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Reactivity of cortical alpha rhythms to eye opening in mild cognitive impairment and Alzheimer's disease: an EEG study.
J Alzheimers Dis. 2010; 22(4):1047-64.JA

Abstract

Cortical sources of resting eyes-closed alpha rhythms are typically abnormal in mild cognitive impairment (MCI) and Alzheimer's disease (AD) subjects. Here we tested the hypothesis of a progressive impairment of cortical alpha reactivity to eye-opening across amnesic MCI and mild AD subjects, reflecting another aspect of the impairment of cortical neural synchronization. Resting electroencephalography (EEG) data were recorded in 36 normal elderly subjects (Nold), 91 amnesic MCI, and 31 mild AD subjects during eyes-closed and -open conditions. EEG sources were estimated by LORETA software. In the eye-closed condition, posterior alpha 1 (8-10.5 Hz) sources were lower in MCI and AD than Nold subjects. The opposite was true for occipital delta sources (2-4 Hz). Reactivity to the eyes-open condition showed posterior alpha 1 and alpha 2 (10.5-13 Hz) sources was high in the Nold, intermediate in the MCI, and low in the AD subjects. Furthermore, occipital alpha 1 reactivity across MCI and AD subjects was correlated to the cognitive impairment as revealed by Mini-Mental State Examination score. In conclusion, at least at group level, the continuum across amnesic MCI and mild AD status is related to an impaired reactivity of cortical neuronal synchronization to eyes opening at alpha rhythms.

Authors+Show Affiliations

Department of Biomedical Sciences, University of Foggia, Foggia, Italy. c.babiloni@unifg.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20930306

Citation

Babiloni, Claudio, et al. "Reactivity of Cortical Alpha Rhythms to Eye Opening in Mild Cognitive Impairment and Alzheimer's Disease: an EEG Study." Journal of Alzheimer's Disease : JAD, vol. 22, no. 4, 2010, pp. 1047-64.
Babiloni C, Lizio R, Vecchio F, et al. Reactivity of cortical alpha rhythms to eye opening in mild cognitive impairment and Alzheimer's disease: an EEG study. J Alzheimers Dis. 2010;22(4):1047-64.
Babiloni, C., Lizio, R., Vecchio, F., Frisoni, G. B., Pievani, M., Geroldi, C., Claudia, F., Ferri, R., Lanuzza, B., & Rossini, P. M. (2010). Reactivity of cortical alpha rhythms to eye opening in mild cognitive impairment and Alzheimer's disease: an EEG study. Journal of Alzheimer's Disease : JAD, 22(4), 1047-64. https://doi.org/10.3233/JAD-2010-100798
Babiloni C, et al. Reactivity of Cortical Alpha Rhythms to Eye Opening in Mild Cognitive Impairment and Alzheimer's Disease: an EEG Study. J Alzheimers Dis. 2010;22(4):1047-64. PubMed PMID: 20930306.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reactivity of cortical alpha rhythms to eye opening in mild cognitive impairment and Alzheimer's disease: an EEG study. AU - Babiloni,Claudio, AU - Lizio,Roberta, AU - Vecchio,Fabrizio, AU - Frisoni,Giovanni B, AU - Pievani,Michela, AU - Geroldi,Cristina, AU - Claudia,Fracassi, AU - Ferri,Raffaele, AU - Lanuzza,Bartolo, AU - Rossini,Paolo M, PY - 2010/10/9/entrez PY - 2010/10/12/pubmed PY - 2011/5/26/medline SP - 1047 EP - 64 JF - Journal of Alzheimer's disease : JAD JO - J Alzheimers Dis VL - 22 IS - 4 N2 - Cortical sources of resting eyes-closed alpha rhythms are typically abnormal in mild cognitive impairment (MCI) and Alzheimer's disease (AD) subjects. Here we tested the hypothesis of a progressive impairment of cortical alpha reactivity to eye-opening across amnesic MCI and mild AD subjects, reflecting another aspect of the impairment of cortical neural synchronization. Resting electroencephalography (EEG) data were recorded in 36 normal elderly subjects (Nold), 91 amnesic MCI, and 31 mild AD subjects during eyes-closed and -open conditions. EEG sources were estimated by LORETA software. In the eye-closed condition, posterior alpha 1 (8-10.5 Hz) sources were lower in MCI and AD than Nold subjects. The opposite was true for occipital delta sources (2-4 Hz). Reactivity to the eyes-open condition showed posterior alpha 1 and alpha 2 (10.5-13 Hz) sources was high in the Nold, intermediate in the MCI, and low in the AD subjects. Furthermore, occipital alpha 1 reactivity across MCI and AD subjects was correlated to the cognitive impairment as revealed by Mini-Mental State Examination score. In conclusion, at least at group level, the continuum across amnesic MCI and mild AD status is related to an impaired reactivity of cortical neuronal synchronization to eyes opening at alpha rhythms. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/20930306/Reactivity_of_cortical_alpha_rhythms_to_eye_opening_in_mild_cognitive_impairment_and_Alzheimer's_disease:_an_EEG_study_ DB - PRIME DP - Unbound Medicine ER -