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In vitro and in vivo antioxidant properties of chlorogenic acid and caffeic acid.
Int J Pharm. 2011 Jan 17; 403(1-2):136-8.IJ

Abstract

Dietary polyphenols are thought to be beneficial for human health as antioxidants. Coffee beans contain a common polyphenol, chlorogenic acid. Chlorogenic acid is the ester of caffeic acid and quinic acid. Although these polyphenols have received much attention, there is little evidence indicating a relationship between the effect and the rate of absorption. In this study, we focused on the beneficial effects of chlorogenic acid and caffeic acid, a major metabolite of chlorogenic acid. We carried out in vitro and in vivo experiments. In the in vitro study, caffeic acid had stronger antioxidant activity than that of chlorogenic acid. The uptake of chlorogenic acid by Caco-2 cells was much less than that of caffeic acid. The physiological importance of an orally administered compound depends on its availability for intestinal absorption and subsequent interaction with target tissues. We then used an intestinal ischemia-reperfusion model to evaluate antioxidant activities in vivo. We found that both chlorogenic acid and caffeic acid had effects on intestinal ischemia-reperfusion injury. Since caffeic acid has a stronger antioxidant activity than that of chlorogenic acid and chlorogenic acid is hydrolyzed into caffeic acid in the intestine, it is possible that caffeic acid plays a major role in the protective effect of chlorogenic acid against ischemia-reperfusion injury.

Authors+Show Affiliations

Hokkaido University, Kita-12-jo, Nishi-6-chome, Kita-ku, Sapporo 060-0812, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20933071

Citation

Sato, Yuki, et al. "In Vitro and in Vivo Antioxidant Properties of Chlorogenic Acid and Caffeic Acid." International Journal of Pharmaceutics, vol. 403, no. 1-2, 2011, pp. 136-8.
Sato Y, Itagaki S, Kurokawa T, et al. In vitro and in vivo antioxidant properties of chlorogenic acid and caffeic acid. Int J Pharm. 2011;403(1-2):136-8.
Sato, Y., Itagaki, S., Kurokawa, T., Ogura, J., Kobayashi, M., Hirano, T., Sugawara, M., & Iseki, K. (2011). In vitro and in vivo antioxidant properties of chlorogenic acid and caffeic acid. International Journal of Pharmaceutics, 403(1-2), 136-8. https://doi.org/10.1016/j.ijpharm.2010.09.035
Sato Y, et al. In Vitro and in Vivo Antioxidant Properties of Chlorogenic Acid and Caffeic Acid. Int J Pharm. 2011 Jan 17;403(1-2):136-8. PubMed PMID: 20933071.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro and in vivo antioxidant properties of chlorogenic acid and caffeic acid. AU - Sato,Yuki, AU - Itagaki,Shirou, AU - Kurokawa,Toshimitsu, AU - Ogura,Jiro, AU - Kobayashi,Masaki, AU - Hirano,Takeshi, AU - Sugawara,Mitsuru, AU - Iseki,Ken, Y1 - 2010/10/07/ PY - 2010/07/06/received PY - 2010/09/22/revised PY - 2010/09/28/accepted PY - 2010/10/12/entrez PY - 2010/10/12/pubmed PY - 2011/3/22/medline SP - 136 EP - 8 JF - International journal of pharmaceutics JO - Int J Pharm VL - 403 IS - 1-2 N2 - Dietary polyphenols are thought to be beneficial for human health as antioxidants. Coffee beans contain a common polyphenol, chlorogenic acid. Chlorogenic acid is the ester of caffeic acid and quinic acid. Although these polyphenols have received much attention, there is little evidence indicating a relationship between the effect and the rate of absorption. In this study, we focused on the beneficial effects of chlorogenic acid and caffeic acid, a major metabolite of chlorogenic acid. We carried out in vitro and in vivo experiments. In the in vitro study, caffeic acid had stronger antioxidant activity than that of chlorogenic acid. The uptake of chlorogenic acid by Caco-2 cells was much less than that of caffeic acid. The physiological importance of an orally administered compound depends on its availability for intestinal absorption and subsequent interaction with target tissues. We then used an intestinal ischemia-reperfusion model to evaluate antioxidant activities in vivo. We found that both chlorogenic acid and caffeic acid had effects on intestinal ischemia-reperfusion injury. Since caffeic acid has a stronger antioxidant activity than that of chlorogenic acid and chlorogenic acid is hydrolyzed into caffeic acid in the intestine, it is possible that caffeic acid plays a major role in the protective effect of chlorogenic acid against ischemia-reperfusion injury. SN - 1873-3476 UR - https://www.unboundmedicine.com/medline/citation/20933071/In_vitro_and_in_vivo_antioxidant_properties_of_chlorogenic_acid_and_caffeic_acid_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(10)00755-6 DB - PRIME DP - Unbound Medicine ER -