Studies in catalytic C-H amination involving nitrene C-H insertion.Dalton Trans. 2010 Nov 21; 39(43):10401-13.DT
Stereoselective catalytic intermolecular C-H amination of complex molecules is reported. Site-selective functionalizations occur with very good yields up to 91% and excellent d.e.s up to 99%. However, the precise nature of the nitrene C-H insertion remains a matter of debate despite several physical organic experiments.