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Production of human metabolites of the anti-cancer drug flutamide via biotransformation in Cunninghamella species.
Biotechnol Lett. 2011 Feb; 33(2):321-6.BL

Abstract

Fungi belonging to the genus Cunninghamella have enzymes similar to those employed by mammals for the detoxification of xenobiotics, thus they are useful as models of mammalian drug metabolism, and as a source for drug metabolites. We report the transformation of the anti-cancer drug flutamide in Cunninghamella sp. The most predominant phase I metabolites present in the plasma of humans, 2-hydroxyflutamide and 4-nitro-3-(trifluoromethyl)aniline, were also produced in Cunninghamella cultures. Other phase I and phase II metabolites were also detected using a combination of HPLC, GC-MS and (19)F-NMR.

Authors+Show Affiliations

School of Biomolecular and Biomedical Science, Centre for Synthesis and Chemical Biology, University College Dublin, Ardmore House, Dublin 4, Ireland.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20931353

Citation

Amadio, Jessica, and Cormac D. Murphy. "Production of Human Metabolites of the Anti-cancer Drug Flutamide Via Biotransformation in Cunninghamella Species." Biotechnology Letters, vol. 33, no. 2, 2011, pp. 321-6.
Amadio J, Murphy CD. Production of human metabolites of the anti-cancer drug flutamide via biotransformation in Cunninghamella species. Biotechnol Lett. 2011;33(2):321-6.
Amadio, J., & Murphy, C. D. (2011). Production of human metabolites of the anti-cancer drug flutamide via biotransformation in Cunninghamella species. Biotechnology Letters, 33(2), 321-6. https://doi.org/10.1007/s10529-010-0425-3
Amadio J, Murphy CD. Production of Human Metabolites of the Anti-cancer Drug Flutamide Via Biotransformation in Cunninghamella Species. Biotechnol Lett. 2011;33(2):321-6. PubMed PMID: 20931353.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Production of human metabolites of the anti-cancer drug flutamide via biotransformation in Cunninghamella species. AU - Amadio,Jessica, AU - Murphy,Cormac D, Y1 - 2010/10/08/ PY - 2010/08/24/received PY - 2010/09/23/accepted PY - 2010/10/9/entrez PY - 2010/10/12/pubmed PY - 2011/4/16/medline SP - 321 EP - 6 JF - Biotechnology letters JO - Biotechnol. Lett. VL - 33 IS - 2 N2 - Fungi belonging to the genus Cunninghamella have enzymes similar to those employed by mammals for the detoxification of xenobiotics, thus they are useful as models of mammalian drug metabolism, and as a source for drug metabolites. We report the transformation of the anti-cancer drug flutamide in Cunninghamella sp. The most predominant phase I metabolites present in the plasma of humans, 2-hydroxyflutamide and 4-nitro-3-(trifluoromethyl)aniline, were also produced in Cunninghamella cultures. Other phase I and phase II metabolites were also detected using a combination of HPLC, GC-MS and (19)F-NMR. SN - 1573-6776 UR - https://www.unboundmedicine.com/medline/citation/20931353/Production_of_human_metabolites_of_the_anti_cancer_drug_flutamide_via_biotransformation_in_Cunninghamella_species_ L2 - https://doi.org/10.1007/s10529-010-0425-3 DB - PRIME DP - Unbound Medicine ER -