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Lipid peroxidation in patients with schizophrenia.

Abstract

AIMS

There is evidence that dysregulation of free radicals metabolism associated with abnormal activities of antioxidative enzymes in schizophrenia can lead to lipid peroxidation in plasma, erythrocytes, blood platelets and cerebrospinal fluid. Injury to neurons in schizophrenia may affect their function, i.e. membrane transport, impairment of energy production in mitochondria, changes in membrane phospholipid composition, alteration of receptors and transporters as well as neurotransmission. The purpose of the present study was to assess the total antioxidant capacity (TAC) and lipid peroxidation (expressed as the level of thiobarbituric acid reactive substances [TBARS]) in plasma from schizophrenic patients taking olanzapine or risperidone. The level of TBARS estimated according to the Rice-Evans method and TAC ([ABTS; 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) radical cation decolorization assay]) in plasma from schizophrenic patients (DSM-IV criteria for schizophrenia, n = 30, age 18-36) taking olanzapine or risperidone and from healthy volunteers (n = 30) were measured.

METHODS

The level of TBARS in plasma from healthy volunteers after incubation with olanzapine or risperidone was also estimated.

RESULTS

Significantly lower plasma TAC (P < 0.05) and significantly increased level of TBARS (P < 0.001) in schizophrenic patients were observed. The in vitro study showed that after olanzapine or risperidone (at final concentrations corresponding to doses used in acute episodes of schizophrenia treatment) no changes of plasma lipid peroxidation were found (P > 0.05). The obtained results indicate that the pro-oxidant disturbances occur in schizophrenic patients (acute episode) taking stable doses of olanzapine or risperidone.

CONCLUSION

It seems that second-generation antipsychotics (olanzapine and risperidone) are not responsible for increase of plasma lipid peroxidation.

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  • Authors+Show Affiliations

    ,

    Department of Affective and Psychotic Disorders, Medical University of Lodz, Lodz, Poland. tzn_lodz@post.pl

    Source

    MeSH

    Adolescent
    Adult
    Antioxidants
    Antipsychotic Agents
    Benzodiazepines
    Benzothiazoles
    Biomarkers
    Diagnostic and Statistical Manual of Mental Disorders
    Female
    Humans
    Lipid Peroxidation
    Male
    Olanzapine
    Oxidative Stress
    Risperidone
    Schizophrenia
    Sulfonic Acids
    Thiobarbituric Acid Reactive Substances
    Young Adult

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    20923426

    Citation

    Dietrich-Muszalska, Anna, and Bogdan Kontek. "Lipid Peroxidation in Patients With Schizophrenia." Psychiatry and Clinical Neurosciences, vol. 64, no. 5, 2010, pp. 469-75.
    Dietrich-Muszalska A, Kontek B. Lipid peroxidation in patients with schizophrenia. Psychiatry Clin Neurosci. 2010;64(5):469-75.
    Dietrich-Muszalska, A., & Kontek, B. (2010). Lipid peroxidation in patients with schizophrenia. Psychiatry and Clinical Neurosciences, 64(5), pp. 469-75. doi:10.1111/j.1440-1819.2010.02132.x.
    Dietrich-Muszalska A, Kontek B. Lipid Peroxidation in Patients With Schizophrenia. Psychiatry Clin Neurosci. 2010;64(5):469-75. PubMed PMID: 20923426.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Lipid peroxidation in patients with schizophrenia. AU - Dietrich-Muszalska,Anna, AU - Kontek,Bogdan, PY - 2010/10/7/entrez PY - 2010/10/7/pubmed PY - 2011/1/22/medline SP - 469 EP - 75 JF - Psychiatry and clinical neurosciences JO - Psychiatry Clin. Neurosci. VL - 64 IS - 5 N2 - AIMS: There is evidence that dysregulation of free radicals metabolism associated with abnormal activities of antioxidative enzymes in schizophrenia can lead to lipid peroxidation in plasma, erythrocytes, blood platelets and cerebrospinal fluid. Injury to neurons in schizophrenia may affect their function, i.e. membrane transport, impairment of energy production in mitochondria, changes in membrane phospholipid composition, alteration of receptors and transporters as well as neurotransmission. The purpose of the present study was to assess the total antioxidant capacity (TAC) and lipid peroxidation (expressed as the level of thiobarbituric acid reactive substances [TBARS]) in plasma from schizophrenic patients taking olanzapine or risperidone. The level of TBARS estimated according to the Rice-Evans method and TAC ([ABTS; 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) radical cation decolorization assay]) in plasma from schizophrenic patients (DSM-IV criteria for schizophrenia, n = 30, age 18-36) taking olanzapine or risperidone and from healthy volunteers (n = 30) were measured. METHODS: The level of TBARS in plasma from healthy volunteers after incubation with olanzapine or risperidone was also estimated. RESULTS: Significantly lower plasma TAC (P < 0.05) and significantly increased level of TBARS (P < 0.001) in schizophrenic patients were observed. The in vitro study showed that after olanzapine or risperidone (at final concentrations corresponding to doses used in acute episodes of schizophrenia treatment) no changes of plasma lipid peroxidation were found (P > 0.05). The obtained results indicate that the pro-oxidant disturbances occur in schizophrenic patients (acute episode) taking stable doses of olanzapine or risperidone. CONCLUSION: It seems that second-generation antipsychotics (olanzapine and risperidone) are not responsible for increase of plasma lipid peroxidation. SN - 1440-1819 UR - https://www.unboundmedicine.com/medline/citation/20923426/full_citation L2 - https://doi.org/10.1111/j.1440-1819.2010.02132.x DB - PRIME DP - Unbound Medicine ER -