Tags

Type your tag names separated by a space and hit enter

Precipitins in bird breeder's disease: how useful are they?
Eur Respir J. 1990 Nov; 3(10):1155-61.ER

Abstract

Precipitating antibodies to avian antigens play a controversial role in the diagnosis of bird breeder's disease (BBD). In order to establish the sensitivity, specificity and accuracy of precipitins in our laboratory, we conducted a prospective study including 128 sera received in 1988 for determination, by immunoelectrophoresis, of avian precipitins. Accurate information was obtained for 90 patients; definitive clinical diagnosis was given by the patient's own physician. We found a high sensitivity (86%), specificity (93%) and accuracy (92%) of avian precipitins in the diagnosis of BBD. Bayes' theorem was applied to determine the predictive value of the test with varying disease prevalence, and established that precipitins were particularly valuable for low or medium a priori probability. Using the receiver operating characteristic (ROC) curve we evaluated the effects of varying the positivity threshold of precipitins. The threshold used in this study appeared to offer the best compromise between sensitivity and specificity. These results suggest that the diagnostic value of avian precipitins in the work-up of BBD should be reconsidered, also because they represent a simple, cheap and non-invasive diagnostic test.

Authors+Show Affiliations

Laboratory of Pulmonary Immunology, University Hospital, Geneva, Switzerland.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2090477

Citation

Reynaud, C, et al. "Precipitins in Bird Breeder's Disease: How Useful Are They?" The European Respiratory Journal, vol. 3, no. 10, 1990, pp. 1155-61.
Reynaud C, Slosman DO, Polla BS. Precipitins in bird breeder's disease: how useful are they? Eur Respir J. 1990;3(10):1155-61.
Reynaud, C., Slosman, D. O., & Polla, B. S. (1990). Precipitins in bird breeder's disease: how useful are they? The European Respiratory Journal, 3(10), 1155-61.
Reynaud C, Slosman DO, Polla BS. Precipitins in Bird Breeder's Disease: How Useful Are They. Eur Respir J. 1990;3(10):1155-61. PubMed PMID: 2090477.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Precipitins in bird breeder's disease: how useful are they? AU - Reynaud,C, AU - Slosman,D O, AU - Polla,B S, PY - 1990/11/1/pubmed PY - 1990/11/1/medline PY - 1990/11/1/entrez SP - 1155 EP - 61 JF - The European respiratory journal JO - Eur Respir J VL - 3 IS - 10 N2 - Precipitating antibodies to avian antigens play a controversial role in the diagnosis of bird breeder's disease (BBD). In order to establish the sensitivity, specificity and accuracy of precipitins in our laboratory, we conducted a prospective study including 128 sera received in 1988 for determination, by immunoelectrophoresis, of avian precipitins. Accurate information was obtained for 90 patients; definitive clinical diagnosis was given by the patient's own physician. We found a high sensitivity (86%), specificity (93%) and accuracy (92%) of avian precipitins in the diagnosis of BBD. Bayes' theorem was applied to determine the predictive value of the test with varying disease prevalence, and established that precipitins were particularly valuable for low or medium a priori probability. Using the receiver operating characteristic (ROC) curve we evaluated the effects of varying the positivity threshold of precipitins. The threshold used in this study appeared to offer the best compromise between sensitivity and specificity. These results suggest that the diagnostic value of avian precipitins in the work-up of BBD should be reconsidered, also because they represent a simple, cheap and non-invasive diagnostic test. SN - 0903-1936 UR - https://www.unboundmedicine.com/medline/citation/2090477/Precipitins_in_bird_breeder's_disease:_how_useful_are_they DB - PRIME DP - Unbound Medicine ER -