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Metabolic syndrome, insulin resistance and systemic inflammation as risk factors for reduced lung function in Korean nonsmoking males.

Abstract

The aim of this study was done to assess the association of lung function with insulin resistance (IR), systemic inflammation, and metabolic syndrome (MetS). In 9,581 apparently healthy non-smoking male adults, pulmonary function, fasting glucose, insulin, lipid profiles and serum high-sensitivity C-reactive protein (hs-CRP) levels were measured, and homeostatic model assessment (HOMA) was used to assess IR. The presence of MetS was defined according to the AHA/NHLBI criteria. The prevalence of MetS was 19.3%. The odds ratio of MetS for restrictive ventilatory pattern was 1.55 (95% confidence interval, 1.12-2.14), and that for obstructive ventilatory pattern was 1.39 (0.66-2.94) after adjustment for confounders. When subjects were divided in 4 groups according to quartiles of FVC or FEV(1) (% predicted [pred]), HOMA-IR significantly increased as the FVC or FEV(1) (% predicted [pred]) decreased. Individuals in the lowest FVC or FEV(1) quartile had the highest hs-CRP level. Prevalence of MetS increased as FVC or FEV(1) (% predicted [pred]) quartiles decreased. The abdominal obesity, hs-CRP and HOMA-IR were the independent predictors for the lowest FVC and FEV(1) (% predicted [pred]) even after adjustment for confounders. These results indicate that MetS, IR, and systemic inflammation are important risk factors for reduced lung function in nonsmoking Korean males.

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  • Authors+Show Affiliations

    ,

    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.

    ,

    Source

    Journal of Korean medical science 25:10 2010 Oct pg 1480-6

    MeSH

    Adult
    C-Reactive Protein
    Forced Expiratory Volume
    Glucose
    Humans
    Inflammation
    Insulin
    Insulin Resistance
    Male
    Metabolic Syndrome
    Middle Aged
    Obesity
    Odds Ratio
    Pulmonary Ventilation
    Republic of Korea
    Respiratory Function Tests
    Risk Factors
    Vital Capacity

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    20890430

    Citation

    Lim, Seong Yong, et al. "Metabolic Syndrome, Insulin Resistance and Systemic Inflammation as Risk Factors for Reduced Lung Function in Korean Nonsmoking Males." Journal of Korean Medical Science, vol. 25, no. 10, 2010, pp. 1480-6.
    Lim SY, Rhee EJ, Sung KC. Metabolic syndrome, insulin resistance and systemic inflammation as risk factors for reduced lung function in Korean nonsmoking males. J Korean Med Sci. 2010;25(10):1480-6.
    Lim, S. Y., Rhee, E. J., & Sung, K. C. (2010). Metabolic syndrome, insulin resistance and systemic inflammation as risk factors for reduced lung function in Korean nonsmoking males. Journal of Korean Medical Science, 25(10), pp. 1480-6. doi:10.3346/jkms.2010.25.10.1480.
    Lim SY, Rhee EJ, Sung KC. Metabolic Syndrome, Insulin Resistance and Systemic Inflammation as Risk Factors for Reduced Lung Function in Korean Nonsmoking Males. J Korean Med Sci. 2010;25(10):1480-6. PubMed PMID: 20890430.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Metabolic syndrome, insulin resistance and systemic inflammation as risk factors for reduced lung function in Korean nonsmoking males. AU - Lim,Seong Yong, AU - Rhee,Eun-Jung, AU - Sung,Ki-Chul, Y1 - 2010/09/17/ PY - 2010/01/29/received PY - 2010/04/21/accepted PY - 2010/10/5/entrez PY - 2010/10/5/pubmed PY - 2011/2/18/medline KW - Insulin Resistance KW - Lung Function KW - Metabolic Syndrome KW - Obesity KW - Systemic Inflammation SP - 1480 EP - 6 JF - Journal of Korean medical science JO - J. Korean Med. Sci. VL - 25 IS - 10 N2 - The aim of this study was done to assess the association of lung function with insulin resistance (IR), systemic inflammation, and metabolic syndrome (MetS). In 9,581 apparently healthy non-smoking male adults, pulmonary function, fasting glucose, insulin, lipid profiles and serum high-sensitivity C-reactive protein (hs-CRP) levels were measured, and homeostatic model assessment (HOMA) was used to assess IR. The presence of MetS was defined according to the AHA/NHLBI criteria. The prevalence of MetS was 19.3%. The odds ratio of MetS for restrictive ventilatory pattern was 1.55 (95% confidence interval, 1.12-2.14), and that for obstructive ventilatory pattern was 1.39 (0.66-2.94) after adjustment for confounders. When subjects were divided in 4 groups according to quartiles of FVC or FEV(1) (% predicted [pred]), HOMA-IR significantly increased as the FVC or FEV(1) (% predicted [pred]) decreased. Individuals in the lowest FVC or FEV(1) quartile had the highest hs-CRP level. Prevalence of MetS increased as FVC or FEV(1) (% predicted [pred]) quartiles decreased. The abdominal obesity, hs-CRP and HOMA-IR were the independent predictors for the lowest FVC and FEV(1) (% predicted [pred]) even after adjustment for confounders. These results indicate that MetS, IR, and systemic inflammation are important risk factors for reduced lung function in nonsmoking Korean males. SN - 1598-6357 UR - https://www.unboundmedicine.com/medline/citation/20890430/Metabolic_syndrome_insulin_resistance_and_systemic_inflammation_as_risk_factors_for_reduced_lung_function_in_Korean_nonsmoking_males_ L2 - https://jkms.org/DOIx.php?id=10.3346/jkms.2010.25.10.1480 DB - PRIME DP - Unbound Medicine ER -