Tags

Type your tag names separated by a space and hit enter

Evaluation of red cell deformability by a filtration method in type 1 and type 2 diabetes mellitus with and without vascular complications.
Diabetes Res 1990; 13(2):61-5DR

Abstract

Previous studies of red cell deformability (RCD) in diabetic patients have produced conflicting results. We have therefore reassessed this problem with the Carri-Med Filtrometer, which measures RCD independently of the rate of clogging of the filter. The initial red cell filtration ratio relative to buffer (mean +/- SD) of 69 diabetic patients (28 type 1 and 41 type 2) was significantly impaired in both type 1 (0.470 +/- 0.047) and type 2 diabetic patients (0.488 +/- 0.065), when compared to 66 non diabetic control subjects (0.540 +/- 0.032; both p less than 0.001). A significant difference in RCD was noted between type 1 and type 2 diabetics (p less than 0.03), but no association with vascular complications was found. No significant correlations were noted between RCD and the duration of diabetes, age, HbA1, leucocyte count, or mean red cell volume. However RCD was inversely related to mean red cell haemoglobin concentration (r = -0.43, p less than 0.01). Diabetics had significantly lower mean red cell volume and significantly higher mean cell haemoglobin concentration than non-diabetics, but these changes could not explain the difference in RCD, which may be related to alterations in the red cell membrane.

Authors+Show Affiliations

Diabetic Clinic, Royal Infirmary, Glasgow, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

2091871

Citation

MacRury, S M., et al. "Evaluation of Red Cell Deformability By a Filtration Method in Type 1 and Type 2 Diabetes Mellitus With and Without Vascular Complications." Diabetes Research (Edinburgh, Scotland), vol. 13, no. 2, 1990, pp. 61-5.
MacRury SM, Small M, Anderson J, et al. Evaluation of red cell deformability by a filtration method in type 1 and type 2 diabetes mellitus with and without vascular complications. Diabetes Res. 1990;13(2):61-5.
MacRury, S. M., Small, M., Anderson, J., MacCuish, A. C., & Lowe, G. D. (1990). Evaluation of red cell deformability by a filtration method in type 1 and type 2 diabetes mellitus with and without vascular complications. Diabetes Research (Edinburgh, Scotland), 13(2), pp. 61-5.
MacRury SM, et al. Evaluation of Red Cell Deformability By a Filtration Method in Type 1 and Type 2 Diabetes Mellitus With and Without Vascular Complications. Diabetes Res. 1990;13(2):61-5. PubMed PMID: 2091871.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of red cell deformability by a filtration method in type 1 and type 2 diabetes mellitus with and without vascular complications. AU - MacRury,S M, AU - Small,M, AU - Anderson,J, AU - MacCuish,A C, AU - Lowe,G D, PY - 1990/2/1/pubmed PY - 1990/2/1/medline PY - 1990/2/1/entrez SP - 61 EP - 5 JF - Diabetes research (Edinburgh, Scotland) JO - Diabetes Res. VL - 13 IS - 2 N2 - Previous studies of red cell deformability (RCD) in diabetic patients have produced conflicting results. We have therefore reassessed this problem with the Carri-Med Filtrometer, which measures RCD independently of the rate of clogging of the filter. The initial red cell filtration ratio relative to buffer (mean +/- SD) of 69 diabetic patients (28 type 1 and 41 type 2) was significantly impaired in both type 1 (0.470 +/- 0.047) and type 2 diabetic patients (0.488 +/- 0.065), when compared to 66 non diabetic control subjects (0.540 +/- 0.032; both p less than 0.001). A significant difference in RCD was noted between type 1 and type 2 diabetics (p less than 0.03), but no association with vascular complications was found. No significant correlations were noted between RCD and the duration of diabetes, age, HbA1, leucocyte count, or mean red cell volume. However RCD was inversely related to mean red cell haemoglobin concentration (r = -0.43, p less than 0.01). Diabetics had significantly lower mean red cell volume and significantly higher mean cell haemoglobin concentration than non-diabetics, but these changes could not explain the difference in RCD, which may be related to alterations in the red cell membrane. SN - 0265-5985 UR - https://www.unboundmedicine.com/medline/citation/2091871/Evaluation_of_red_cell_deformability_by_a_filtration_method_in_type_1_and_type_2_diabetes_mellitus_with_and_without_vascular_complications_ L2 - http://www.diseaseinfosearch.org/result/8215 DB - PRIME DP - Unbound Medicine ER -