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Abnormal electrochemical skin conductance in cystic fibrosis.
J Cyst Fibros. 2011 Jan; 10(1):15-20.JC

Abstract

BACKGROUND

Electrochemical skin conductance measurement is an active electrophysiologic method in which incremental low direct voltage is applied on the skin. It generates a current due to reverse iontophoresis which previous studies suggested to be mostly related to chloride anion movements. As sweat chloride movements upon electric stimulation were likely to be impaired in cystic fibrosis (CF) patients, we designed a proof-of-concept study to measure electrochemical skin conductance in CF patients and control subjects and to test the ability of this method to discriminate CF from controls.

METHODS

Electrochemical skin conductance was measured in 41 adult patients with classical CF and 20 healthy control subjects. Patients placed their hands and feet on nickel electrodes and an incremental low direct voltage was applied on the anode during 2min. The resulting voltage on the cathode and the current generated between anode and cathode were measured and from them, two electrochemical skin conductance variables were calculated: ESC, obtained when a low voltage of 1.6V was applied, and dESC which took into account electrochemical skin conductances obtained when low and high voltages were applied.

RESULTS

ESC measurements on hands and feet were significantly different in CF patients (on feet: 75±10μSi), as compared with control subjects (62±13μSi, p<0.0001); dESC was also significantly different and more discriminative in CF patients (on feet: 34±24μSi), as compared with control subjects (93±24μSi, p<0.0001). dESC measurement provided a diagnostic specificity of 1 and a sensitivity of 0.93.

CONCLUSIONS

These results show that electrochemical skin conductance which is easily and rapidly measured is abnormal in CF patients. Trial registry name in the European Clinical Trials Database (eudraCT): "EZSCAN MUCO1: Mesure de la conductance cutanée par chronoampérométrie", N°EUDRACT: 2007-A00221-52.

Authors+Show Affiliations

Service de Pneumologie, AP-HP, Hôpital Cochin, Paris, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Validation Study

Language

eng

PubMed ID

20920895

Citation

Hubert, Dominique, et al. "Abnormal Electrochemical Skin Conductance in Cystic Fibrosis." Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society, vol. 10, no. 1, 2011, pp. 15-20.
Hubert D, Brunswick P, Calvet JH, et al. Abnormal electrochemical skin conductance in cystic fibrosis. J Cyst Fibros. 2011;10(1):15-20.
Hubert, D., Brunswick, P., Calvet, J. H., Dusser, D., & Fajac, I. (2011). Abnormal electrochemical skin conductance in cystic fibrosis. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society, 10(1), 15-20. https://doi.org/10.1016/j.jcf.2010.09.002
Hubert D, et al. Abnormal Electrochemical Skin Conductance in Cystic Fibrosis. J Cyst Fibros. 2011;10(1):15-20. PubMed PMID: 20920895.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Abnormal electrochemical skin conductance in cystic fibrosis. AU - Hubert,Dominique, AU - Brunswick,Philippe, AU - Calvet,Jean-Henri, AU - Dusser,Daniel, AU - Fajac,Isabelle, PY - 2010/02/24/received PY - 2010/09/01/revised PY - 2010/09/04/accepted PY - 2010/10/6/entrez PY - 2010/10/6/pubmed PY - 2011/5/4/medline SP - 15 EP - 20 JF - Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society JO - J. Cyst. Fibros. VL - 10 IS - 1 N2 - BACKGROUND: Electrochemical skin conductance measurement is an active electrophysiologic method in which incremental low direct voltage is applied on the skin. It generates a current due to reverse iontophoresis which previous studies suggested to be mostly related to chloride anion movements. As sweat chloride movements upon electric stimulation were likely to be impaired in cystic fibrosis (CF) patients, we designed a proof-of-concept study to measure electrochemical skin conductance in CF patients and control subjects and to test the ability of this method to discriminate CF from controls. METHODS: Electrochemical skin conductance was measured in 41 adult patients with classical CF and 20 healthy control subjects. Patients placed their hands and feet on nickel electrodes and an incremental low direct voltage was applied on the anode during 2min. The resulting voltage on the cathode and the current generated between anode and cathode were measured and from them, two electrochemical skin conductance variables were calculated: ESC, obtained when a low voltage of 1.6V was applied, and dESC which took into account electrochemical skin conductances obtained when low and high voltages were applied. RESULTS: ESC measurements on hands and feet were significantly different in CF patients (on feet: 75±10μSi), as compared with control subjects (62±13μSi, p<0.0001); dESC was also significantly different and more discriminative in CF patients (on feet: 34±24μSi), as compared with control subjects (93±24μSi, p<0.0001). dESC measurement provided a diagnostic specificity of 1 and a sensitivity of 0.93. CONCLUSIONS: These results show that electrochemical skin conductance which is easily and rapidly measured is abnormal in CF patients. Trial registry name in the European Clinical Trials Database (eudraCT): "EZSCAN MUCO1: Mesure de la conductance cutanée par chronoampérométrie", N°EUDRACT: 2007-A00221-52. SN - 1873-5010 UR - https://www.unboundmedicine.com/medline/citation/20920895/Abnormal_electrochemical_skin_conductance_in_cystic_fibrosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1569-1993(10)00137-2 DB - PRIME DP - Unbound Medicine ER -