Tags

Type your tag names separated by a space and hit enter

Prospective study of pandysmaturation and adult mental disorder in high-risk and normal-risk offspring.
J Psychiatr Res. 2011 Apr; 45(4):561-7.JP

Abstract

More than 50 years ago, Fish postulated that a special form of early abnormal neurodevelopment, "pandysmaturation", defined a priori as constituting retarded cranial development in the first year of life, combined with delay in early motor milestone attainment, was related to genetic risk for schizophrenia, and was associated with schizophrenia-spectrum disorders in young adulthood. Fish confirmed this in a very small sample. We retested Fish's postulation in a larger prospective study. Pandysmaturation was blindly investigated through medical records and prospective researcher and maternal observations, studying 75 "high-risk" offspring of women with a history of schizophrenia or affective psychosis and 91 "normal-risk" offspring. Subjects were studied prospectively from mother's pregnancy to 22 years of age, at which time the offspring were independently assessed for schizophrenia-spectrum and affective disorders. Pandysmaturation (n = 13, with 10 "definite" and 3 "probable" degrees) was significantly related to genetic risk for schizophrenia (Odds Ratio 4.9, p = 0.02) but not to genetic risk for affective disorders (OR 1.2, p = 0.81). Pandysmaturation was significantly associated with schizophrenia-spectrum (OR 6.2, p = 0.02), but not affective (OR 0.9, p = 0.90), disorders in young adulthood. Pandysmaturation was more strongly associated than was retarded cranial development, motor milestone delay, or social/cognitive milestone delay by itself. Pandysmaturation has efficacy as an early life risk-indicator of schizophrenia-spectrum disorder in young adulthood at least in subjects at genetic risk, strengthening the evidence for a generally genetic-based neurodevelopmental model of schizophrenia-spectrum (as contrasted with affective) disorders. Pandysmaturation is a risk-indicator for future schizophrenia-spectrum disorder, for potential use in scientific studies and clinical practice.

Authors+Show Affiliations

Department of Psychiatric Epidemiology, University Hospital in Lund, Barngatan 2, 221 85 Lund, Sweden. thomas.mcneil@med.lu.seNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20926100

Citation

McNeil, Thomas F., et al. "Prospective Study of Pandysmaturation and Adult Mental Disorder in High-risk and Normal-risk Offspring." Journal of Psychiatric Research, vol. 45, no. 4, 2011, pp. 561-7.
McNeil TF, Fish B, Schubert EW. Prospective study of pandysmaturation and adult mental disorder in high-risk and normal-risk offspring. J Psychiatr Res. 2011;45(4):561-7.
McNeil, T. F., Fish, B., & Schubert, E. W. (2011). Prospective study of pandysmaturation and adult mental disorder in high-risk and normal-risk offspring. Journal of Psychiatric Research, 45(4), 561-7. https://doi.org/10.1016/j.jpsychires.2010.09.010
McNeil TF, Fish B, Schubert EW. Prospective Study of Pandysmaturation and Adult Mental Disorder in High-risk and Normal-risk Offspring. J Psychiatr Res. 2011;45(4):561-7. PubMed PMID: 20926100.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prospective study of pandysmaturation and adult mental disorder in high-risk and normal-risk offspring. AU - McNeil,Thomas F, AU - Fish,Barbara, AU - Schubert,Erland W, PY - 2010/05/21/received PY - 2010/09/14/revised PY - 2010/09/14/accepted PY - 2010/10/8/entrez PY - 2010/10/12/pubmed PY - 2011/7/14/medline SP - 561 EP - 7 JF - Journal of psychiatric research JO - J Psychiatr Res VL - 45 IS - 4 N2 - More than 50 years ago, Fish postulated that a special form of early abnormal neurodevelopment, "pandysmaturation", defined a priori as constituting retarded cranial development in the first year of life, combined with delay in early motor milestone attainment, was related to genetic risk for schizophrenia, and was associated with schizophrenia-spectrum disorders in young adulthood. Fish confirmed this in a very small sample. We retested Fish's postulation in a larger prospective study. Pandysmaturation was blindly investigated through medical records and prospective researcher and maternal observations, studying 75 "high-risk" offspring of women with a history of schizophrenia or affective psychosis and 91 "normal-risk" offspring. Subjects were studied prospectively from mother's pregnancy to 22 years of age, at which time the offspring were independently assessed for schizophrenia-spectrum and affective disorders. Pandysmaturation (n = 13, with 10 "definite" and 3 "probable" degrees) was significantly related to genetic risk for schizophrenia (Odds Ratio 4.9, p = 0.02) but not to genetic risk for affective disorders (OR 1.2, p = 0.81). Pandysmaturation was significantly associated with schizophrenia-spectrum (OR 6.2, p = 0.02), but not affective (OR 0.9, p = 0.90), disorders in young adulthood. Pandysmaturation was more strongly associated than was retarded cranial development, motor milestone delay, or social/cognitive milestone delay by itself. Pandysmaturation has efficacy as an early life risk-indicator of schizophrenia-spectrum disorder in young adulthood at least in subjects at genetic risk, strengthening the evidence for a generally genetic-based neurodevelopmental model of schizophrenia-spectrum (as contrasted with affective) disorders. Pandysmaturation is a risk-indicator for future schizophrenia-spectrum disorder, for potential use in scientific studies and clinical practice. SN - 1879-1379 UR - https://www.unboundmedicine.com/medline/citation/20926100/Prospective_study_of_pandysmaturation_and_adult_mental_disorder_in_high_risk_and_normal_risk_offspring_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3956(10)00277-3 DB - PRIME DP - Unbound Medicine ER -