cyclic voltammetric studies indicated the reduction of drotaverine hydrochloride at the electrode surface through two electron irreversible step and diffusion-controlled. The peak current showed a linear dependence with the drug concentration over the range 0.8-7.2μgmL(-1). The calculated LOD and LOQ are 1.8 and 6.0ngmL(-1) by SWCAdSV and 8.1 and 27.2ngmL(-1) by DPCAdSV, respectively. The procedure was applied to the assay of the drug in tablet form with mean percentage recoveries of 100.2% with SWCAdSV and 99.7% with DPCAdSV. The validity of the proposed methods was further assessed by applying a standard addition technique.

Links

Publisher Full Text

Authors+Show Affiliations

Jain R
School of Studies in Chemistry, Jiwaji University, Gwalior 474011, India. rajeevjain54@yahoo.co.in
Vikas
No affiliation info available
Rather JA
No affiliation info available

MeSH

AdsorptionCarbonChemistry, PharmaceuticalDose-Response Relationship, DrugElectrochemistryElectrodesHydrogen-Ion ConcentrationModels, ChemicalPapaverinePolysorbatesReproducibility of ResultsSurface PropertiesSurface-Active AgentsTablets

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20889317

Citation

Jain, Rajeev, et al. "Voltammetric Behaviour of Drotaverine Hydrochloride in Surfactant Media and Its Enhancement Determination in Tween-20." Colloids and Surfaces. B, Biointerfaces, vol. 82, no. 2, 2011, pp. 333-9.
Jain R, Vikas , Rather JA. Voltammetric behaviour of drotaverine hydrochloride in surfactant media and its enhancement determination in Tween-20. Colloids Surf B Biointerfaces. 2011;82(2):333-9.
Jain, R., Vikas, ., & Rather, J. A. (2011). Voltammetric behaviour of drotaverine hydrochloride in surfactant media and its enhancement determination in Tween-20. Colloids and Surfaces. B, Biointerfaces, 82(2), 333-9. https://doi.org/10.1016/j.colsurfb.2010.09.005
Jain R, Vikas , Rather JA. Voltammetric Behaviour of Drotaverine Hydrochloride in Surfactant Media and Its Enhancement Determination in Tween-20. Colloids Surf B Biointerfaces. 2011 Feb 1;82(2):333-9. PubMed PMID: 20889317.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Voltammetric behaviour of drotaverine hydrochloride in surfactant media and its enhancement determination in Tween-20. AU - Jain,Rajeev, AU - Vikas,, AU - Rather,Jahangir Ahmad, Y1 - 2010/09/15/ PY - 2010/03/27/received PY - 2010/09/03/revised PY - 2010/09/05/accepted PY - 2010/10/5/entrez PY - 2010/10/5/pubmed PY - 2011/4/13/medline SP - 333 EP - 9 JF - Colloids and surfaces. B, Biointerfaces JO - Colloids Surf B Biointerfaces VL - 82 IS - 2 N2 - Simple, sensitive and rapid adsorptive voltammetric behaviour of drotaverine hydrochloride onto the HMDE has been explored and validated in surfactant media by using cyclic, differential pulse and square-wave voltammetry. Addition of Tween-20 to the drotaverine hydrochloride containing electrolyte enhances the reduction current signal. The voltammograms of the drug with Tween-20 in phosphate buffers of pH 2.5-11.0 exhibit a single well defined reduction peak which may be due to the reduction of -CC- group. The cyclic voltammetric studies indicated the reduction of drotaverine hydrochloride at the electrode surface through two electron irreversible step and diffusion-controlled. The peak current showed a linear dependence with the drug concentration over the range 0.8-7.2μgmL(-1). The calculated LOD and LOQ are 1.8 and 6.0ngmL(-1) by SWCAdSV and 8.1 and 27.2ngmL(-1) by DPCAdSV, respectively. The procedure was applied to the assay of the drug in tablet form with mean percentage recoveries of 100.2% with SWCAdSV and 99.7% with DPCAdSV. The validity of the proposed methods was further assessed by applying a standard addition technique. SN - 1873-4367 UR - https://www.unboundmedicine.com/medline/citation/20889317/Voltammetric_behaviour_of_drotaverine_hydrochloride_in_surfactant_media_and_its_enhancement_determination_in_Tween_20_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0927-7765(10)00512-6 DB - PRIME DP - Unbound Medicine ER -