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Transgenic animal models of neurodegeneration based on human genetic studies.
J Neural Transm (Vienna). 2011 Jan; 118(1):27-45.JN

Abstract

The identification of genes linked to neurodegenerative diseases such as Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), Huntington's disease (HD) and Parkinson's disease (PD) has led to the development of animal models for studying mechanism and evaluating potential therapies. None of the transgenic models developed based on disease-associated genes have been able to fully recapitulate the behavioral and pathological features of the corresponding disease. However, there has been enormous progress made in identifying potential therapeutic targets and understanding some of the common mechanisms of neurodegeneration. In this review, we will discuss transgenic animal models for AD, ALS, HD and PD that are based on human genetic studies. All of the diseases discussed have active or complete clinical trials for experimental treatments that benefited from transgenic models of the disease.

Authors+Show Affiliations

Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA. bharvey@intra.nida.nih.govNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Intramural
Review

Language

eng

PubMed ID

20931247

Citation

Harvey, Brandon K., et al. "Transgenic Animal Models of Neurodegeneration Based On Human Genetic Studies." Journal of Neural Transmission (Vienna, Austria : 1996), vol. 118, no. 1, 2011, pp. 27-45.
Harvey BK, Richie CT, Hoffer BJ, et al. Transgenic animal models of neurodegeneration based on human genetic studies. J Neural Transm (Vienna). 2011;118(1):27-45.
Harvey, B. K., Richie, C. T., Hoffer, B. J., & Airavaara, M. (2011). Transgenic animal models of neurodegeneration based on human genetic studies. Journal of Neural Transmission (Vienna, Austria : 1996), 118(1), 27-45. https://doi.org/10.1007/s00702-010-0476-6
Harvey BK, et al. Transgenic Animal Models of Neurodegeneration Based On Human Genetic Studies. J Neural Transm (Vienna). 2011;118(1):27-45. PubMed PMID: 20931247.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Transgenic animal models of neurodegeneration based on human genetic studies. AU - Harvey,Brandon K, AU - Richie,Christopher T, AU - Hoffer,Barry J, AU - Airavaara,Mikko, Y1 - 2010/10/08/ PY - 2010/08/10/received PY - 2010/08/23/accepted PY - 2010/10/9/entrez PY - 2010/10/12/pubmed PY - 2011/4/26/medline SP - 27 EP - 45 JF - Journal of neural transmission (Vienna, Austria : 1996) JO - J Neural Transm (Vienna) VL - 118 IS - 1 N2 - The identification of genes linked to neurodegenerative diseases such as Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), Huntington's disease (HD) and Parkinson's disease (PD) has led to the development of animal models for studying mechanism and evaluating potential therapies. None of the transgenic models developed based on disease-associated genes have been able to fully recapitulate the behavioral and pathological features of the corresponding disease. However, there has been enormous progress made in identifying potential therapeutic targets and understanding some of the common mechanisms of neurodegeneration. In this review, we will discuss transgenic animal models for AD, ALS, HD and PD that are based on human genetic studies. All of the diseases discussed have active or complete clinical trials for experimental treatments that benefited from transgenic models of the disease. SN - 1435-1463 UR - https://www.unboundmedicine.com/medline/citation/20931247/Transgenic_animal_models_of_neurodegeneration_based_on_human_genetic_studies_ L2 - https://doi.org/10.1007/s00702-010-0476-6 DB - PRIME DP - Unbound Medicine ER -