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Microbiological transformation of chromone, chromanone, and ring A hydroxyflavones.
J Nat Prod. 1990 Nov-Dec; 53(6):1471-8.JN

Abstract

Microbial transformation of chromone, chromanone, and 3 ring A hydroxyflavones (5-hydroxy-, 6-hydroxy-, and 7-hydroxyflavones) was attempted using thirty-two microorganisms. While chromone was not biotransformed, chromanone was transformed to chromone and chromanol by Aspergillus niger in 2% yield. Ring A hydroxylated flavones were transformed to the corresponding C-4' hydroxylated metabolites, and the yields and rate of product formation were found to correlate with the distance between the C-4 carbonyl group and the hydroxyl group in ring A.

Authors+Show Affiliations

Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis 55455.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2089118

Citation

Ibrahim, A R., and Y J. Abul-Hajj. "Microbiological Transformation of Chromone, Chromanone, and Ring a Hydroxyflavones." Journal of Natural Products, vol. 53, no. 6, 1990, pp. 1471-8.
Ibrahim AR, Abul-Hajj YJ. Microbiological transformation of chromone, chromanone, and ring A hydroxyflavones. J Nat Prod. 1990;53(6):1471-8.
Ibrahim, A. R., & Abul-Hajj, Y. J. (1990). Microbiological transformation of chromone, chromanone, and ring A hydroxyflavones. Journal of Natural Products, 53(6), 1471-8.
Ibrahim AR, Abul-Hajj YJ. Microbiological Transformation of Chromone, Chromanone, and Ring a Hydroxyflavones. J Nat Prod. 1990 Nov-Dec;53(6):1471-8. PubMed PMID: 2089118.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Microbiological transformation of chromone, chromanone, and ring A hydroxyflavones. AU - Ibrahim,A R, AU - Abul-Hajj,Y J, PY - 1990/11/1/pubmed PY - 1990/11/1/medline PY - 1990/11/1/entrez SP - 1471 EP - 8 JF - Journal of natural products JO - J. Nat. Prod. VL - 53 IS - 6 N2 - Microbial transformation of chromone, chromanone, and 3 ring A hydroxyflavones (5-hydroxy-, 6-hydroxy-, and 7-hydroxyflavones) was attempted using thirty-two microorganisms. While chromone was not biotransformed, chromanone was transformed to chromone and chromanol by Aspergillus niger in 2% yield. Ring A hydroxylated flavones were transformed to the corresponding C-4' hydroxylated metabolites, and the yields and rate of product formation were found to correlate with the distance between the C-4 carbonyl group and the hydroxyl group in ring A. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/2089118/Microbiological_transformation_of_chromone_chromanone_and_ring_A_hydroxyflavones_ L2 - https://medlineplus.gov/molds.html DB - PRIME DP - Unbound Medicine ER -