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Synthesis and in vitro antimicrobial evaluation of novel fluoroquinolone derivatives.
Eur J Med Chem. 2010 Dec; 45(12):6101-5.EJ

Abstract

A series of 1-ethyl-6,8-difluoro-4-oxo-7(4-aryl piperazin-1-yl) 1,4-dihydro-quinoline-3-carboxylic acid derivatives (6a-f) and 1-ethyl-6,8-difluoro-4-oxo-7(4-piperidin-1-yl) 1,4-dihydro-quinoline-3-carboxylic acid derivatives (7a-e) were synthesized and evaluated for antibacterial and antifungal activities. The antimicrobial activities of the compounds were assessed by the microbroth dilution technique. The compounds were also evaluated for antifungal activity against Candida albicans (ATCC 90028) and Cryptococcous neoformans (ATCC 14116) pathogens. The preliminary in vitro evaluation studies revealed that some of the compounds have promising antimicrobial activities.

Authors+Show Affiliations

Department of Industrial Chemistry, Alagappa University, Karaikudi-630 003, Tamil Nadu, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20933306

Citation

Srinivasan, Shanmugam, et al. "Synthesis and in Vitro Antimicrobial Evaluation of Novel Fluoroquinolone Derivatives." European Journal of Medicinal Chemistry, vol. 45, no. 12, 2010, pp. 6101-5.
Srinivasan S, Beema Shafreen RM, Nithyanand P, et al. Synthesis and in vitro antimicrobial evaluation of novel fluoroquinolone derivatives. Eur J Med Chem. 2010;45(12):6101-5.
Srinivasan, S., Beema Shafreen, R. M., Nithyanand, P., Manisankar, P., & Pandian, S. K. (2010). Synthesis and in vitro antimicrobial evaluation of novel fluoroquinolone derivatives. European Journal of Medicinal Chemistry, 45(12), 6101-5. https://doi.org/10.1016/j.ejmech.2010.09.036
Srinivasan S, et al. Synthesis and in Vitro Antimicrobial Evaluation of Novel Fluoroquinolone Derivatives. Eur J Med Chem. 2010;45(12):6101-5. PubMed PMID: 20933306.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synthesis and in vitro antimicrobial evaluation of novel fluoroquinolone derivatives. AU - Srinivasan,Shanmugam, AU - Beema Shafreen,Raja Mohmed, AU - Nithyanand,Paramasivam, AU - Manisankar,Paramasivam, AU - Pandian,Shunmugiah Karutha, Y1 - 2010/09/22/ PY - 2010/01/19/received PY - 2010/09/15/revised PY - 2010/09/16/accepted PY - 2010/10/12/entrez PY - 2010/10/12/pubmed PY - 2011/3/8/medline SP - 6101 EP - 5 JF - European journal of medicinal chemistry JO - Eur J Med Chem VL - 45 IS - 12 N2 - A series of 1-ethyl-6,8-difluoro-4-oxo-7(4-aryl piperazin-1-yl) 1,4-dihydro-quinoline-3-carboxylic acid derivatives (6a-f) and 1-ethyl-6,8-difluoro-4-oxo-7(4-piperidin-1-yl) 1,4-dihydro-quinoline-3-carboxylic acid derivatives (7a-e) were synthesized and evaluated for antibacterial and antifungal activities. The antimicrobial activities of the compounds were assessed by the microbroth dilution technique. The compounds were also evaluated for antifungal activity against Candida albicans (ATCC 90028) and Cryptococcous neoformans (ATCC 14116) pathogens. The preliminary in vitro evaluation studies revealed that some of the compounds have promising antimicrobial activities. SN - 1768-3254 UR - https://www.unboundmedicine.com/medline/citation/20933306/Synthesis_and_in_vitro_antimicrobial_evaluation_of_novel_fluoroquinolone_derivatives_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0223-5234(10)00684-7 DB - PRIME DP - Unbound Medicine ER -