Tags

Type your tag names separated by a space and hit enter

Cutaneous disorders in uremic patients on hemodialysis: an Egyptian case-controlled study.
Int J Dermatol 2010; 49(9):1024-30IJ

Abstract

BACKGROUND

We studied the prevalence of mucocutaneous disorders in uremic adults and children on hemodialysis (HD) vs. controls, in Egypt.

METHODS

A total of 206 Egyptians with uremia (163 adults and 43 children) undergoing HD, and 199 healthy controls (161 adults and 38 children), were examined for mucocutaneous abnormalities.

RESULTS

Specific cutaneous diseases associated with renal insufficiency were found in five adults, including acquired perforating dermatosis and pseudo-porphyria. Non-specific abnormalities included xerosis (54%), pallor (42.2%), nail changes (34.9%), hair changes (34%), pruritus (32%), hyper-pigmentation (22.2%), coated tongue (14.1%), ecchymosis (1.5%), and gingival hypertrophy (1.5%). Disorders found significantly more often in uremics than controls included pallor, nail changes, hair changes, pruritus, hyperpigmentation and coated tongue in adults (P < 0.05), and nail changes, hair changes, and hyper-pigmentation in children (P < 0.05). The prevalence of each mucocutaneous abnormality was similar in uremic adults and children except for pallor [more common in adults (P = 0.001)], and hyper-pigmentation [more common in children (P = 0.003)]. A greater number of hepatitis C virus-positive than -negative adult uremics had hyper-pigmentation (P < 0.05), and more diabetic uremics had pruritus than did non-diabetics (P < 0.05).

CONCLUSION

Mucocutaneous disorders occur in adults and children with uremia, some of which are specific associations with the underlying renal disease. Occurrence of some of the non-specific abnormalities, such as xerosis, ecchymosis, and gingival hypertrophy, may be coincidental or associated with factors other than renal insufficiency.

Authors+Show Affiliations

Department of Dermatology, Venereology, and Andrology, Faculty of Medicine, Ain Shams University, Cairo, Egypt. annosah74@hotmail.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20931673

Citation

Attia, Enas A S., et al. "Cutaneous Disorders in Uremic Patients On Hemodialysis: an Egyptian Case-controlled Study." International Journal of Dermatology, vol. 49, no. 9, 2010, pp. 1024-30.
Attia EA, Hassan SI, Youssef NM. Cutaneous disorders in uremic patients on hemodialysis: an Egyptian case-controlled study. Int J Dermatol. 2010;49(9):1024-30.
Attia, E. A., Hassan, S. I., & Youssef, N. M. (2010). Cutaneous disorders in uremic patients on hemodialysis: an Egyptian case-controlled study. International Journal of Dermatology, 49(9), pp. 1024-30.
Attia EA, Hassan SI, Youssef NM. Cutaneous Disorders in Uremic Patients On Hemodialysis: an Egyptian Case-controlled Study. Int J Dermatol. 2010;49(9):1024-30. PubMed PMID: 20931673.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cutaneous disorders in uremic patients on hemodialysis: an Egyptian case-controlled study. AU - Attia,Enas A S, AU - Hassan,Samah I, AU - Youssef,Nagwa M, PY - 2010/10/9/entrez PY - 2010/10/12/pubmed PY - 2011/2/2/medline SP - 1024 EP - 30 JF - International journal of dermatology JO - Int. J. Dermatol. VL - 49 IS - 9 N2 - BACKGROUND: We studied the prevalence of mucocutaneous disorders in uremic adults and children on hemodialysis (HD) vs. controls, in Egypt. METHODS: A total of 206 Egyptians with uremia (163 adults and 43 children) undergoing HD, and 199 healthy controls (161 adults and 38 children), were examined for mucocutaneous abnormalities. RESULTS: Specific cutaneous diseases associated with renal insufficiency were found in five adults, including acquired perforating dermatosis and pseudo-porphyria. Non-specific abnormalities included xerosis (54%), pallor (42.2%), nail changes (34.9%), hair changes (34%), pruritus (32%), hyper-pigmentation (22.2%), coated tongue (14.1%), ecchymosis (1.5%), and gingival hypertrophy (1.5%). Disorders found significantly more often in uremics than controls included pallor, nail changes, hair changes, pruritus, hyperpigmentation and coated tongue in adults (P < 0.05), and nail changes, hair changes, and hyper-pigmentation in children (P < 0.05). The prevalence of each mucocutaneous abnormality was similar in uremic adults and children except for pallor [more common in adults (P = 0.001)], and hyper-pigmentation [more common in children (P = 0.003)]. A greater number of hepatitis C virus-positive than -negative adult uremics had hyper-pigmentation (P < 0.05), and more diabetic uremics had pruritus than did non-diabetics (P < 0.05). CONCLUSION: Mucocutaneous disorders occur in adults and children with uremia, some of which are specific associations with the underlying renal disease. Occurrence of some of the non-specific abnormalities, such as xerosis, ecchymosis, and gingival hypertrophy, may be coincidental or associated with factors other than renal insufficiency. SN - 1365-4632 UR - https://www.unboundmedicine.com/medline/citation/20931673/Cutaneous_disorders_in_uremic_patients_on_hemodialysis:_an_Egyptian_case_controlled_study_ L2 - https://doi.org/10.1111/j.1365-4632.2010.04466.x DB - PRIME DP - Unbound Medicine ER -