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Prevention of mutation, cancer, and other age-associated diseases by optimizing micronutrient intake.
J Nucleic Acids. 2010 Sep 22; 2010JN

Abstract

I review three of our research efforts which suggest that optimizing micronutrient intake will in turn optimize metabolism, resulting in decreased DNA damage and less cancer as well as other degenerative diseases of aging. (1) Research on delay of the mitochondrial decay of aging, including release of mutagenic oxidants, by supplementing rats with lipoic acid and acetyl carnitine. (2) The triage theory, which posits that modest micronutrient deficiencies (common in much of the population) accelerate molecular aging, including DNA damage, mitochondrial decay, and supportive evidence for the theory, including an in-depth analysis of vitamin K that suggests the importance of achieving optimal micronutrient intake for longevity. (3) The finding that decreased enzyme binding constants (increased Km) for coenzymes (or substrates) can result from protein deformation and loss of function due to an age-related decline in membrane fluidity, or to polymorphisms or mutation. The loss of enzyme function can be compensated by a high dietary intake of any of the B vitamins, which increases the level of the vitamin-derived coenzyme. This dietary remediation illustrates the importance of understanding the effects of age and polymorphisms on optimal micronutrient requirements. Optimizing micronutrient intake could have a major effect on the prevention of cancer and other degenerative diseases of aging.

Authors+Show Affiliations

Nutrition and Metabolism Center, Children's Hospital Oakland Research Institute, 5700 Martin Luther King Jr. Way, Oakland, CA 94609, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20936173

Citation

Ames, Bruce N.. "Prevention of Mutation, Cancer, and Other Age-associated Diseases By Optimizing Micronutrient Intake." Journal of Nucleic Acids, vol. 2010, 2010.
Ames BN. Prevention of mutation, cancer, and other age-associated diseases by optimizing micronutrient intake. J Nucleic Acids. 2010;2010.
Ames, B. N. (2010). Prevention of mutation, cancer, and other age-associated diseases by optimizing micronutrient intake. Journal of Nucleic Acids, 2010. https://doi.org/10.4061/2010/725071
Ames BN. Prevention of Mutation, Cancer, and Other Age-associated Diseases By Optimizing Micronutrient Intake. J Nucleic Acids. 2010 Sep 22;2010 PubMed PMID: 20936173.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevention of mutation, cancer, and other age-associated diseases by optimizing micronutrient intake. A1 - Ames,Bruce N, Y1 - 2010/09/22/ PY - 2010/06/08/received PY - 2010/07/30/accepted PY - 2010/10/12/entrez PY - 2010/10/12/pubmed PY - 2010/10/12/medline JF - Journal of nucleic acids JO - J Nucleic Acids VL - 2010 N2 - I review three of our research efforts which suggest that optimizing micronutrient intake will in turn optimize metabolism, resulting in decreased DNA damage and less cancer as well as other degenerative diseases of aging. (1) Research on delay of the mitochondrial decay of aging, including release of mutagenic oxidants, by supplementing rats with lipoic acid and acetyl carnitine. (2) The triage theory, which posits that modest micronutrient deficiencies (common in much of the population) accelerate molecular aging, including DNA damage, mitochondrial decay, and supportive evidence for the theory, including an in-depth analysis of vitamin K that suggests the importance of achieving optimal micronutrient intake for longevity. (3) The finding that decreased enzyme binding constants (increased Km) for coenzymes (or substrates) can result from protein deformation and loss of function due to an age-related decline in membrane fluidity, or to polymorphisms or mutation. The loss of enzyme function can be compensated by a high dietary intake of any of the B vitamins, which increases the level of the vitamin-derived coenzyme. This dietary remediation illustrates the importance of understanding the effects of age and polymorphisms on optimal micronutrient requirements. Optimizing micronutrient intake could have a major effect on the prevention of cancer and other degenerative diseases of aging. SN - 2090-021X UR - https://www.unboundmedicine.com/medline/citation/20936173/Prevention_of_mutation_cancer_and_other_age_associated_diseases_by_optimizing_micronutrient_intake_ L2 - https://doi.org/10.4061/2010/725071 DB - PRIME DP - Unbound Medicine ER -
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