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Impact of restrictive physiology on intrinsic diastolic right ventricular function and lusitropy in children and adolescents after repair of tetralogy of Fallot.
Heart. 2010 Nov; 96(22):1837-41.H

Abstract

BACKGROUND

Restrictive right ventricular (RV) physiology is a phenomenon considered potentially beneficial when detected in children and adolescents with repaired tetralogy of Fallot (ToF). It is typically characterised by antegrade flow in the pulmonary artery in late diastole at the time of atrial contraction. However, little is known about the impact of restrictive physiology on intrinsic diastolic RV function or lusitropy.

METHODS

Diastolic function was prospectively assessed at baseline level and during dobutamine infusion using the pressure-volume conductance system. End diastolic forward flow in the pulmonary artery was measured by MRI.

RESULTS

Twenty-five patients aged 17.9±7.5 years were studied. Although the end diastolic RV pressure, the time constant of isovolumic RV relaxation (τ) and dP/dtmin were similar between both groups, the slope of the end diastolic pressure-volume relationship (Eed) was significantly higher in the restrictive group indicating increased diastolic stiffness in these patients (0.14±0.05 vs 0.06±0.01, p=0.03). Dobutamine stress, however, led to an increase in Eed in the entire ToF cohort indicating an abnormal diastolic response to catecholamines in these patients.

CONCLUSIONS

Diastolic RV stiffness of repaired ToF patients with restrictive physiology is increased. The lusitropic response of the RV to β adrenergic agents is abnormal after ToF repair regardless of whether restrictive physiology is present or not. This has potential implications, particularly for postoperative drug management.

Authors+Show Affiliations

Division of Pediatric Cardiology, University Children’s Hospital, Tuebingen, Germany. capitz@aol.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20889987

Citation

Apitz, Christian, et al. "Impact of Restrictive Physiology On Intrinsic Diastolic Right Ventricular Function and Lusitropy in Children and Adolescents After Repair of Tetralogy of Fallot." Heart (British Cardiac Society), vol. 96, no. 22, 2010, pp. 1837-41.
Apitz C, Latus H, Binder W, et al. Impact of restrictive physiology on intrinsic diastolic right ventricular function and lusitropy in children and adolescents after repair of tetralogy of Fallot. Heart. 2010;96(22):1837-41.
Apitz, C., Latus, H., Binder, W., Uebing, A., Seeger, A., Bretschneider, C., Sieverding, L., & Hofbeck, M. (2010). Impact of restrictive physiology on intrinsic diastolic right ventricular function and lusitropy in children and adolescents after repair of tetralogy of Fallot. Heart (British Cardiac Society), 96(22), 1837-41. https://doi.org/10.1136/hrt.2010.203190
Apitz C, et al. Impact of Restrictive Physiology On Intrinsic Diastolic Right Ventricular Function and Lusitropy in Children and Adolescents After Repair of Tetralogy of Fallot. Heart. 2010;96(22):1837-41. PubMed PMID: 20889987.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of restrictive physiology on intrinsic diastolic right ventricular function and lusitropy in children and adolescents after repair of tetralogy of Fallot. AU - Apitz,Christian, AU - Latus,Heiner, AU - Binder,Wolfhard, AU - Uebing,Anselm, AU - Seeger,Achim, AU - Bretschneider,Christiane, AU - Sieverding,Ludger, AU - Hofbeck,Michael, Y1 - 2010/10/03/ PY - 2010/10/5/entrez PY - 2010/10/5/pubmed PY - 2011/5/17/medline SP - 1837 EP - 41 JF - Heart (British Cardiac Society) JO - Heart VL - 96 IS - 22 N2 - BACKGROUND: Restrictive right ventricular (RV) physiology is a phenomenon considered potentially beneficial when detected in children and adolescents with repaired tetralogy of Fallot (ToF). It is typically characterised by antegrade flow in the pulmonary artery in late diastole at the time of atrial contraction. However, little is known about the impact of restrictive physiology on intrinsic diastolic RV function or lusitropy. METHODS: Diastolic function was prospectively assessed at baseline level and during dobutamine infusion using the pressure-volume conductance system. End diastolic forward flow in the pulmonary artery was measured by MRI. RESULTS: Twenty-five patients aged 17.9±7.5 years were studied. Although the end diastolic RV pressure, the time constant of isovolumic RV relaxation (τ) and dP/dtmin were similar between both groups, the slope of the end diastolic pressure-volume relationship (Eed) was significantly higher in the restrictive group indicating increased diastolic stiffness in these patients (0.14±0.05 vs 0.06±0.01, p=0.03). Dobutamine stress, however, led to an increase in Eed in the entire ToF cohort indicating an abnormal diastolic response to catecholamines in these patients. CONCLUSIONS: Diastolic RV stiffness of repaired ToF patients with restrictive physiology is increased. The lusitropic response of the RV to β adrenergic agents is abnormal after ToF repair regardless of whether restrictive physiology is present or not. This has potential implications, particularly for postoperative drug management. SN - 1468-201X UR - https://www.unboundmedicine.com/medline/citation/20889987/Impact_of_restrictive_physiology_on_intrinsic_diastolic_right_ventricular_function_and_lusitropy_in_children_and_adolescents_after_repair_of_tetralogy_of_Fallot_ L2 - http://heart.bmj.com/cgi/pmidlookup?view=long&pmid=20889987 DB - PRIME DP - Unbound Medicine ER -