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Role of ghrelin and insulin-like growth factor binding protein-3 in the development of osteoporosis in inflammatory bowel disease.
J Clin Gastroenterol. 2011 Jul; 45(6):e60-5.JC

Abstract

BACKGROUND

A high prevalence of bone loss is observed in patients with inflammatory bowel disease (IBD). Leptin, ghrelin, insulin-like growth factor (IGF)-1, and IGF binding protein (IGFBP)-3 have been suggested to interfere in the bone metabolism. The aim of this study was to investigate the role of these peptides in the development of osteoporosis in IBD.

METHODS

One hundred and eighteen consecutive IBD patients were included. All patients underwent bone densitometry by dual energy x-ray absorptiometry at the femoral neck and lumbar spine levels. Serum samples were collected from all patients and analyzed for concentrations of the aforementioned peptides by radioimmunoassay.

RESULTS

Forty (33.9%) patients were normal, 55 (46.6%) were osteopenic, and 23 (19.5%) were osteoporotic. Positive statistically significant correlations were found between body mass index (BMI), leptin, IGFBP-3 levels, and the bone mineral density (BMD) of the femoral neck and lumbar spine. Moreover, an inverse statistically significant correlation was found between BMD of the femoral neck and the lumbar spine, and age, duration of the disease, and ghrelin levels. Multivariate analysis revealed that the most significant factors associated with the BMD were age and BMI. A weak but statistically significant correlation was found between IGFBP-3 and femoral neck BMD (P=0.045) and between ghrelin and spine BMD (P=0.039). No correlation was observed between leptin and BMD.

CONCLUSIONS

Low BMI is the most important independent risk factor for osteoporosis in IBD patients. There is no independent influence of leptin but ghrelin and IGFBP-3 may play a role in the bone metabolism in the IBD.

Authors+Show Affiliations

Department of Gastroenterology, University Hospital of Heraklion, Crete, Greece. ikoutroub@med.uoc.grNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20921904

Citation

Koutroubakis, Ioannis E., et al. "Role of Ghrelin and Insulin-like Growth Factor Binding Protein-3 in the Development of Osteoporosis in Inflammatory Bowel Disease." Journal of Clinical Gastroenterology, vol. 45, no. 6, 2011, pp. e60-5.
Koutroubakis IE, Zavos C, Damilakis J, et al. Role of ghrelin and insulin-like growth factor binding protein-3 in the development of osteoporosis in inflammatory bowel disease. J Clin Gastroenterol. 2011;45(6):e60-5.
Koutroubakis, I. E., Zavos, C., Damilakis, J., Papadakis, G., Neratzoulakis, J., Karkavitsas, N., & Kouroumalis, E. A. (2011). Role of ghrelin and insulin-like growth factor binding protein-3 in the development of osteoporosis in inflammatory bowel disease. Journal of Clinical Gastroenterology, 45(6), e60-5. https://doi.org/10.1097/MCG.0b013e3181f42543
Koutroubakis IE, et al. Role of Ghrelin and Insulin-like Growth Factor Binding Protein-3 in the Development of Osteoporosis in Inflammatory Bowel Disease. J Clin Gastroenterol. 2011;45(6):e60-5. PubMed PMID: 20921904.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of ghrelin and insulin-like growth factor binding protein-3 in the development of osteoporosis in inflammatory bowel disease. AU - Koutroubakis,Ioannis E, AU - Zavos,Christos, AU - Damilakis,John, AU - Papadakis,Georgios, AU - Neratzoulakis,John, AU - Karkavitsas,Nikolaos, AU - Kouroumalis,Elias A, PY - 2010/10/6/entrez PY - 2010/10/6/pubmed PY - 2011/10/18/medline SP - e60 EP - 5 JF - Journal of clinical gastroenterology JO - J. Clin. Gastroenterol. VL - 45 IS - 6 N2 - BACKGROUND: A high prevalence of bone loss is observed in patients with inflammatory bowel disease (IBD). Leptin, ghrelin, insulin-like growth factor (IGF)-1, and IGF binding protein (IGFBP)-3 have been suggested to interfere in the bone metabolism. The aim of this study was to investigate the role of these peptides in the development of osteoporosis in IBD. METHODS: One hundred and eighteen consecutive IBD patients were included. All patients underwent bone densitometry by dual energy x-ray absorptiometry at the femoral neck and lumbar spine levels. Serum samples were collected from all patients and analyzed for concentrations of the aforementioned peptides by radioimmunoassay. RESULTS: Forty (33.9%) patients were normal, 55 (46.6%) were osteopenic, and 23 (19.5%) were osteoporotic. Positive statistically significant correlations were found between body mass index (BMI), leptin, IGFBP-3 levels, and the bone mineral density (BMD) of the femoral neck and lumbar spine. Moreover, an inverse statistically significant correlation was found between BMD of the femoral neck and the lumbar spine, and age, duration of the disease, and ghrelin levels. Multivariate analysis revealed that the most significant factors associated with the BMD were age and BMI. A weak but statistically significant correlation was found between IGFBP-3 and femoral neck BMD (P=0.045) and between ghrelin and spine BMD (P=0.039). No correlation was observed between leptin and BMD. CONCLUSIONS: Low BMI is the most important independent risk factor for osteoporosis in IBD patients. There is no independent influence of leptin but ghrelin and IGFBP-3 may play a role in the bone metabolism in the IBD. SN - 1539-2031 UR - https://www.unboundmedicine.com/medline/citation/20921904/Role_of_ghrelin_and_insulin_like_growth_factor_binding_protein_3_in_the_development_of_osteoporosis_in_inflammatory_bowel_disease_ L2 - http://dx.doi.org/10.1097/MCG.0b013e3181f42543 DB - PRIME DP - Unbound Medicine ER -