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Macronutrient advice for ischemic heart disease prevention.
Curr Opin Lipidol 2011; 22(1):33-6CO

Abstract

PURPOSE OF REVIEW

Intake of saturated fatty acids (SFAs) increases the low-density lipoprotein cholesterol concentration in plasma and has therefore been suggested to increase the risk of ischemic heart disease (IHD). Focus on limiting SFA intake without specifying the substitutions may be counterproductive because SFAs may be replaced with other equally or more harmful macronutrients. Recent findings on substitution of specified macronutrients for SFAs and risk of IHD are reviewed.

RECENT FINDINGS

Recent cohort studies suggest that intake of polyunsaturated fatty acids (PUFAs) or carbohydrates with low-glycemic index values in place of SFAs is associated with a lower risk of IHD whereas intake of carbohydrates with high-glycemic index values in place of SFAs is associated with a higher risk of IHD.

SUMMARY

Cohort studies and randomized clinical trials provide convincing evidence of a lower risk of IHD associated with substitution of PUFAs for SFAs. Analyzing substitution of specified macronutrients for SFAs offers a perspective different from the single nutrient focus and may provide further insight into IHD prevention.

Authors+Show Affiliations

Department of Epidemiology, School of Public Health, Aarhus University, Aarhus, Denmark. muj@soci.au.dkNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

20935565

Citation

Jakobsen, Marianne U., and Kim Overvad. "Macronutrient Advice for Ischemic Heart Disease Prevention." Current Opinion in Lipidology, vol. 22, no. 1, 2011, pp. 33-6.
Jakobsen MU, Overvad K. Macronutrient advice for ischemic heart disease prevention. Curr Opin Lipidol. 2011;22(1):33-6.
Jakobsen, M. U., & Overvad, K. (2011). Macronutrient advice for ischemic heart disease prevention. Current Opinion in Lipidology, 22(1), pp. 33-6. doi:10.1097/MOL.0b013e32834020a3.
Jakobsen MU, Overvad K. Macronutrient Advice for Ischemic Heart Disease Prevention. Curr Opin Lipidol. 2011;22(1):33-6. PubMed PMID: 20935565.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Macronutrient advice for ischemic heart disease prevention. AU - Jakobsen,Marianne U, AU - Overvad,Kim, PY - 2010/10/12/entrez PY - 2010/10/12/pubmed PY - 2011/4/19/medline SP - 33 EP - 6 JF - Current opinion in lipidology JO - Curr. Opin. Lipidol. VL - 22 IS - 1 N2 - PURPOSE OF REVIEW: Intake of saturated fatty acids (SFAs) increases the low-density lipoprotein cholesterol concentration in plasma and has therefore been suggested to increase the risk of ischemic heart disease (IHD). Focus on limiting SFA intake without specifying the substitutions may be counterproductive because SFAs may be replaced with other equally or more harmful macronutrients. Recent findings on substitution of specified macronutrients for SFAs and risk of IHD are reviewed. RECENT FINDINGS: Recent cohort studies suggest that intake of polyunsaturated fatty acids (PUFAs) or carbohydrates with low-glycemic index values in place of SFAs is associated with a lower risk of IHD whereas intake of carbohydrates with high-glycemic index values in place of SFAs is associated with a higher risk of IHD. SUMMARY: Cohort studies and randomized clinical trials provide convincing evidence of a lower risk of IHD associated with substitution of PUFAs for SFAs. Analyzing substitution of specified macronutrients for SFAs offers a perspective different from the single nutrient focus and may provide further insight into IHD prevention. SN - 1473-6535 UR - https://www.unboundmedicine.com/medline/citation/20935565/Macronutrient_advice_for_ischemic_heart_disease_prevention_ L2 - http://dx.doi.org/10.1097/MOL.0b013e32834020a3 DB - PRIME DP - Unbound Medicine ER -