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Seroprevalence of autoimmune thyroiditis and celiac disease in children with insulin-dependent diabetes mellitus in the Thrace region of Turkey.
Turk J Gastroenterol 2010; 21(3):231-5TJ

Abstract

BACKGROUND/AIMS

We aimed to estimate the seroprevalence of celiac disease, a gluten-sensitive enteropathy, and autoimmune thyroiditis in children with insulin-dependent diabetes mellitus in the Thrace region of Turkey.

METHODS

The population studied consisted of 33 children with insulin-dependent diabetes mellitus and 41 healthy children with demographic features similar to the study subjects. Free triiodothyronine, free thyroxine, thyroid-stimulating hormone, anti-thyroid peroxidase antibody, anti-thyroglobulin antibody, IgA, anti-endomysium IgA, and anti-gliadin IgA were measured in all cases and controls.

RESULTS

The serum levels of free triiodothyronine and free thyroxine were within the normal range in all cases. However, in one patient who had anti-thyroid peroxidase and antithyroglobulin antibodies, the thyroid-stimulating hormone level was high despite a normal free triiodothyronine and free thyroxine value. Ultrasonographic findings confirmed thyroiditis in this patient. Anti-thyroid peroxidase antibodies, anti-thyroglobulin antibodies, anti-endomysium IgA and anti-gliadin IgA were detected in 15.4%, 6%, 9.1% and 3% of the diabetic cases, respectively. None of these antibodies was detected in the control group. In the diabetic group, the seroprevalences of the antithyroid peroxidase antibodies and the anti-endomysium IgA were statistically higher than in the control group (p<0.05).

CONCLUSIONS

Children with insulin-dependent diabetes mellitus in our region should undergo periodic screenings for autoimmune thyroiditis and celiac disease.

Authors+Show Affiliations

Department of Pediatrics, İstanbul University, Cerrahpaşa School of Medicine, İstanbul. soyucen2007@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20931425

Citation

Soyucen, Erdoğan, et al. "Seroprevalence of Autoimmune Thyroiditis and Celiac Disease in Children With Insulin-dependent Diabetes Mellitus in the Thrace Region of Turkey." The Turkish Journal of Gastroenterology : the Official Journal of Turkish Society of Gastroenterology, vol. 21, no. 3, 2010, pp. 231-5.
Soyucen E, Yilmaz S, Çeltık C, et al. Seroprevalence of autoimmune thyroiditis and celiac disease in children with insulin-dependent diabetes mellitus in the Thrace region of Turkey. Turk J Gastroenterol. 2010;21(3):231-5.
Soyucen, E., Yilmaz, S., Çeltık, C., Vatansever, U., Öner, N., & Karasalıhoğlu, S. (2010). Seroprevalence of autoimmune thyroiditis and celiac disease in children with insulin-dependent diabetes mellitus in the Thrace region of Turkey. The Turkish Journal of Gastroenterology : the Official Journal of Turkish Society of Gastroenterology, 21(3), pp. 231-5.
Soyucen E, et al. Seroprevalence of Autoimmune Thyroiditis and Celiac Disease in Children With Insulin-dependent Diabetes Mellitus in the Thrace Region of Turkey. Turk J Gastroenterol. 2010;21(3):231-5. PubMed PMID: 20931425.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Seroprevalence of autoimmune thyroiditis and celiac disease in children with insulin-dependent diabetes mellitus in the Thrace region of Turkey. AU - Soyucen,Erdoğan, AU - Yilmaz,Sema, AU - Çeltık,Coşkun, AU - Vatansever,Ulfet, AU - Öner,Naci, AU - Karasalıhoğlu,Serap, PY - 2010/10/9/entrez PY - 2010/10/12/pubmed PY - 2011/2/1/medline SP - 231 EP - 5 JF - The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology JO - Turk J Gastroenterol VL - 21 IS - 3 N2 - BACKGROUND/AIMS: We aimed to estimate the seroprevalence of celiac disease, a gluten-sensitive enteropathy, and autoimmune thyroiditis in children with insulin-dependent diabetes mellitus in the Thrace region of Turkey. METHODS: The population studied consisted of 33 children with insulin-dependent diabetes mellitus and 41 healthy children with demographic features similar to the study subjects. Free triiodothyronine, free thyroxine, thyroid-stimulating hormone, anti-thyroid peroxidase antibody, anti-thyroglobulin antibody, IgA, anti-endomysium IgA, and anti-gliadin IgA were measured in all cases and controls. RESULTS: The serum levels of free triiodothyronine and free thyroxine were within the normal range in all cases. However, in one patient who had anti-thyroid peroxidase and antithyroglobulin antibodies, the thyroid-stimulating hormone level was high despite a normal free triiodothyronine and free thyroxine value. Ultrasonographic findings confirmed thyroiditis in this patient. Anti-thyroid peroxidase antibodies, anti-thyroglobulin antibodies, anti-endomysium IgA and anti-gliadin IgA were detected in 15.4%, 6%, 9.1% and 3% of the diabetic cases, respectively. None of these antibodies was detected in the control group. In the diabetic group, the seroprevalences of the antithyroid peroxidase antibodies and the anti-endomysium IgA were statistically higher than in the control group (p<0.05). CONCLUSIONS: Children with insulin-dependent diabetes mellitus in our region should undergo periodic screenings for autoimmune thyroiditis and celiac disease. SN - 2148-5607 UR - https://www.unboundmedicine.com/medline/citation/20931425/Seroprevalence_of_autoimmune_thyroiditis_and_celiac_disease_in_children_with_insulin_dependent_diabetes_mellitus_in_the_Thrace_region_of_Turkey_ L2 - http://www.turkjgastroenterol.org/eng/makale/3214/219/Full-Text DB - PRIME DP - Unbound Medicine ER -