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Refractory pancytopenia and megaloblastic anemia due to falciparum malaria.
J Trop Pediatr. 2011 Aug; 57(4):283-5.JT

Abstract

Anemia is a common complication in malarial infection. Direct destruction and ineffective erythropoesis does not adequately explain the cause of anemia in malaria. We present a case with refractory megaloblastic anemia with asymptomatic falciparum malaria. We hypothesize that promoter variants in the inducible nitric oxide synthase gene might be the cause of severe refractory megaloblastic anemia and pancytopenia in our patient. Malaria should always be kept in mind as a cause of anemia especially in endemic areas even if the child is asymptomatic or there is no demonstrable parasite on routine smear examination.

Authors+Show Affiliations

Department of Pediatrics, Kalawati Saran Children's Hospital and Lady Hardinge Medical College, New Delhi, India. dranugulati@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

20889623

Citation

Aggarwal, Varun, et al. "Refractory Pancytopenia and Megaloblastic Anemia Due to Falciparum Malaria." Journal of Tropical Pediatrics, vol. 57, no. 4, 2011, pp. 283-5.
Aggarwal V, Maheshwari A, Rath B, et al. Refractory pancytopenia and megaloblastic anemia due to falciparum malaria. J Trop Pediatr. 2011;57(4):283-5.
Aggarwal, V., Maheshwari, A., Rath, B., Kumar, P., & Basu, S. (2011). Refractory pancytopenia and megaloblastic anemia due to falciparum malaria. Journal of Tropical Pediatrics, 57(4), 283-5. https://doi.org/10.1093/tropej/fmq090
Aggarwal V, et al. Refractory Pancytopenia and Megaloblastic Anemia Due to Falciparum Malaria. J Trop Pediatr. 2011;57(4):283-5. PubMed PMID: 20889623.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Refractory pancytopenia and megaloblastic anemia due to falciparum malaria. AU - Aggarwal,Varun, AU - Maheshwari,Anu, AU - Rath,Bimbadhar, AU - Kumar,Praveen, AU - Basu,Srikanta, Y1 - 2010/10/01/ PY - 2010/10/5/entrez PY - 2010/10/5/pubmed PY - 2011/12/14/medline SP - 283 EP - 5 JF - Journal of tropical pediatrics JO - J. Trop. Pediatr. VL - 57 IS - 4 N2 - Anemia is a common complication in malarial infection. Direct destruction and ineffective erythropoesis does not adequately explain the cause of anemia in malaria. We present a case with refractory megaloblastic anemia with asymptomatic falciparum malaria. We hypothesize that promoter variants in the inducible nitric oxide synthase gene might be the cause of severe refractory megaloblastic anemia and pancytopenia in our patient. Malaria should always be kept in mind as a cause of anemia especially in endemic areas even if the child is asymptomatic or there is no demonstrable parasite on routine smear examination. SN - 1465-3664 UR - https://www.unboundmedicine.com/medline/citation/20889623/Refractory_pancytopenia_and_megaloblastic_anemia_due_to_falciparum_malaria_ L2 - https://academic.oup.com/tropej/article-lookup/doi/10.1093/tropej/fmq090 DB - PRIME DP - Unbound Medicine ER -